主要論文

 

  1. Umeda T., Ramser E.M., Yamashita M., Nakajima K., Mori H., Silverman M.A., Tomiyama T.* Intracellular amyloid β oligomers impair organelle transport and induce dendritic spine loss in primary neurons. Acta Neuropathol. Commun., 3, 51, 2015.

  2. Honjo Y., Ayaki T., Tomiyama T., Horibe T., Ito H., Mori H., Takahashi R., Kawakami K.* Increased GADD34 in oligodendrocytes in Alzheimer's disease. Neurosci. Lett., 602, 50-55, 2015.

  3. Umeda T., Eguchi H., Kunori Y., Matsumoto Y., Taniguchi T., Mori H., Tomiyama T.* Passive immunotherapy of tauopathy targeting pSer413-tau: a pilot study in mice. Ann. Clin. Transl. Neurol., 2, 241-255, 2015.

  4. Umeda T., Maekawa S., Kimura T., Takashima A., Tomiyama T.*, Mori H. Neurofibrillary tangle formation by introducing wild-type human tau into APP transgenic mice. Acta Neuropathol., 127, 685-698, 2014.

  5. Nomura S., Umeda T., Tomiyama T.*, Mori H. The E693Δ (Osaka) mutation in amyloid precursor protein potentiates cholesterol-mediated intracellular amyloid b toxicity via its impaired cholesterol efflux. J. Neurosci. Res., 91, 1541-1550, 2013.

  6. Umeda T., Yamashita T., Kimura T., Ohnishi K., Takuma H., Ozeki T., Takashima A., Tomiyama T., Mori H.* Neurodegenerative disorder FTDP-17 related tau intron 10 +16C→T mutation increases tau exon 10 splicing and causes tauopathy in transgenic mice. Am. J. Pathol., 183, 211-225, 2013.

  7. Takano M., Yamashita T., Nagano K., Otani M., Maekura K., Kamada H., Tsunoda S., Tsutsumi Y., Tomiyama T., Mori H., Matsuura K., Matsuyama S.* Proteomic analysis of the hippocampus in Alzheimer's disease model mice by using two-dimensional fluorescence difference in gel electrophoresis. Neurosci. Lett., 534, 85-89, 2013.

  8. Takano M., Maekura K., Otani M., Sano K., Nakamura-Hirota T., Tokuyama S., Min K.S., Tomiyama T., Mori H., Matsuyama S.* Proteomic analysis of the brain tissues from a transgenic mouse model of amyloid b oligomers. Neurochem. Int., 61, 347-355, 2012.

  9. Umeda T., Tomiyama T.*, Kitajima E., Idomoto T., Nomura S., Lambert M.P., Klein W.L., Mori H. Hypercholesterolemia accelerates intraneuronal accumulation of Ab oligomers resulting in memory impairment in Alzheimer’s disease model mice. Life Sci., 91, 1169-1176, 2012.

  10. Shimada H.*, Ataka S., Tomiyama T., Takechi H., Mori H., Miki T. Clinical course of patients with a familial early-onset Alzheimer’s disease potentially lacking senile plaques bearing the E693D mutation in amyloid precursor protein. Dement. Geriatr. Cogn. Disord., 32, 45-54, 2011.

  11. Umeda T., Tomiyama T.*, Sakama N., Tanaka S., Lambert M.P., Klein W.L., Mori H. Intraneuronal amyloid b oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo. J. Neurosci. Res., 89, 1031-1042, 2011.

  12. Maeda J., Zhang M.-R., Okauchi T., Ji B., Ono M., Hattori S., Kumata K., Iwata N., Saido T. C., Trojanowski J. Q., Lee V. M.-Y., Staufenbiel M., Tomiyama T., Mori H., Fukumura T., Suhara T. Higuchi M.* In vivo positron emission tomographic imaging of glial responses to amyloid-b and tau pathologies in mouse models of Alzheimer's disease and related disorders. J. Neurosci., 31, 4720-4730, 2011.

  13. Suzuki T., Murakami K., Izuo N., Kume T., Akaike A., Nagata T., Nishizaki T., Tomiyama T., Takuma H., Mori H., Irie K.* E22D mutation in amyloid b-protein promotes b-sheet transformation, radical production, and synaptotoxicity, but not neurotoxicity. Int. J. Alzheimers Dis., 2011, Article ID 431320, 2011.

  14. Tomiyama T.*, Matsuyama S., Iso H., Umeda T., Takuma H., Ohnishi K., Ishibashi K., Teraoka R., Sakama N., Yamashita T., Nishitsuji K., Ito K., Shimada H., Lambert M.P., Klein W.L., Mori H. A mouse model of amyloid b oligomers: Their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo. J. Neurosci., 30, 4845-4856, 2010.

  15. Umeda T., Mori H., Zheng H., Tomiyama T.* Regulation of cholesterol efflux by amyloid b secretion. J. Neurosci. Res., 88, 1985-1994, 2010.

  16. Nagata T., Tomiyama T., Mori H., Yaguchi T., Nishizaki T.* DCP-LA neutralizes mutant amyloid b peptide-induced impairment of long-term potentiation and spatial learning. Behav. Brain Res., 206, 151-154, 2010.

  17. Suga K.*, Saito A., Tomiyama T., Mori H., Akagawa K. The syntaxin 5 isoforms Syx5 and Syx5L have distinct effects on the processing of b-amyloid precursor protein. J. Biochem., 146, 905-915, 2009.

  18. Ito K., Ishibashi K., Tomiyama T., Umeda T., Yamamoto K., Kitajima E., Idomoto T., Nagatomo T., Mori H.* Oligomeric amyloid b-protein as a therapeutic target in Alzheimer's disease: its significance based on its distinct localization and the occurrence of a familial variant form. Curr. Alzheimer Res., 6, 132-136, 2009..

  19. Nishitsuji K., Tomiyama T.*, Ishibashi K., Ito K., Teraoka R., Lambert M.P., Klein W.L., Mori H. The E693D mutation in amyloid precursor protein increases intracellular accumulation of amyloid b oligomers and causes endoplasmic reticulum stress-induced apoptosis in cultured cells. Am. J. Pathol., 174, 957-969, 2009.

  20. Takuma H., Teraoka R., Mori H., Tomiyama T.*Amyloid b E22D variant induces synaptic alteration in mouse hippocampal slices. Neuroreport 19, 615-619, 2008.

  21. Tomiyama T., Nagata T., Shimada H., Teraoka R., Fukushima A., Kanemitsu H., Takuma H., Kuwano R., Imagawa M., Ataka S., Wada Y., Yoshioka E., Nishizaki T., Watanabe Y., Mori H.* A new amyloid b variant favoring oligomerization in Alzheimer's-type dementia. Ann. Neurol. 63, 377-387, 2008.

  22. Maeda J., Ji B., Irie T., Tomiyama T., Maruyama M., Okauchi T., Staufenbiel M., Iwata N., Ono M., Saido T.C., Suzuki K., Mori H., Higuchi M.*, Suhara T. Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography. J. Neurosci. 27, 10957-10968, 2007.

  23. Ono M.*, Hori H., Haratake M., Tomiyama T., Mori H., Nakayama M. Structure-activity relationship of chalcones and rekated derivatives as ligands for detecting of b-amyloid plaques in the brain. Bioorg. Med. Chem. 15, 6388-6396, 2007.

  24. Nishitsuji K., Tomiyama T., Ishibashi K., Kametani F., Ozawa K., Okada R., Maat-Schieman M.L., Roos R.A.C., Iwai K., Mori H.* Cerebral vascular accumulation of Dutch-type Ab42, but not wild-type Ab42, in hereditary cerebral hemorrhage with amyloidosis, Dutch type. J. Neurosci. Res. 85, 2917-2923, 2007.

  25. Matsuyama S., Teraoka R., Mori H., Tomiyama T.* Inverse correlation between amyloid precursor protein and synaptic plasticity in transgenic mice. Neuroreport 18, 1083-1087, 2007.

  26. Sennvik K., Boekhoorn K., Lasrado R., Terwel D., Verhaeghe S., Korr H., Schmitz C., Tomiyama T., Mori H., Krugers H., Joels M., Ramakers G.J.A., Lucassen P.J., van Leuven F.* Tau-4R suppresses proliferation and promotes neuronal differentiation in the hippocampus of tau knockin/knockout mice. FASEB J. 21, 2149-2161, 2007.

  27. Ishibashi K., Tomiyama T., Nishitsuji K., Hara M., Mori H.* Absence of synaptophysin near cortical neurons containing oligomer Ab in Alzheimer's disease brain. J. Neurosci. Res. 84, 632-636, 2006.

  28. Boekhoorn K., Terwel D., Biemans B., Borghgraef P., Wiegert O., Ramakers G.J., de Vos K., Krugers H., Tomiyama T., Mori H., Joels M., van Leuven F.*, Lucassen P.J. Improved long-term potentiation and memory in young tau-P301L transgenic mice before onset of hyperphosphorylation and tauopathy. J. Neurosci. 26, 3514-3523, 2006.

  29. Suga K.*, Saito A., Tomiyama T., Mori H., Akagawa K. Syntaxin 5 interacts specifically with presenilin holoproteins and affects processing of bAPP in neuronal cells. J. Neurochem. 94, 425-439, 2005.

  30. Yamashita T., Tomiyama T., Li Q., Numata H., Mori H.* Regulation of tau exon 10 splicing by a double stem-loop structure in mouse intron 10. FEBS Lett. 579, 241-244, 2005.

  31. Kosaka S., Takuma H., Tomiyama T., Mori H.* The distributions of tau short and long isoforms fused with EGFP in cultured cells. Osaka City Med. J. 50, 19-27, 2004.

  32. Ataka S., Tomiyama T., Takuma H., Yamashita T., Shimada H., Tsutada T., Kawabata K., Mori H.*, Miki T. A novel presenilin-1 mutation (Leu85Pro) in early-onset Alzheimer disease with spastic paraparesis. JAMA Neurol. (formerly Arch. Neurol.) 61, 1773-1776, 2004.

  33. Suga K.*, Tomiyama T., Mori H., Akagawa K. Syntaxin 5 interacts with presenilin holoproteins, but not with their N- or C-terminal fragments, and affects b-amyloid peptide production. Biochem. J. 381, 619-628, 2004.

  34. Takuma H., Tomiyama T., Kuida K., Mori H.* Amyloid b peptide-induced cerebral neuronal loss is mediated by caspase-3 in vivo. J. Neuropathol. Exp. Neurol. 63, 255-261, 2004.

  35. Kanemitsu H., Tomiyama T., Mori H.* Human neprilysin is capable of degrading amyloid b peptide not only in the monomeric form but also the pathological oligomeric form. Neurosci. Lett. 350, 113-116, 2003.

  36. Hashimoto Y., Tomiyama T., Yamano Y., Mori H.* Mutation (D472Y) in the type 3 repeat domain of cartilage oligomeric matrix protein affects its early vesicle trafficking in endoplasmic reticulum and induces apoptosis. Am. J. Pathol. 163, 101-110, 2003.

  37. Mori H.*, Tomiyama T., Maeda N., Ozawa K., Wakasa K. Lack of amyloid plaque formation in the central nervous system of a patient with Werner syndrome. Neuropathology 23, 51-56, 2003.

  38. Hebert S.S., Godin C., Tomiyama T., Mori H., Levesque G.* Dimerization of presenilin-1 in vivo: suggestion of novel
    regulatory mechanisms leading to higher order complexes. Biochem. Biophys. Res. Commun. 301, 119-126, 2003.

  39. Ozawa K., Tomiyama T., Maat-Schieman M.L., Roos R.A., Mori H.* Enhanced Ab40 deposition was associated with increased Ab42/43 in cerebral vasculature with Dutch-type hereditary cerebral hemorrhage with amyloidosis (HCHWA-D). Ann. N. Y. Acad. Sci. 977, 149-154, 2002.

  40. Ishii K., Lippa C., Tomiyama T., Miyatake F., Ozawa K., Tamaoka A., Hasegawa T., Fraser P.E., Shoji S., Nee N.E., Pollen D.A., St George-Hyslop P.H., Ii K., Ohtake T., Kalaria R.N., Rossor M.N., Lantos P.L., Cairns N.J., Farrer LA., Mori H.* Distinguishable effects of presenilin-1 and APP717 mutations on amyloid plaque deposition. Neurobiol. Aging 22, 367-376, 2001.

  41. Sahara N., Tomiyama T., Mori H.* Missense point mutations of tau to segregate with FTDP-17 exhibit site-specific effects on microtubule structure in COS cells: A novel action of R406W mutation. J. Neurosci. Res. 60, 380-387, 2000.

  42. Tomiyama T., Corder E.H., Mori H.* Molecular pathogenesis of apolipoprotein E-associated late-onset Alzheimer's disease. Cell. Mol. Life Sci. 56, 268-279, 1999.