発表論文・著書

1.     Ogawa, T., Kiryu-Seo, S., Tanaka, M., Konishi, H., Iwata, N., Saido, T., Watanabe, Y., and Kiyama, H.: Altered expression of neprilysin family members in pituitary gland of sleep-disturbed rat, an animal model of severe fatigue. J. Neurochem., 95: 1156-1166, 2005.

2.     Hino, K., Nishikawa, M., Sato, E., and Inoue, M.: l-Carnitine inhibits hypoglycemia-induced brain damage in the rat. Brain Res., 1053:77-87, 2005.

3.     Tanaka, M., Sadato, M,.Okada, T., Mizuno, K., Sasabe, T., Tanabe, H.C., Saito, D.N., Onoe, H., Kuratsune, H., and Watanabe, Y.: Reduced responsiveness is an essential feature of chronic fatigue syndrome: A fMRI study. BMC Neurology, 6: 9, 2006.

4.     Sakudo, A., Kuratsune, H., Kobayashi, T., Tajima, S., Watanabe, Y., and Ikuta, K.: Spectroscopic diagnosis of chronic fatigue syndrome by visible and near-infrared spectroscopy in serum samples. Biophys. Biochem. Res. Commun., 345:1513-1516, 2006.

5.     Kirisako, T., Kamei, K., Murata, S., Kato, M., Fukumoto, H., Kanie, K., Sano, S. Tokunaga, F., Tanaka, K. and Iwai, K.: A ubiquitin ligase complex assembles linear polyubiquitin chains. EMBO J., 25(20): 4877–4887, 2006.

6.     Tahara, T., Tanaka, M., Nozaki, S., Jin, G., Onoe, H., and Watanabe, Y.: Decrease of hepatic delta-aminolevulinate dehydratase activity in an animal model of fatigue. Biochem. Biophys. Res. Commun., 353: 1068-1073, 2007.

7.     Mizuno, K., Tanaka, M., Nozaki, S., Yamaguti, K., Mizuma, H., Sasabe, T., Sugino, T., Shirai, T., Kataoka, Y., Kajimoto, Y., Kuratsune, H., Kajimoto, O., and Watanabe, Y.: Mental fatigue-induced decrease in levels of several plasma amino acids. J. Neural Transm., 114: 555-561, 2007.

8.     Ataka, S., Tanaka, M., Nozaki, S., Mizuma, H., Mizuno, K., Tahara, T., Sugino, T., Shirai, T., Kajimoto, Y., Kuratsune, H., Kajimoto, O., and Watanabe, Y.: Effects of Applephenon((R)) and ascorbic acid on physical fatigue. Nutrition, 23:419-423, 2007.

9.     Yamamoto, S., Onoe, H., Tsukada, H., and Watanabe, Y.: Effects of increased endogenous serotonin on the in vivo binding of [(11)C]DASB to serotonin transporters in conscious monkey brain. Synapse, 61: 724-731, 2007.

10. Nojima, J., Sakudo, A., Hakariya, Y., Kuratsune, H., Watanabe, Y., Kanakura, Y., and Ikuta, K.: Spectroscopic diagnosis of anti-phospholipid antibodies by visible and near-infrared spectroscopy in SLE patients' plasma samples. Biochem. Biophys. Res. Commun., 362(2): 522-4, 2007.

11. Ueta, R., Fujiwara, N., Iwai, K. (corresponding author) and Yamaguchi-Iwai, Y.: Mechanism underlying the iron-dependent nuclear export of the iron-responsive transcription factor Aft1p in Saccharomyces cerevisiae. Mol. Biol. Cell , 18(8):2980-2990, 2007.

12. Sakata, E., Yamaguchi, Y., Miyauchi, Y., Iwai, K., Chiba, T., Saeki, Y., Matsuda, N., Tanaka, K. and Kato, K.: Direct interactions between Nedd8 and ubiquitin E2 conjugating enzymes contribute to up-regulation of cullin-based E3 ligase activity. Nature Struct. Mol. Biol., 14(2):167-168, 2007.

13. Nojima, J., Masuda, Y., Iwatani, Y., Suehisa, E., Futsukaichi, Y. Kuratsune, H., Watanabe, Y., Takano, T., Hidaka, Y., and Kanakura, Y.: Tissue factor expression on monocytes induced by anti-phospholipid antibodies as a strong risk factor for thromboembolic complications in SLE patients. Biochem. Biophys. Res. Commun., 365(1): 195-200, 2008.

14. Mizuno, K., Tanaka, M., Nozaki, S., Mizuma, H., Ataka, S., Tahara, T., Sugino, T., Shirai, T., Kajimoto, Y., Kuratsune, H., Kajimoto, O., and Watanabe, Y.: Antifatigue effects of coenzyme Q10 during physical fatigue. Nutrition, 24(4): 293-299, 2008.

15. Ataka, S., Tanaka, M., Nozaki, S., Mizuma, H., Mizuno, K., Tahara, T., Sugino, T., Shirai, T., Kajimoto, Y., Kuratsune, H., Kajimoto, O., and Watanabe, Y.: Effects of oral administration of caffeine and D-ribose on mental fatigue. Nutrition, 24(3): 233-238, 2008.

16. Tanaka, M., and Watanabe, Y.: Reduced energy utilization in the brain is a feature of an animal model of fatigue. Int. J. Neurosci., 118(5): 683-692, 2008.

17. Tanaka, M., Baba, Y., Kataoka, Y., Kinbara, N., Sagesakac, Y., Kakuda, T., Watanabe, Y.: Effects of (-)-epigallocatechin gallate in liver of an animal model of combined (physical and mental) fatigue. Nutrition, 24(6): 599-603, 2008.

18. Mizuno, K., Tanaka, M., Ishii, A., Tanabe, H.C, Onoe, H.,Sadato, N., and Watanabe, Y.: The neural basis of academic achievement motivation. NeuroImage, 42: 369-378, 2008.

19. Yoshida, M., Tanaka, M., Mizuno, K., Ishii, A., Nozaki, K., Urakawa, A., Cho, Y., Kataoka, Y., and Watanabe, Y.: Factors influencing the academic motivation of individual college students. Int. J. Neurosci., 118(10): 1400-1411, 2008.

20.     Tanaka, M., Mizuno, K., Fukuda, S., Shigihara, Y., and Watanabe, Y.: Relationships between dietary habits and the prevalence of fatigue in medical students. Nutrition, 24(10): 985-989, 2008.

21.     Hiramoto, K., Homma, T., Jikumaru, M., Miyashita, H., Sato, E.F., and Inoue, M.: Fasting Differentially Modulates the Immunological System: Its Mechanism and Sex Difference. J. Clin. Biochem. Nut., 43: 75-81, 2008.

22.     Kitamura, K., Nakayama, K., Kosaka, S., Yamada, E., Shimada, H., Miki, T., and Inoue, Y.:　Diffusion tensor imaging of the cortico-ponto-cerebellar pathway in patients with adult-onset ataxic neurodegenerative disease.　Neuroradiology.　50(4): 285-292, 2008.

23.     Tamiya, H., Kobayashi, H., Yamanaka, K., Fujita, N., Tsuruta, D., Mizuno, N., and Ishii, M.:　Immobilization stress suppresses cutaneous delayed-type hypersensitivity reaction induced by gastrointestinal sensitization in mice: association with Langerhans cell of the forestomach.　Stress and Health, 24(2): 109-114, 2008.

24.     Kobayashi, H., Ishii, M., Takeuchi, S., Tanaka, Y., Shintani, T., Yamatodani, A., Kusunoki T., and Furue, M.: Efficacy and Safety of a Traditional Herbal Medicine, Hochu-ekki-to in the Long-term Management of Kikyo (Delicate Constitution) Patients with Atopic Dermatitis: A 6-month, Multicenter, Double-blind, Randomized, Placebo-controlled Study. Evid. Based Complement. Altemat. Med., 2008 [Epub ahead of print].

25.     Oe, H., Hozumi, T., Murata, E., Matsuura, H., Negishi, K., Matsumura, Y., Iwata, S., Ogawa, K., Sugioka, K., Takemoto, Y., Shimada, K., Yoshiyama, M., Ishikura, Y., Kiso, Y., Yoshikawa, J.: Arachidonic acid and docosahexaenoic acid supplementation increases coronary flow velocity reserve in Japanese elderly individuals. Heart. 94(3):316-21, 2008.

26.     Nozaki, S., Tanaka, M., Mizuno, K., Ataka, S., Mizuma, H., Tahara, T., Sugino, T., Shirai, T., Eguchi, A, Okuyama, K., Yoshida, K., kajimoto, Y., Kuratsune, H., kajimoto, O., and Watanabe, Y.: Mental and physical fatigue-related biochemical alterations. Nutrition, 25(1):51-7, 2009.

27.     Tanaka, M., Mizuno, K., Fukuda, S., Shigihara, Y., Tajima, S., and Watanabe, Y.: Personality traits associated with intrinsic academic motivation in medical students. Med. Educ., 43(4):384-387, 2009.

28.     Tanaka, M., Fukuda, S., Mizuno, K., Imai-Matsumura, K., Jodoi, T., Kawatani, J., Takano, M., Tomoda, A., Miike, T., and Watanabe, Y.: Reliability and validity of the Japanese version of the Chalder Fatigue Scale among youth in Japan. Psychol. Rep., 103(3): 683-690, 2009.

29. Tanaka, M., Mizuno, K. and Watanabe, Y.: Central nervous system fatigue alters autonomic nerve activity. Life Sci., 13;84(7-8):235-9, 2009.

30. Jin, GH., Kataoka, Y., Tanaka, M., Mizuma, H., Nozaki, S., Tahara, T., Mizuno, K., Yamato, M., and Watanabe, Y.: Changes in plasma and tissue amino acid levels in an animal model of complex fatigue. Nutrition, 25(5): 597-607, 2009.

31. Ogawa, T., Shishioh-Ikejima, N., Konishi, H., Makino, T., Sei, H., Kiryu-Seo, S., Tanaka, M., Watanabe, Y., and Kiyama, H.: Chronic stress elicits prolonged activation of α-MSH secretion and subsequent degeneration of melanotroph. J. Neurochem., 109: 1389–1399, 2009.

32. Fukuda, T., Sumi, T., Nobeyama, H., Yoshida, H., Matsumoto, Y., Yasui, T., Honda, K., Ishiko, O.: Multiple organ failure of tumor-bearing rabbits in cancer cachexia is caused by apoptosis of normal organ cells. Int. J. Oncol., 34: 61-67, 2009.

33. Kasahara, E., Kashiba, M., Jikumaru, M., Kurtsune, D., Orita, K., Yamate, Y., Hara, K., Sekiyama, A., Sato, E.F. and Inoue, M.: Dynamic aspects of ascorbic acid metabolism in the circulation: analysis by ascorbate oxidase with a prolonged in vivo half-life. Biochem. J., 2009[Epub ahead of print].

34. Nojima, J., Masuda, Y., Iwatani, Y., Kuratsune, H., Watanabe, Y., Suehisa, E., Takano, T., Hidaka, Y., and Kanakura, Y.: Arteriosclerosis Obliterans Associated with IgG Anti-cardiolipin/β2-glycoprotein I Antibodies as a Strong Risk Factor for Ischemic Heart Disease in Patients with Systemic Lupus Erythematosus. Rheumatology, in press, 2009.

35. Tanaka, M., Fukuda, S., Mizuno, K., Yoshida, K., Kuratsune, H. and Watanabe, Y.: Stress and coping style are associated with severe fatigue in medical students. Behav. Med., in press, 2009.

36. Tajima, K., Tanaka, M., Mizuno, K., Okuyama, K., Yoshida, K., Okada, N., Rokushima, K. and Watanabe, Y.: Effects of bathing in micro-bubbles on recovery from fatigue. Ergonomia, in press, 2009.

37. Fukuda, S., Kuratsune H., Tajima, S., Takashima, S., Yamaguti, K., Nishizawa, Y., Watanabe,Y. : Premorbid personality in chconic fatigue syndrome as detemined by the Temperament and Character Inventory. Compr. Psychiatry, in press, 2009.

38. Matsuda, Y., Matsui, T., Kataoka, K., Fukada, R., Fukuda, S., Kuratsune, H., Tajima, S., Yamaguti, K., Hakariya-Kato, Y., and Kiriike, N.: A Two-Year Follow-up Study of Chronic Fatigue Syndrome Comorbid with Psychiatric Disorders. Psychiatry Clin. Neurosci., in press, 2009.

【原著論文以外による発表】

1.     渡辺恭良（企画）:医学のあゆみ、第1土曜特集「最新・疲労の科学－日本発：抗疲労・抗過労への提言」、医歯薬出版株式会社、第228巻、第6号、2009年2月7日

2.     Watanbe, Y., Evengård, B., Natelson, B., Jason, L.D., Kuratsune, H., eds.: Fatigue Science for Human Health,Springer, 2008, Springer Japan.

3.  西沢良記：腎不全における代謝異常と良質な長寿－透析患者の慢性疲労研究を踏まえて－、最新透析医学（西沢良記編）、28-36(総734頁)、医薬ジャーナル社、2008年7月

4. 渡辺恭良、病態医学から健康科学へ－疲労と癒しの科学－、最新透析医学（西沢良記編）、18-22(総734頁)、医薬ジャーナル社、2008年7月．

5.    田島世貴、倉恒弘彦、山口浩二、高橋あゆみ、高島昇子、渡辺恭良、西沢良記：慢性疲労症候群　基礎・臨床研究の最新動向、慢性疲労症候群の診断、検査法の進歩　慢性疲労症候群のマーカー　アクティグラフ、アクティブトレーサーを用いた方法、日本臨床、65(6):1057-1064、2007．

6. 田島世貴、西沢良記：疲労・倦怠、慢性疲労をしばしばきたす病態の鑑別診断と治療法、生活習慣病、綜合臨床、 55(1): 81-85、2006．
　