Publications

-Japan2012

-2012

Ogawa T, Enomoto M, Fujii H, Sekiya Y, Yoshizato K, Ikeda K, Kawada N.
MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis.
Gut. 2012 Jan 20. [Epub ahead of print]

Matsubara T, Li F, Gonzalez FJ.
FXR signaling in the enterohepatic system.
Mol Cell Endocrinol 2012 IN PRESS

Matsunaga T, Maruyama S, Matsubara T, Nagata K, Yamazoe Y, Ohmori S.
Mechanisms of CYP3A Induction by glucocorticoids in human fetal liver cells .
Drug Metab Pharmacokinet 2012 IN PRESS

Tanaka N, Matsubara T,  Krausz KW, Patterson AD, Gonzalez FJ.
Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis.
Hepatology 2012 IN PRESS

Patterson AD, Shah YM, Matsubara T, Krausz KW, Gonzalez FJ (2012)
PPAR dependent Induction of uncoupling protein 2 protects against acetaminophen-Induced liver toxicity
Hepatology 2012 IN PRESS"

Ozaki T, Matsubara T, Seo D, Okamoto M, Nagashima K, Sasaki Y, Hayase S, Murata T, Liao XH, Hanson J, Rodriguez-Canales J, Thorgeirsson SS, Kakudo K, Refetoff S, Kimura S.
Thyroid regeneration: characterization of clear cells after partial thyroidectomy.
Endocrinology .153(5):2514-2525 .2012

Pang XY, Cheng J, Kim JH, Matsubara T, Krausz KW, Gonzalez FJ.
Expression and regulation of human fetal-specific CYP3A7 in mice.
Endocrinology .153(3):1453-1463 .2012

Bonzo JA, Ferry CH, Matsubara T, Kim JH, Gonzalez FJ.
Suppression of hepatocyte proliferation by hepatocyte nuclear factor 4 in adult mice.
J Biol Chem.287(10):7345-7356.2012

Kisseleva T, Cong M, Paik Y, Scholten D, Jiang C, Benner C, Iwaisako K, Moore-Morris T, Scott B, Tsukamoto H, Evans SM, Dillmann W, Glass CK, Brenner DA.
Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis.
Proc Natl Acad Sci U S A. 2012 May 7.

Iwaisako K, Haimerl M, Paik YH, Taura K, Kodama Y, Sirlin C, Yu E, Yu RT, Downes M, Evans RM, Brenner DA, Schnabl B.
Protection from liver fibrosis by a peroxisome proliferator-activated receptor ƒÂ agonist.
Proc Natl Acad Sci U S A. 2012 Apr 25.

Iwaisako K, Brenner DA, Kisseleva T.
What's new in liver fibrosis? The origin of myofibroblasts in liver fibrosis. J Gastroenterol Hepatol.
2012 Mar;27 Suppl 2:65-8.

-2011

Sekiya Y, Ogawa T, Yoshizato K, Ikeda K, Kawada N.
Suppression of hepatic stellate cell activation by microRNA-29b.
Biochem Biophys Res Commun. 2011 Aug19;412(1):74-9.

Sekiya Y, Ogawa T, Iizuka M, Yoshizato K, Ikeda K, Kawada N.
Down-regulation of cyclin E1 expression by microRNA-195 accounts for interferon-beta-induced inhibition of hepatic stellate cell proliferation.
J Cell Physiol. 2011Oct;226(10):2535-42.

Thuy le TT, Morita T, Yoshida K, Wakasa K, Iizuka M, Ogawa T, Mori M, Sekiya Y, Momen S, Motoyama H, Ikeda K, Yoshizato K, Kawada N.
Promotion of liver and lung tumorigenesis in DEN-treated cytoglobin-deficient mice.
Am J Pathol. 2011 Aug;179(2):1050-60.

Miyaki T, Nojiri S, Shinkai N, Kusakabe A, Matsuura K, Iio E, Takahashi S, Yan G, Ikeda K, Joh T.
Pitavastatin inhibits hepatic steatosis and fibrosis in non-alcoholic steatohepatitis model rats. Hepatol Res.
2011 Apr;41(4):375-85.

Jiang C, Qu A, Matsubara T, Chanturiya T, Jou W, Gavrilova O, Shah YM, Gonzalez FJ.
Disruption of hypoxia-inducible factor 1 in adipocytesimproves insulin sensitivity and decreases adiposity in high-fat diet-fed mice.
Diabetes 60(10):2484-95 .2011

Qu A, Taylor M, Xue X, Matsubara T, Metzger D, Chambon P, Gonzalez FJ, Shah YM.
Hypoxia-inducible transcription factor 2ƒ¿ promotes steatohepatitis through augmenting lipid accumulation, inflammation and fibrosis.
Hepatology 54(2):472-483 .2011

Kurotani R, Okumura S, Matsubara T, Yokoyama U, Buckley JR, Tomita T, Kezuka K, Nagano T, Esposito D, Taylor TE, Gillette WK, Ishikawa Y, Abe H, Ward JM, Kimura S.
Secretoglobin 3A2 suppresses bleomycin-induced pulmonary fibrosis by TGFbeta signaling down-regulation.
J Biol Chem 286(22):19682-19692 .2011

Taylor M, Qu A, Anderson ER, Matsubara T, Martin A, Gonzalez FJ, Shah YM.
Hypoxia-inducible factor-2 is required for the adaptive increase of intestinal ferroportin during iron deficiency in mice.
Gastroenterology 140(7):2044-2055 .2011

Matsubara T, Tanaka N, Patterson AD, Cho JY, Krausz KW, Gonzalez FJ.
Lithocholic acid disrupts phospholipid and sphingolipid homeostasis leading to cholestasis in mice.
Hepatology 53(4):1282-1293 .2011

Yanagida A, Iwaisako K, Hatano E, Taura K, Sato F, Narita M, Nagata H, Asechi H, Uemoto S, Kinoshita M.
Downregulation of the Wnt antagonist Dkk2 links the loss of Sept4 and myofibroblastic transformation of hepatic stellate cells.
Biochim Biophys Acta. 2011 Nov;1812(11):1403-11. Epub 2011 Jul 6.

Brenner DA, Seki E, Taura K, Kisseleva T, Deminicis S, Iwaisako K, Inokuchi S, Schnabl B, Oesterreicher CH, Paik YH, Miura K, Kodama Y.
Non-alcoholic steatohepatitis-induced fibrosis: Toll-like receptors, reactive oxygen species and Jun N-terminal kinase.
Hepatol Res. 2011 Jul;41(7):683-6..

Paik YH, Iwaisako K, Seki E, Inokuchi S, Schnabl B, Osterreicher CH, Kisseleva T, Brenner DA.
The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice.
Hepatology. 2011 May;53(5):1730-41.

-2010

Imanishi H, Tsuruta D, Tateishi C, Sugawara K, Paus R, Tsuji T, Ishii M, Ikeda K, Kunimoto H, Nakajima K, Jones JC, Kobayashi H.
Laminin-511, inducer of hairgrowth, is down-regulated and its suppressor in hair growth, laminin-332 up-regulated in chemotherapy-induced alopecia.
J Dermatol Sci. 2010 Apr;58(1):43-54.

Ozawa T, Tsuruta D, Jones JC, Ishii M, Ikeda K, Harada T, Aoyama Y, Kawada A, Kobayashi H.
Dynamic relationship of focal contacts and hemidesmosome protein complexes in live cells.
J Invest Dermatol. 2010 Jun;130(6):1624-35.

Ogawa T, Iizuka M, Sekiya Y, Yoshizato K, Ikeda K, Kawada N.
Suppression of type I collagen production by microRNA-29b in cultured human stellate cells.
Biochem Biophys Res Commun. 2010 Jan 1;391(1):316-21.

Qu A, Shah YM, Matsubara T, Yang Q, Gonzalez FJ. (2010)
PPARalpha-dependent activation of cell cycle control and DNA repair genes in hepatic nonparenchymal cells.
Toxicol Sci 118(2):404-410.

Lee JH, Wada T, Febbraio M, He J, Matsubara T, Lee MJ, Gonzalez FJ, Xie W. (2010)
A novel role for the dioxin receptor in fatty acid metabolism and hepatic steatosis.
Gastroenterology 139(2):653-663.

Wang T, Shah YM, Matsubara T, Zhen Y, Tanabe T, Nagano T, Fotso S, Krausz KW, Zabriskie TM, Idle JR, Gonzalez FJ. (2010)
Control of steroid 21-oic acid synthesis by peroxisome prolferator-activated receptor alpha and the role of the hypothalamic-pituitary-adrenal axis.
J Biol Chem 285(10):7670-7685.

Cho JY, Matsubara T, Kang DW, Ahn SH, Krausz KW, Idle JR, Luecke H, Gonzalez FJ. (2010)
Urinary metabolomics in Fxr-null mice reveals activated adaptive metabolic pathways upon bile acid challenge.
J Lipid Res 51(5):1063-1074.

Scholten D, Osterreicher CH, Scholten A, Iwaisako K, Gu G, Brenner DA, Kisseleva T.
Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice.
Gastroenterology. 2010 Sep;139(3):987-98. Epub 2010 Jun 20.

Asechi H, Hatano E, Nitta T, Tada M, Iwaisako K, Tamaki N, Nagata H, Narita M, Yanagida A, Ikai I, Uemoto S.
Resistance to cisplatin-induced apoptosis via PI3K-dependent survivin expression in a rat hepatoma cell line.
Int J Oncol. 2010 Jul;37(1):89-96.

Taura K, Miura K, Iwaisako K, Osterreicher CH, Kodama Y, Penz-Osterreicher M, Brenner DA.
Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice.
Hepatology. 2010 Mar;51(3):1027-36.

-2009

Otogawa K, Ogawa T, Shiga R, Ikeda K, Kawada N.
Induction of tropomyosin during hepatic stellate cell activation and the progression of liver fibrosis.
Hepatol Int. 2009 Jun;3(2):378-83.

Ogawa T, Kawada N, Ikeda K.
Effect of natural interferon alpha on proliferation and apoptosis of hepatic stellate cells.
Hepatol Int. 2009 Apr 21 3:497-503.

Shinozaki M, Okada Y, Kitano A, Ikeda K, Saika S, Shinozaki M.
Impaired cutaneous wound healing with excess granulation tissue formation in TNFalpha-null mice.
Arch Dermatol Res. 2009 Aug;301(7):531-7.

Higashiyama R, Moro T, Nakao S, Mikami K, Fukumitsu H, Ueda Y, Ikeda K, Adachi E, Bou-Gharios G, Okazaki I, Inagaki Y.
Negligible contribution of bone marrow-derived cells to collagen production during hepatic fibrogenesis in mice.
Gastroenterology. 2009 Oct;137(4):1459-66.e1.

Saika S, Yamanaka O, Okada Y, Tanaka S, Miyamoto T, Sumioka T, Kitano A, Shirai K, Ikeda K.
TGF beta in fibroproliferative diseases in the eye.
Front Biosci (Schol Ed). 2009 Jun 1;1:376-90. Review.

Yamanaka O, Miyazaki K, Kitano A, Saika S, Nakajima Y, Ikeda K.
Suppression of injury-induced conjunctiva scarring by peroxisome proliferator-activated receptor gamma gene transfer in mice.
Invest Ophthalmol Vis Sci. 2009 Jan;50(1):187-93. 

Shah YM, Matsubara T, Ito S, Yim SH, Gonzalez FJ. (2009)
Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency.
Cell Metab 9(2):152-164.

Toriyabe T, Nagata K, Takada T, Aratsu Y, Matsubara T, Yoshinari K, Yamazoe Y. (2009)
Unveiling a new essential cis-element for the transactivation of the CYP3A4 gene by xenobiotics.
Mol Pharmacol 75(3):677-684.

Okoshi K, Saiga T, Hisamori S, Iwaisako K, Kobayashi H, Ogawa H.
A case of cytokeratin 20-positive large-cell neuroendocrine carcinoma of the breast.
Breast Cancer. 2009 Aug 11. [Epub ahead of print]

Kodama Y, Kisseleva T, Iwaisako K, Miura K, Taura K, De Minicis S, Osterreicher CH, Schnabl B, Seki E, Brenner DA.
c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice.
Gastroenterology. 2009 Oct;137(4):1467-1477.e5. Epub 2009 Jun 21.

Seo S, Hatano E, Higashi T, Nakajima A, Nakamoto Y, Tada M, Tamaki N, Iwaisako K, Kitamura K, Ikai I, Uemoto S.
P-glycoprotein expression affects 18F-fluorodeoxyglucose accumulation in hepatocellular carcinoma in vivo and in vitro.
Int J Oncol. 2009 May;34(5):1303-12.


																																

-2008

Sumioka T, Ikeda K, Okada Y, Yamanaka O, Kitano A, Saika S.
Inhibitory effect of blocking TGF-beta/Smad signal on injury-induced fibrosis of corneal endothelium.
Mol Vis. 2008;14:2272-81.

Kitano A, Yamanaka O, Ikeda K, Ishida-Nishikawa I, Okada Y, Shirai K, Saika S.
Tetrandrine suppresses activation of human subconjunctival fibroblasts in vitro.
Curr Eye Res. 2008 Jul;33(7):559-65.

Sakabe M, Sakata H, Matsui H, Ikeda K, Yamagishi T, Nakajima Y.
ROCK1 expression is regulated by TGFbeta3 and ALK2 during valvuloseptal endocardial cushion formation.
Anat Rec (Hoboken). 2008 Jul;291(7):845-57.

Saika S, Yamanaka O, Flanders KC, Okada Y, Miyamoto T, Sumioka T, Shirai K, Kitano A, Miyazaki K, Tanaka S, Ikeda K.
Epithelial-mesenchymal transition as a therapeutic target for prevention of ocular tissue fibrosis.
Endocr Metab Immune Disord Drug Targets. 2008 Mar;8(1):69-76. Review.

Miyazaki K, Okada Y, Yamanaka O, Kitano A, Ikeda K, Kon S, Uede T, Rittling SR, Denhardt DT, Kao WW, Saika S.
Corneal wound healing in an osteopontin-deficient mouse.
Invest Ophthalmol Vis Sci. 2008 Apr;49(4):1367-75.

Yamanaka O, Saika S, Ikeda K, Miyazaki K, Kitano A, Ohnishi Y.
Connective tissue growth factor modulates extracellular matrix production in human subconjunctival fibroblasts and their proliferation and migration in vitro.
Jpn J Ophthalmol. 2008 Jan-Feb;52(1):8-15.

Matsui H, Sakabe M, Sakata H, Yanagawa N, Ikeda K, Yamagishi T, Nakajima Y.
Induction of initial heart alpha-actin, smooth muscle alpha-actin, in chick pregastrula epiblast: the role of hypoblast and fibroblast growth factor-8.
Dev Growth Differ. 2008 Mar;50(3):143-57.

Saika S, Yamanaka O, Sumioka T, Miyamoto T, Miyazaki K, Okada Y, Kitano A, Shirai K, Tanaka S, Ikeda K.
Fibrotic disorders in the eye: targets of gene therapy.
Prog Retin Eye Res. 2008 Mar;27(2):177-96. Epub 2008 Feb 1. Review.

Otogawa K, Ogawa T, Shiga R, Nakatani K, Ikeda K, Nakajima Y, Kawada N.
Attenuation of acute and chronic liver injury in rats by iron-deficient diet.
Am J Physiol Regul Integr Comp Physiol. 2008 Feb;294(2):R311-20.

Matsubara T, Yoshinari K, Aoyama K, Sugawara M, Sekiya Y, Nagata K, Yamazoe Y. (2008)
Role of vitamin D receptor in the lithocholic acid-mediated CYP3A induction in vitro and in vivo.
Drug Metab Dispos 36(10):2058-2063

Shimada M, Matsuda T, Sato A, Akase T, Matsubara T, Nagata K, Yamazoe Y. (2008)
Expression of a skin cholesterol sulfotransferase, St2b2, is a trigger of epidermal cell differentiation.
Xenobiotica 38(12):1487-1499.

Taura K, De Minicis S, Seki E, Hatano E, Iwaisako K, Osterreicher CH, Kodama Y, Miura K, Ikai I, Uemoto S, Brenner DA.
Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosis.
Gastroenterology. 2008 Nov;135(5):1729-38. Epub 2008 Aug 3.

Iwaisako K, Hatano E, Taura K, Nakajima A, Tada M, Seo S, Tamaki N, Sato F, Ikai I, Uemoto S, Kinoshita M.
Loss of Sept4 exacerbates liver fibrosis through the dysregulation of hepatic stellate cells.
J Hepatol. 2008 Nov;49(5):768-78. Epub 2008 Jul 15.

Seo S, Hatano E, Higashi T, Nakajima A, Nakamoto Y, Tada M, Tamaki N, Iwaisako K, Mori A, Doi R, Ikai I, Uemoto S.
Fluorine-18 fluorodeoxyglucose positron emission tomography predicts lymph node metastasis, P-glycoprotein expression, and recurrence after resection in mass-forming intrahepatic cholangiocarcinoma.
Surgery. 2008 Jun;143(6):769-77. Epub 2008 Apr 11.

Tamaki N, Hatano E, Taura K, Tada M, Kodama Y, Nitta T, Iwaisako K, Seo S, Nakajima A, Ikai I, Uemoto S.
CHOP deficiency attenuates cholestasis-induced liver fibrosis by reduction of hepatocyte injury.
Am J Physiol Gastrointest Liver Physiol. 2008 Feb;294(2):G498-505. Epub 2008 Jan 3.

-2007

Kitano A, Saika S, Yamanaka O, Ikeda K, Okada Y, Shirai K, Reinach PS.
Emodin suppression of ocular surface inflammatory reaction.
Invest Ophthalmol Vis Sci. 2007 Nov;48(11):5013-22.

Yamanaka O, Saika S, Ohnishi Y, Kim-Mitsuyama S, Kamaraju AK, Ikeda K.
Inhibition of p38MAP kinase suppresses fibrogenic reaction in conjunctiva in mice.
Mol Vis. 2007 Sep 18;13:1730-9.

Okada Y, Ikeda K, Yamanaka O, Miyamoto T, Kitano A, Kao WW, Saika S.
TNFalpha suppression of corneal epithelium migration.
Mol Vis. 2007 Aug 14;13:1428-35.

Saika S, Yamanaka O, Okada Y, Miyamoto T, Kitano A, Flanders KC, Ohnishi Y, Nakajima Y, Kao WW, Ikeda K.
Effect of overexpression of PPARgamma on the healing process of corneal alkali burn in mice.
Am J Physiol Cell Physiol. 2007 Jul;293(1):C75-86.

Fujita S, Saika S, Kao WW, Fujita K, Miyamoto T, Ikeda K, Nakajima Y, Ohnishi Y.
Endogenous TNFalpha suppression of neovascularization in corneal stroma in mice.
Invest Ophthalmol Vis Sci. 2007 Jul;48(7):3051-5.

Saika S, Yamanaka O, Nishikawa-Ishida I, Kitano A, Flanders KC, Okada Y, Ohnishi Y, Nakajima Y, Ikeda K.
Effect of Smad7 gene overexpression on transforming growth factor beta-induced retinal pigment fibrosis in a proliferative vitreoretinopathy mouse model.
Arch Ophthalmol. 2007 May;125(5):647-54. PubMed PMID: 17502504.

Otogawa K, Kinoshita K, Fujii H, Sakabe M, Shiga R, Nakatani K, Ikeda K, Nakajima Y, Ikura Y, Ueda M, Arakawa T, Hato F, Kawada N.
Erythrophagocytosis by liver macrophages (Kupffer cells) promotes oxidative stress, inflammation, and fibrosis in a rabbit model of steatohepatitis: implications for the pathogenesis of human nonalcoholic steatohepatitis.
Am J Pathol. 2007 Mar;170(3):967-80.

Sakata H, Sakabe M, Matsui H, Kawada N, Nakatani K, Ikeda K, Yamagishi T, Nakajima Y.
Rho kinase inhibitor Y27632 affects initial heart myofibrillogenesis in cultured chick blastoderm.
Dev Dyn. 2007 Feb;236(2):461-72.

El-Karef A, Kaito M, Tanaka H, Ikeda K, Nishioka T, Fujita N, Inada H, Adachi Y, Kawada N, Nakajima Y, Imanaka-Yoshida K, Yoshida T.
Expression of large tenascin-C splice variants by hepatic stellate cells/myofibroblasts in chronic hepatitis C.
J Hepatol. 2007 Apr;46(4):664-73.

Kinoshita K, Iimuro Y, Otogawa K, Saika S, Inagaki Y, Nakajima Y, Kawada N, Fujimoto J, Friedman SL, Ikeda K.
Adenovirus-mediated expression of BMP-7 suppresses the development of liver fibrosis in rats.
Gut. 2007 May;56(5):706-14.

Nakatani K, Ikeda K, Nakajima Y, Seki S.
Expression of molecules with a potential for modulating interaction with extracellular matrices on hepatic stellate cells: neural cell adhesion molecules and osteonectin.
In: Dillon KH (ed), Trends in Liver Cirrhosis Research, Nova Science Publishers Inc, NY, pp 89-127, 2007

Kojima K, Nagata K, Matsubara T, Yamazoe Y. (2007)
Broad but distinct role of pregnane x receptor on the expression of individual cytochrome p450s in human hepatocytes.
Drug Metab Pharmacokinet 22:276-286

Kamiyama Y, Matsubara T, Yoshinari K, Nagata K, Kamimura H, Yamazoe, Y. (2007)
Role of human hepatocyte nuclear factor 4alpha in the expression of drug-metabolizing enzymes and transporters in human hepatocytes assessed by use of small interfering RNA.
Drug Metab Pharmacokinet 22(4):287-298.

Matsubara T, Noracharttiyapot W, Toriyabe T, Yoshinari K, Nagata K and Yamazoe Y. (2007)
Assessment of human pregnane X receptor-involvement in pesticide-mediated activation of CYP3A4 gene.
Drug Metab Dispos 35(5):728-733

-2006

Matsui H, Sakabe M, Sakata H, Nakatani K, Ikeda K, Fukui M, Ando K, Yamagishi T, Nakajima Y.
Heart myofibrillogenesis occurs in isolated chick posterior blastoderm: a culture model.
Acta Histochem Cytochem. 2006 Oct 30;39(5):139-44.

Sakabe M, Abe M, Nakatani K, Ikeda K, Yoshiyamal M, Nakajima Y.
[Dissection of the heart: a useful guide to understanding the three-dimensional gross anatomy].
Kaibogaku Zasshi. 2006 Dec;81(4):117-24. Japanese. PubMed PMID:17191690.

Kitano A, Saika S, Yamanaka O, Ikeda K, Reinach PS, Nakajima Y, Okada Y, Shirai K, Ohnishi Y.
Genipin suppresses subconjunctival fibroblast migration, proliferation and myofibroblast transdifferentiation.
Ophthalmic Res. 2006;38(6):355-60.

Kitano A, Saika S, Yamanaka O, Reinach PS, Ikeda K, Okada Y, Shirai K,Ohnishi Y.
Genipin suppression of fibrogenic behaviors of the alpha-TN4 lensepithelial cell line.
J Cataract Refract Surg. 2006 Oct;32(10):1727-35.

Sugawara K, Tsuruta D, Kobayashi H, Ikeda K, Hopkinson SB, Jones JC, Ishii M.
Spatial and temporal control of laminin-332 (5) and -511 (10) expression during induction of anagen hair growth.
J Histochem Cytochem. 2007 Jan;55(1):43-55.

Kinoshita K, Iimuro Y, Fujimoto J, Inagaki Y, Namikawa K, Kiyama H, Nakajima Y, Otogawa K, Kawada N, Friedman SL, Ikeda K.
Targeted and regulable expression of transgenes in hepatic stellate cells and myofibroblasts in culture and in vivo using an adenoviral Cre/loxP system to antagonise hepatic fibrosis.
Gut. 2007 Mar;56(3):396-404.

Yamanaka O, Ikeda K, Saika S, Miyazaki K, Ooshima A, Ohnishi Y.
Gene transfer of Smad7 modulates injury-induced conjunctival wound healing in mice.
Mol Vis.2006 Aug 1;12:841-51.

Yamanaka O, Saika S, Ikeda K, Miyazaki K, Ohnishi Y, Ooshima A.
Interleukin-7 modulates extracellular matrix production and TGF-beta signaling in cultured human subconjunctival fibroblasts.
Curr Eye Res. 2006 Jun;31(6):491-9.

Saika S, Ikeda K, Yamanaka O, Flanders KC, Okada Y, Miyamoto T, Kitano A, Ooshima A, Nakajima Y, Ohnishi Y, Kao WW.
Loss of tumor necrosis factor alpha potentiates transforming growth factor beta-mediated pathogenic tissue response during wound healing.
Am J Pathol. 2006 Jun;168(6):1848-60.

Nakatani K, Tanaka H, Ikeda K, Sakabe M, Kadoya H, Seki S, Kaneda K, Nakajima Y.
Expression of NCAM in activated portal fibroblasts during regeneration of the rat liver after partial hepatectomy.
Arch Histol Cytol. 2006 Mar;69(1):61-72.

Wang YQ, Luk JM, Chu AC, Ikeda K, Man K, Kaneda K, Fan ST.
TNP-470 blockage of VEGF synthesis is dependent on MAPK/COX-2 signaling pathway in PDGF-BB-activated hepatic stellate cells.
Biochem Biophys Res Commun. 2006 Mar3;341(1):239-44.

Sakabe M, Ikeda K, Nakatani K, Kawada N, Imanaka-Yoshida K, Yoshida T, Yamagishi T, Nakajima Y.
Rho kinases regulate endothelial invasion and migration during valvuloseptal endocardial cushion tissue formation.
Dev Dyn. 2006 Jan;235(1):94-104.

Izumi N, Mizuguchi S, Inagaki Y, Saika S, Kawada N, Nakajima Y, Inoue K, Suehiro S, Friedman SL, Ikeda K.
BMP-7 opposes TGF-beta1-mediated collagen induction in mouse pulmonary myofibroblasts through Id2.
Am J Physiol Lung Cell Mol Physiol. 2006 Jan;290(1):L120-6.

Saika S, Ikeda K, Yamanaka O, Flanders KC, Ohnishi Y, Nakajima Y, Muragaki Y, Ooshima A.
Adenoviral gene transfer of BMP-7, Id2, or Id3 suppresses injury-induced epithelial-to-mesenchymal transition of lens epithelium in mice.
Am J Physiol Cell Physiol. 2006 Jan;290(1):C282-9.

Sakata H, Sakabe M, Matsui H, Kawada N, Nakatani K, Ikeda K, Yamagishi T, Nakajima Y.
Rho kinase inhibitor Y27632 affects initial heart myofibrillogenesis in cultured chick blastoderm.
Dev Dynam 236(2): 461-472, 2006

Nakatani K, Tanaka H, Ikeda K, Sakabe M, Kadoya H, Seki S, Kaneda K, Nakajima Y.
Expression of NCAM in the activated portal fibroblasts during regeneration of the rat liver after partial hepatectomy. 
Arch Histol Cytol 69 (1): 61-72, 2006

Sakabe M, Abe M, Nakatani K, Ikeda K, Yoshiyamal M, Nakajima Y.
Dissection of the heart: a useful guide to understanding the three-dimensional gross anatomy.
Kaibogaku Zasshi 81(4): 117-124, 2006 (Japanese)

Matsui H, Sakabe M, Sakata H, Nakatani K, Ikeda K, Fukui M, Ando K, Yamagishi T, Nakajima Y.
Heart Myofibrillogenesis Occurs in Isolated Chick Posterior Blastoderm: A Culture Model.
Acta Histochemica et Cytochemica 39 (5): 139-144, 2006

Ishizaka S, Ouji Y, Yoshikawa M, Nakatani K.
Derivation and characterization of hepatocytes from embryonic stem cells in vitro. In: Turksen K (ed),
Methods in Molecular Biology, vol. 330: Embryonic Stem Cell Protocols, second edition, volume 2, Human Press Inc., Totowa, NJ, pp 387-399, 2006

Sakabe M, Ikeda K, Nakatani K, Kawada N, Imanaka-Yoshida K, Yoshida T, Yamagishi T, Nakajima Y.
Rho kinases regulate endothelial invasion and migration during valvuloseptal endothelial cushion tissue formation.
Dev Dynam 235 (1): 94-104, 2006

Noracharttiyapot W, Nagai Y, Matsubara T, Miyata M, Shimada M, Nagata K and Yamazoe Y. (2006)
Construction of several human-derived stable cell lines displaying distinct profiles of CYP3A4 induction.
Drug Metab Pharmacokinet 21(2):99-108.

-2005

Inagaki Y, Kushida M, Higashi K, Itoh J, Higashiyama R, Hong YY, Kawada N, Namikawa K, Kiyama H, Bou-Gharios G, Watanabe T, Okazaki I, Ikeda K.
Cell type-specific intervention of transforming growth factor beta/Smad signaling suppresses collagen gene expression and hepatic fibrosis in mice.
Gastroenterology. 2005 Jul;129(1):259-68.

Matsui H, Ikeda K, Nakatani K, Sakabe M, Yamagishi T, Nakanishi T, Nakajima Y.
Induction of initial cardiomyocyte alpha-actin--smooth muscle alpha-actin--in cultured avian pregastrula epiblast: a role for nodal and BMP antagonist.
Dev Dyn. 2005 Aug;233(4):1419-29. PubMed PMID: 15977172.

Saika S, Yamanaka O, Ikeda K, Kim-Mitsuyama S, Flanders KC, Yoo J, RobertsAB, Nishikawa-Ishida I, Ohnishi Y, Muragaki Y, Ooshima A.
Inhibition of p38MAP kinase suppresses fibrotic reaction of retinal pigment epithelial cells.
Lab Invest. 2005 Jul;85(7):838-50. PubMed PMID: 15924151.

Saika S, Ikeda K, Yamanaka O, Miyamoto T, Ohnishi Y, Sato M, Muragaki Y,Ooshima A, Nakajima Y, Kao WW, Flanders KC, Roberts AB.
Expression ofSmad7 in mouse eyes accelerates healing of corneal tissue after exposure to alkali.
Am J Pathol. 2005 May;166(5):1405-18. PubMed PMID: 15855641; PubMed Central PMCID:PMC1606395.

Saika S, Miyamoto T, Yamanaka O, Kato T, Ohnishi Y, Flanders KC, Ikeda K,Nakajima Y, Kao WW, Sato M, Muragaki Y, Ooshima A.
Therapeutic effect of topical administration of SN50, an inhibitor of nuclear factor-kappaB, in treatment of corneal alkali burns in mice.
Am J Pathol. 2005 May;166(5):1393-403. PubMed PMID:15855640; PubMed Central PMCID: PMC1606394.

Yamamoto S, Okuda T, Yamasaki K, Tanaka H, Takemura S, Minamiyama Y, Ikeda K,Hirohashi K, Suehiro S.
FK778 controls acute rejection after rat liver allotransplantation showing positive interaction with FK506.
Transplant Proc.2005 Jan-Feb;37(1):126-9. PubMed PMID: 15808570.

Saika S, Ikeda K, Yamanaka O, Flanders KC, Nakajima Y, Miyamoto T, Ohnishi Y,Kao WW, Muragaki Y, Ooshima A.
Therapeutic effects of adenoviral gene transfer of bone morphogenic protein-7 on a corneal alkali injury model in mice.
Lab Invest.2005 Apr;85(4):474-86. PubMed PMID: 15696184.

-2004

Yamamoto S, Okuda T, Yamasaki K, Tanaka H, Kubo S, Takemura S, Ikeda K,Minamiyama Y, Hirohashi K, Suehiro S.
FK778 and FK506 combination therapy to control acute rejection after rat liver allotransplantation.
Transplantation.2004 Dec 15;78(11):1618-25. PubMed PMID: 15591950.

Saika S, Ikeda K, Yamanaka O, Sato M, Muragaki Y, Ohnishi Y, Ooshima A,Nakajima Y, Namikawa K, Kiyama H, Flanders KC, Roberts AB.
Transient adenoviral gene transfer of Smad7 prevents injury-induced epithelial-mesenchymal transition of lens epithelium in mice.
Lab Invest. 2004 Oct;84(10):1259-70. PubMed PMID:15258599.

Matsui H, Ikeda K, Nakajima Y, Horikawa S, Imanishi Y, Kawada N.
Sulfur-containing amino acids attenuate the development of liver fibrosis in rats through down-regulation of stellate cell activation.
J Hepatol. 2004 Jun;40(6):917-25. PubMed PMID: 15158331.

Wang YQ, Luk JM, Ikeda K, Man K, Chu AC, Kaneda K, Fan ST.
Regulatory role of vHL/HIF-1alpha in hypoxia-induced VEGF production in hepatic stellate cells.
Biochem Biophys Res Commun. 2004 Apr 30;317(2):358-62. PubMed PMID: 15063765.

Matsubara T, Kim HJ, Miyata M, Shimada M, Nagata K and Yamazoe Y. (2004)
Isolation and characterization of a new major intestinal CYP3A form, CYP3A62, in the rat.
J Pharmacol Exp Ther 309(3):1282-1290.

Fujii H, Seki S, Nakatani K, Ikeda K, Ikemoto M, Nakajima Y, Arakawa T,Kaneda K.
Localization of lymphocyte apoptosis in murine lymphoid tissues after stimulation of natural killer T cells with alpha-galactosylceramide.
Arch Histol Cytol. 2003 Dec;66(5):397-406. PubMed PMID: 15018142.

Maeda N, Kawada N, Seki S, Ikeda K, Okuyama H, Hirabayashi J, Kasai KI,Yoshizato K.
Involvement of Galectin-1 and Galectin-3 in Proliferation and Migration of Rat Hepatic Stellate Cells in Culture.
Comp Hepatol. 2004 Jan 14;3Suppl 1:S10. PubMed PMID: 14960162; PubMed Central PMCID: PMC2410233.

Uyama N, Shimahara Y, Okuyama H, Kawada N, Kamo S, Ikeda K, Yamaoka Y.
Carbenoxolone inhibits DNA synthesis and collagen gene expression in rat hepatic stellate cells in culture.
J Hepatol. 2003 Nov;39(5):749-55. PubMed PMID:14568257.

Inagaki Y, Nemoto T, Kushida M, Sheng Y, Higashi K, Ikeda K, Kawada N,Shirasaki F, Takehara K, Sugiyama K, Fujii M, Yamauchi H, Nakao A, de Crombrugghe B, Watanabe T, Okazaki I.
Interferon alfa down-regulates collagen gene transcription and suppresses experimental hepatic fibrosis in mice.
Hepatology.2003 Oct;38(4):890-9. PubMed PMID: 14512876.

Kobayashi S, Seki S, Kawada N, Morikawa H, Nakatani K, Uyama N, Ikeda K,Nakajima Y, Arakawa T, Kaneda K.
Apoptosis of T cells in the hepatic fibrotic tissue of the rat: a possible inducing role of hepatic myofibroblast-like cells.
Cell Tissue Res. 2003 Mar;311(3):353-64. Epub 2003 Feb 5. PubMed PMID: 12658443.

Maeda N, Kawada N, Seki S, Arakawa T, Ikeda K, Iwao H, Okuyama H, Hirabayashi J, Kasai K, Yoshizato K.
Stimulation of proliferation of rat hepatic stellate cells by galectin-1 and galectin-3 through different intracellular signaling pathways.
J Biol Chem. 2003 May 23;278(21):18938-44. Epub 2003 Mar 19. PubMed PMID: 12646584.

Sato EF, Higashino M, Ikeda K, Wake R, Matsuo M, Utsumi K, Inoue M.
Oxidativestress-induced cell death of human oral neutrophils.
Am J Physiol Cell Physiol.2003 Apr;284(4):C1048-53. Epub 2002 Dec 18. PubMed PMID: 12490433.

Nakatani K, Seki S, Kawada N, Kitada T, Yamada T, Sakaguchi H, Kadoya H,Ikeda K, Kaneda K.
Expression of SPARC by activated hepatic stellate cells and its correlation with the stages of fibrogenesis in human chronic hepatitis.
Virchows Arch. 2002 Nov;441(5):466-74. Epub 2002 Apr 26. PubMed PMID: 12447677.

Saxena NK, Ikeda K, Rockey DC, Friedman SL, Anania FA.
Leptin in hepatic fibrosis: evidence for increased collagen production in stellate cells and lean littermates of ob/ob mice.
Hepatology. 2002 Apr;35(4):762-71. PubMed PMID:11915021.

Ikeda K, Wang LH, Torres R, Zhao H, Olaso E, Eng FJ, Labrador P, Klein R,Lovett D, Yancopoulos GD, Friedman SL, Lin HC.
Discoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagen.
J Biol Chem. 2002 May 24;277(21):19206-12. Epub 2002 Mar 7. PubMed PMID: 11884411.

Olaso E, Labrador JP, Wang L, Ikeda K, Eng FJ, Klein R, Lovett DH, Lin HC,Friedman SL.
Discoidin domain receptor 2 regulates fibroblast proliferation and migration through the extracellular matrix in association with transcriptional activation of matrix metalloproteinase-2.
J Biol Chem. 2002 Feb 1;277(5):3606-13.Epub 2001 Nov 26. PubMed PMID: 11723120.

Matsumoto S, Hirama T, Matsubara T, Nagata K and Yamazoe Y. (2002)
Involvement of CYP2J2 on the intestinal first-pass metabolism of antihistamine drug, astemizole.
Drug Metab Dispos 30(11):1240-1245.

Olaso E, Ikeda K, Eng FJ, Xu L, Wang LH, Lin HC, Friedman SL.
DDR2 receptor promotes MMP-2-mediated proliferation and invasion by hepatic stellate cells.
J Clin Invest. 2001 Nov;108(9):1369-78. PubMed PMID: 11696582; PubMed Central PMCID: PMC209436.

Kadoya H, Ikeda K, Nakatani K, Seki S, Kaneda K.
Cellular prion protein expression in non-ciliated epithelial cells (Clara cells) of proliferating bronchioles during bleomycin-induced pulmonary fibrosis in hamster.
Osaka City Med J. 2001 Jun;47(1):23-32. PubMed PMID: 11556389.

Okuno M, Akita K, Moriwaki H, Kawada N, Ikeda K, Kaneda K, Suzuki Y, Kojima S.
Prevention of rat hepatic fibrosis by the protease inhibitor, camostat mesilate, via reduced generation of active TGF-beta.
Gastroenterology. 2001 Jun;120(7):1784-800. PubMed PMID: 11375959.

Shimizu S, Yamada N, Sawada T, Ikeda K, Nakatani K, Seki S, Kaneda K,Hirakawa K.
Ultrastructure of early phase hepatic metastasis of human colon carcinoma cells with special reference to desmosomal junctions with hepatocytes.
Pathol Int. 2000 Dec;50(12):953-9. PubMed PMID: 11123761.

Shimizu S, Yamada N, Sawada T, Ikeda K, Kawada N, Seki S, Kaneda K, Hirakawa K.
In vivo and in vitro interactions between human colon carcinoma cells and hepatic stellate cells.
Jpn J Cancer Res. 2000 Dec;91(12):1285-95. PubMed PMID:11123428.

Kitada T, Seki S, Ikeda K, Nakatani K, Sakaguchi H, Kawada N, Kadoya H,Kaneda K.
Clinicopathological characterization of prion: a novel marker of activated human hepatic stellate cells.
J Hepatol. 2000 Nov;33(5):751-7. PubMed PMID: 11097483.

Wang YQ, Ikeda K, Ikebe T, Hirakawa K, Sowa M, Nakatani K, Kawada N, Kaneda K.
Inhibition of hepatic stellate cell proliferation and activation by the semisynthetic analogue of fumagillin TNP-470 in rats.
Hepatology. 2000 Nov;32(5):980-9.
PubMed PMID: 11050048.

Yachida S, Ikeda K, Kaneda K, Goda F, Maeba T, Maeta H.
Preventive effect of preoperative portal vein ligation on endotoxin-induced hepatic failure in hepatectomized rats is associated with reduced tumour necrosis factor alpha production.
Br J Surg. 2000 Oct;87(10):1382-90. PubMed PMID: 11044165.

Yamasaki M, Ikeda K, Nakatani K, Yamamoto T, Kawai Y, Hirohashi K, Kinoshita H, Kaneda K.
Phenotypical and morphological alterations to rat sinusoidal endothelial cells in arterialized livers after portal branch ligation.
Arch Histol Cytol. 1999 Dec;62(5):401-11. PubMed PMID: 10678569.

Kawada N, Ikeda K, Seki S, Kuroki T.
Expression of cyclins D1, D2 and E correlates with proliferation of rat stellate cells in culture.
J Hepatol. 1999 Jun;30(6):1057-64. PubMed PMID: 10406184.

Ikeda K, Wakahara T, Wang YQ, Kadoya H, Kawada N, Kaneda K.
In vitro migratory potential of rat quiescent hepatic stellate cells and its augmentation by cell activation.
Hepatology. 1999 Jun;29(6):1760-7. PubMed PMID: 10347119.

Ikeda K, Kawada N, Wang YQ, Kadoya H, Nakatani K, Sato M, Kaneda K.
Expression of cellular prion protein in activated hepatic stellate cells.
Am J Pathol. 1998 Dec;153(6):1695-700. PubMed PMID: 9846959; PubMed Central PMCID:PMC1866339.

Tsuji N, Kawada N, Ikeda K, Kinoshita H, Kaneda K.
Immunohistochemical and ultrastructural analyses of in situ activation of hepatic stellate cells around Propionibacterium acnes-induced granulomas in the rat liver.
J Submicrosc Cytol Pathol. 1997 Jan;29(1):125-33. PubMed PMID: 9066151.

Kawada N, Harada K, Ikeda K, Kaneda K.
Morphological study of endothelin-1-induced contraction of cultured hepatic stellate cells on hydrated collagen gels.
Cell Tissue Res. 1996 Dec;286(3):477-86. PubMed PMID: 8929350.

Ikeda K, Kubo S, Hirohashi K, Kinoshita H, Kaneda K, Kawada N, Sato EF, Inoue M.
Mechanism that regulates nitric oxide production by lipopolysaccharide-stimulated rat Kupffer cells.
Physiol Chem Phys Med NMR.1996;28(4):239-53. PubMed PMID: 9153798.

Ikeda K, Kinoshita H, Hirohashi K, Kubo S, Kaneda K.
The ultrastructure,kinetics and intralobular distribution of apoptotic hepatocytes after portal branch ligation with special reference to their relationship to necrotic hepatocytes.
Arch Histol Cytol. 1995 Jun;58(2):171-84. PubMed PMID: 7576869.

Takei Y, Kawano S, Nishimura Y, Goto M, Nagai H, Chen SS, Omae A, Fusamoto H,Kamada T, Ikeda K, et al.
Apoptosis: a new mechanism of endothelial and Kupffer cell killing.
J Gastroenterol Hepatol. 1995;10 Suppl 1:S65-7. PubMed PMID:8589347.

Shuto T, Kinoshita H, Hirohashi K, Kubo S, Fujio N, Tanaka H, Horii K, Hamba H, Takemura S, Ikeda K, et al.
[Second resected hepatocellular carcinoma of multicentric occurrence suspected by clinical follow-up].
Nippon Shokakibyo Gakkai Zasshi. 1993 Jun;90(6):1516-20. Japanese. PubMed PMID: 8392635.

Nakatani K, Okuyama H, Shimahara Y, Saeki S, Kim DH, Nakajima Y, Seki S, Kawada N, Yoshizato K.
Cytoglobin/STAP, its unique localization in splanchnic fibroblast-like cells and function in organ fibrogenesis.
Lab Invest, 84 (1): 91-101, 2004

Nakatani K, Kaneda K, Seki S, Nakajima Y.
Pit cells as liver-associated natural killer cells: morphology and function.
Med Electron Microsc 37 (1): 29-36, 2004

Fujii H, Seki S, Nakatani K, Ikeda K, Ikemoto M, Nakajima Y, Arakawa T, Kaneda K. Localization of lymphocyte apoptosis in murine lymphoid tissues after stimulation of natural killer T cells with alpha-galactosylceramide. Arch Histol Cytol,66 (5): 397-406, 2003

Kobayashi S, Seki S, Kawada N, Morikawa H, Nakatani K, Uyama N, Ikeda K, Nakajima Y, Arakawa T, Kaneda K.
Apoptosis of T cells in the hepatic fibrotic tissue of the rat: a possible inducing role of hepatic myofibroblast-like cells.
Cell Tissue Res, 311 (3): 353-364, 2003

Nakatani K, Seki S, Kawada N, Kitada T, Yamada T, Sakaguchi H, Kadoya H, Ikeda K, Kaneda K.
Expression of SPARC by activated hepatic stellate cells and its correlation with the stages of fibrogenesis in human chronic hepatitis.
Virchows Arch 441 (5): 466-474, 2002

Asahina K, Kawada N, Kristensen DB, Nakatani K, Seki S, Shiokawa M, Tateno C, Obara M, Yoshizato K.
Characterization of Human stellate cell activation-associated protein (STAP) and its expression in human liver.
Biochim Biophys Acta - Gene Structure and Expression 1577 (3): 471-475, 2002

Ishizaka S, Shiroi A, Kanda S, Yoshikawa M, Tsujinoue H, Kuriyama S, Hasuma T, Nakatani K, Takahashi K.
Development of hepatocytes from embryonic stem cells after transfection with the HNF-3b gene.
FASEB J 16 (11): 1444-1446, 2002

Hara M, Ono K, Hwang MW, Iwasaki A, Okada M, Nakatani K, Sasayama S, Matsumori A.
Evidence for a role of mast cells in the evolution to congestive heart failure.
J Exp Med 195 (3): 375-381, 2002

Kawada N, Kristensen DB, Asahina K, Nakatani K, Minamiyama Y, Seki S, Yoshizato K.
Characterization of a stellate cell activation-associated protein (STAP) with peroxidase activity found in rat hepatic stellate cells.
J Biol Chem 276 (27): 25318-25323, 2001

Nishimura H, Okazaki T, Tanaka Y, Nakatani K, Hara M, Matsumori A, Sasayama S, Mizoguchi A, Hiai H, Minato N, Honjo T.
Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice.
Science 291 (5502): 319-322, 2001

Kitada T, Seki S, Ikeda K, Nakatani K, Sakaguchi H, Kawada N, Kadoya H, Kaneda K.
Clinicopathlogical characterization of prion: a novel marker of activated human hepatic stellate cells.
J Hepatol 33 (5): 751-757, 2000

Wang CL, Umesaki N, Nakamura H, Tanaka T, Nakatani K, Sakaguchi I, Ogita S, Kaneda K.
Expression of vascular endothelial growth factor in granulated metrial gland cells in the pregnant mouse uterus.
Cell Tiss Res 300 (2): 285-293, 2000

Hara M, Matsumori A, Ono K, Kido H, Hwang MW, Miyamoto T, Iwasaki A, Okada M, Nakatani K, Sasayama S.
Mast cells cause apoptosis of cardiomyocytes and proliferation of other intramyocardial cells in vitro.
Circulation 100 (13): 1443-1449, 1999

Kakazu T, Hara J, Matsumoto T, Nakamura S, Oshitani N, Arakawa T, Kitano A, Nakatani K, Kinjo F, Kuroki T.
Type 1 T-helper cell predominance in granulomas of Crohn's disease.
Am J Gastroenterol 94 (8): 2149-2155, 1999

Ikeda K, Kawada N, Wang YQ, Kadoya H, Nakatani K, Sato M, Kaneda K.
Expression of cellular prion protein in activated hepatic stellate cells.
Am J Pathol 153 (3): 1695-1700, 1998

Kitada T, Seki S, Nakatani K, Kawada N, Kuroki T, Monna T.
Hepatic expression of c-Myb in chronic human liver disease.
Hepatology 26 (6): 1506-1512, 1997

Nakatani K,Seki S, Kawada N, Kobayashi K, Kaneda K.
Expression of neural cell adhesion molecule (N-CAM) in perisinusoidal stellate cells of the human liver.
Cell Tissue Res 283 (1): 159-165, 1996

Kawada N, Kuroki T, Kobayashi K, Inoue M, Nakatani K, Kaneda K, Nagata K.
Expression of heat-shock protein 47 in mouse liver.
Cell Tissue Res 284 (2): 341-346, 1996