‹ฦั(2004”Nˆศ‘Oj

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-English

2004”Nˆศ‘O

Yamamoto S, Okuda T, Yamasaki K, Tanaka H, Kubo S, Takemura S, Ikeda K,Minamiyama Y, Hirohashi K, Suehiro S.
FK778 and FK506 combination therapy to control acute rejection after rat liver allotransplantation.
Transplantation.2004 Dec 15;78(11):1618-25. PubMed PMID: 15591950.

Saika S, Ikeda K, Yamanaka O, Sato M, Muragaki Y, Ohnishi Y, Ooshima A,Nakajima Y, Namikawa K, Kiyama H, Flanders KC, Roberts AB.
Transient adenoviral gene transfer of Smad7 prevents injury-induced epithelial-mesenchymal transition of lens epithelium in mice.
Lab Invest. 2004 Oct;84(10):1259-70. PubMed PMID:15258599.

Matsui H, Ikeda K, Nakajima Y, Horikawa S, Imanishi Y, Kawada N.
Sulfur-containing amino acids attenuate the development of liver fibrosis in rats through down-regulation of stellate cell activation.
J Hepatol. 2004 Jun;40(6):917-25. PubMed PMID: 15158331.

Wang YQ, Luk JM, Ikeda K, Man K, Chu AC, Kaneda K, Fan ST.
Regulatory role of vHL/HIF-1alpha in hypoxia-induced VEGF production in hepatic stellate cells.
Biochem Biophys Res Commun. 2004 Apr 30;317(2):358-62. PubMed PMID: 15063765.

Matsubara T, Kim HJ, Miyata M, Shimada M, Nagata K and Yamazoe Y. (2004)
Isolation and characterization of a new major intestinal CYP3A form, CYP3A62, in the rat.
J Pharmacol Exp Ther 309(3):1282-1290.

Fujii H, Seki S, Nakatani K, Ikeda K, Ikemoto M, Nakajima Y, Arakawa T,Kaneda K.
Localization of lymphocyte apoptosis in murine lymphoid tissues after stimulation of natural killer T cells with alpha-galactosylceramide.
Arch Histol Cytol. 2003 Dec;66(5):397-406. PubMed PMID: 15018142.

Maeda N, Kawada N, Seki S, Ikeda K, Okuyama H, Hirabayashi J, Kasai KI,Yoshizato K.
Involvement of Galectin-1 and Galectin-3 in Proliferation and Migration of Rat Hepatic Stellate Cells in Culture.
Comp Hepatol. 2004 Jan 14;3Suppl 1:S10. PubMed PMID: 14960162; PubMed Central PMCID: PMC2410233.

Uyama N, Shimahara Y, Okuyama H, Kawada N, Kamo S, Ikeda K, Yamaoka Y.
Carbenoxolone inhibits DNA synthesis and collagen gene expression in rat hepatic stellate cells in culture.
J Hepatol. 2003 Nov;39(5):749-55. PubMed PMID:14568257.

Inagaki Y, Nemoto T, Kushida M, Sheng Y, Higashi K, Ikeda K, Kawada N,Shirasaki F, Takehara K, Sugiyama K, Fujii M, Yamauchi H, Nakao A, de Crombrugghe B, Watanabe T, Okazaki I.
Interferon alfa down-regulates collagen gene transcription and suppresses experimental hepatic fibrosis in mice.
Hepatology.2003 Oct;38(4):890-9. PubMed PMID: 14512876.

Kobayashi S, Seki S, Kawada N, Morikawa H, Nakatani K, Uyama N, Ikeda K,Nakajima Y, Arakawa T, Kaneda K.
Apoptosis of T cells in the hepatic fibrotic tissue of the rat: a possible inducing role of hepatic myofibroblast-like cells.
Cell Tissue Res. 2003 Mar;311(3):353-64. Epub 2003 Feb 5. PubMed PMID: 12658443.

Maeda N, Kawada N, Seki S, Arakawa T, Ikeda K, Iwao H, Okuyama H, Hirabayashi J, Kasai K, Yoshizato K.
Stimulation of proliferation of rat hepatic stellate cells by galectin-1 and galectin-3 through different intracellular signaling pathways.
J Biol Chem. 2003 May 23;278(21):18938-44. Epub 2003 Mar 19. PubMed PMID: 12646584.

Sato EF, Higashino M, Ikeda K, Wake R, Matsuo M, Utsumi K, Inoue M.
Oxidativestress-induced cell death of human oral neutrophils.
Am J Physiol Cell Physiol.2003 Apr;284(4):C1048-53. Epub 2002 Dec 18. PubMed PMID: 12490433.

Nakatani K, Seki S, Kawada N, Kitada T, Yamada T, Sakaguchi H, Kadoya H,Ikeda K, Kaneda K.
Expression of SPARC by activated hepatic stellate cells and its correlation with the stages of fibrogenesis in human chronic hepatitis.
Virchows Arch. 2002 Nov;441(5):466-74. Epub 2002 Apr 26. PubMed PMID: 12447677.

Saxena NK, Ikeda K, Rockey DC, Friedman SL, Anania FA.
Leptin in hepatic fibrosis: evidence for increased collagen production in stellate cells and lean littermates of ob/ob mice.
Hepatology. 2002 Apr;35(4):762-71. PubMed PMID:11915021.

Ikeda K, Wang LH, Torres R, Zhao H, Olaso E, Eng FJ, Labrador P, Klein R,Lovett D, Yancopoulos GD, Friedman SL, Lin HC.
Discoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagen.
J Biol Chem. 2002 May 24;277(21):19206-12. Epub 2002 Mar 7. PubMed PMID: 11884411.

Olaso E, Labrador JP, Wang L, Ikeda K, Eng FJ, Klein R, Lovett DH, Lin HC,Friedman SL.
Discoidin domain receptor 2 regulates fibroblast proliferation and migration through the extracellular matrix in association with transcriptional activation of matrix metalloproteinase-2.
J Biol Chem. 2002 Feb 1;277(5):3606-13.Epub 2001 Nov 26. PubMed PMID: 11723120.

Matsumoto S, Hirama T, Matsubara T, Nagata K and Yamazoe Y. (2002)
Involvement of CYP2J2 on the intestinal first-pass metabolism of antihistamine drug, astemizole.
Drug Metab Dispos 30(11):1240-1245.

Olaso E, Ikeda K, Eng FJ, Xu L, Wang LH, Lin HC, Friedman SL.
DDR2 receptor promotes MMP-2-mediated proliferation and invasion by hepatic stellate cells.
J Clin Invest. 2001 Nov;108(9):1369-78. PubMed PMID: 11696582; PubMed Central PMCID: PMC209436.

Kadoya H, Ikeda K, Nakatani K, Seki S, Kaneda K.
Cellular prion protein expression in non-ciliated epithelial cells (Clara cells) of proliferating bronchioles during bleomycin-induced pulmonary fibrosis in hamster.
Osaka City Med J. 2001 Jun;47(1):23-32. PubMed PMID: 11556389.

Okuno M, Akita K, Moriwaki H, Kawada N, Ikeda K, Kaneda K, Suzuki Y, Kojima S.
Prevention of rat hepatic fibrosis by the protease inhibitor, camostat mesilate, via reduced generation of active TGF-beta.
Gastroenterology. 2001 Jun;120(7):1784-800. PubMed PMID: 11375959.

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Shimizu S, Yamada N, Sawada T, Ikeda K, Nakatani K, Seki S, Kaneda K,Hirakawa K.
Ultrastructure of early phase hepatic metastasis of human colon carcinoma cells with special reference to desmosomal junctions with hepatocytes.
Pathol Int. 2000 Dec;50(12):953-9. PubMed PMID: 11123761.

Shimizu S, Yamada N, Sawada T, Ikeda K, Kawada N, Seki S, Kaneda K, Hirakawa K.
In vivo and in vitro interactions between human colon carcinoma cells and hepatic stellate cells.
Jpn J Cancer Res. 2000 Dec;91(12):1285-95. PubMed PMID:11123428.

Kitada T, Seki S, Ikeda K, Nakatani K, Sakaguchi H, Kawada N, Kadoya H,Kaneda K.
Clinicopathological characterization of prion: a novel marker of activated human hepatic stellate cells.
J Hepatol. 2000 Nov;33(5):751-7. PubMed PMID: 11097483.

Wang YQ, Ikeda K, Ikebe T, Hirakawa K, Sowa M, Nakatani K, Kawada N, Kaneda K.
Inhibition of hepatic stellate cell proliferation and activation by the semisynthetic analogue of fumagillin TNP-470 in rats.
Hepatology. 2000 Nov;32(5):980-9.
PubMed PMID: 11050048.

Yachida S, Ikeda K, Kaneda K, Goda F, Maeba T, Maeta H.
Preventive effect of preoperative portal vein ligation on endotoxin-induced hepatic failure in hepatectomized rats is associated with reduced tumour necrosis factor alpha production.
Br J Surg. 2000 Oct;87(10):1382-90. PubMed PMID: 11044165.

Yamasaki M, Ikeda K, Nakatani K, Yamamoto T, Kawai Y, Hirohashi K, Kinoshita H, Kaneda K.
Phenotypical and morphological alterations to rat sinusoidal endothelial cells in arterialized livers after portal branch ligation.
Arch Histol Cytol. 1999 Dec;62(5):401-11. PubMed PMID: 10678569.

Kawada N, Ikeda K, Seki S, Kuroki T.
Expression of cyclins D1, D2 and E correlates with proliferation of rat stellate cells in culture.
J Hepatol. 1999 Jun;30(6):1057-64. PubMed PMID: 10406184.

Ikeda K, Wakahara T, Wang YQ, Kadoya H, Kawada N, Kaneda K.
In vitro migratory potential of rat quiescent hepatic stellate cells and its augmentation by cell activation.
Hepatology. 1999 Jun;29(6):1760-7. PubMed PMID: 10347119.

Ikeda K, Kawada N, Wang YQ, Kadoya H, Nakatani K, Sato M, Kaneda K.
Expression of cellular prion protein in activated hepatic stellate cells.
Am J Pathol. 1998 Dec;153(6):1695-700. PubMed PMID: 9846959; PubMed Central PMCID:PMC1866339.

Tsuji N, Kawada N, Ikeda K, Kinoshita H, Kaneda K.
Immunohistochemical and ultrastructural analyses of in situ activation of hepatic stellate cells around Propionibacterium acnes-induced granulomas in the rat liver.
J Submicrosc Cytol Pathol. 1997 Jan;29(1):125-33. PubMed PMID: 9066151.

Kawada N, Harada K, Ikeda K, Kaneda K.
Morphological study of endothelin-1-induced contraction of cultured hepatic stellate cells on hydrated collagen gels.
Cell Tissue Res. 1996 Dec;286(3):477-86. PubMed PMID: 8929350.

Ikeda K, Kubo S, Hirohashi K, Kinoshita H, Kaneda K, Kawada N, Sato EF, Inoue M.
Mechanism that regulates nitric oxide production by lipopolysaccharide-stimulated rat Kupffer cells.
Physiol Chem Phys Med NMR.1996;28(4):239-53. PubMed PMID: 9153798.

Ikeda K, Kinoshita H, Hirohashi K, Kubo S, Kaneda K.
The ultrastructure,kinetics and intralobular distribution of apoptotic hepatocytes after portal branch ligation with special reference to their relationship to necrotic hepatocytes.
Arch Histol Cytol. 1995 Jun;58(2):171-84. PubMed PMID: 7576869.

Takei Y, Kawano S, Nishimura Y, Goto M, Nagai H, Chen SS, Omae A, Fusamoto H,Kamada T, Ikeda K, et al.
Apoptosis: a new mechanism of endothelial and Kupffer cell killing.
J Gastroenterol Hepatol. 1995;10 Suppl 1:S65-7. PubMed PMID:8589347.

Shuto T, Kinoshita H, Hirohashi K, Kubo S, Fujio N, Tanaka H, Horii K, Hamba H, Takemura S, Ikeda K, et al.
[Second resected hepatocellular carcinoma of multicentric occurrence suspected by clinical follow-up].
Nippon Shokakibyo Gakkai Zasshi. 1993 Jun;90(6):1516-20. Japanese. PubMed PMID: 8392635.

Nakatani K, Okuyama H, Shimahara Y, Saeki S, Kim DH, Nakajima Y, Seki S, Kawada N, Yoshizato K.
Cytoglobin/STAP, its unique localization in splanchnic fibroblast-like cells and function in organ fibrogenesis.
Lab Invest, 84 (1): 91-101, 2004

Nakatani K, Kaneda K, Seki S, Nakajima Y.
Pit cells as liver-associated natural killer cells: morphology and function.
Med Electron Microsc 37 (1): 29-36, 2004

Fujii H, Seki S, Nakatani K, Ikeda K, Ikemoto M, Nakajima Y, Arakawa T, Kaneda K. Localization of lymphocyte apoptosis in murine lymphoid tissues after stimulation of natural killer T cells with alpha-galactosylceramide. Arch Histol Cytol,66 (5): 397-406, 2003

Kobayashi S, Seki S, Kawada N, Morikawa H, Nakatani K, Uyama N, Ikeda K, Nakajima Y, Arakawa T, Kaneda K.
Apoptosis of T cells in the hepatic fibrotic tissue of the rat: a possible inducing role of hepatic myofibroblast-like cells.
Cell Tissue Res, 311 (3): 353-364, 2003

Nakatani K, Seki S, Kawada N, Kitada T, Yamada T, Sakaguchi H, Kadoya H, Ikeda K, Kaneda K.
Expression of SPARC by activated hepatic stellate cells and its correlation with the stages of fibrogenesis in human chronic hepatitis.
Virchows Arch 441 (5): 466-474, 2002

Asahina K, Kawada N, Kristensen DB, Nakatani K, Seki S, Shiokawa M, Tateno C, Obara M, Yoshizato K.
Characterization of Human stellate cell activation-associated protein (STAP) and its expression in human liver.
Biochim Biophys Acta - Gene Structure and Expression 1577 (3): 471-475, 2002

Ishizaka S, Shiroi A, Kanda S, Yoshikawa M, Tsujinoue H, Kuriyama S, Hasuma T, Nakatani K, Takahashi K.
Development of hepatocytes from embryonic stem cells after transfection with the HNF-3b gene.
FASEB J 16 (11): 1444-1446, 2002

Hara M, Ono K, Hwang MW, Iwasaki A, Okada M, Nakatani K, Sasayama S, Matsumori A.
Evidence for a role of mast cells in the evolution to congestive heart failure.
J Exp Med 195 (3): 375-381, 2002

Kawada N, Kristensen DB, Asahina K, Nakatani K, Minamiyama Y, Seki S, Yoshizato K.
Characterization of a stellate cell activation-associated protein (STAP) with peroxidase activity found in rat hepatic stellate cells.
J Biol Chem 276 (27): 25318-25323, 2001

Nishimura H, Okazaki T, Tanaka Y, Nakatani K, Hara M, Matsumori A, Sasayama S, Mizoguchi A, Hiai H, Minato N, Honjo T.
Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice.
Science 291 (5502): 319-322, 2001

Kitada T, Seki S, Ikeda K, Nakatani K, Sakaguchi H, Kawada N, Kadoya H, Kaneda K.
Clinicopathlogical characterization of prion: a novel marker of activated human hepatic stellate cells.
J Hepatol 33 (5): 751-757, 2000

Wang CL, Umesaki N, Nakamura H, Tanaka T, Nakatani K, Sakaguchi I, Ogita S, Kaneda K.
Expression of vascular endothelial growth factor in granulated metrial gland cells in the pregnant mouse uterus.
Cell Tiss Res 300 (2): 285-293, 2000

Hara M, Matsumori A, Ono K, Kido H, Hwang MW, Miyamoto T, Iwasaki A, Okada M, Nakatani K, Sasayama S.
Mast cells cause apoptosis of cardiomyocytes and proliferation of other intramyocardial cells in vitro.
Circulation 100 (13): 1443-1449, 1999

Kakazu T, Hara J, Matsumoto T, Nakamura S, Oshitani N, Arakawa T, Kitano A, Nakatani K, Kinjo F, Kuroki T.
Type 1 T-helper cell predominance in granulomas of Crohn's disease.
Am J Gastroenterol 94 (8): 2149-2155, 1999

Ikeda K, Kawada N, Wang YQ, Kadoya H, Nakatani K, Sato M, Kaneda K.
Expression of cellular prion protein in activated hepatic stellate cells.
Am J Pathol 153 (3): 1695-1700, 1998

Kitada T, Seki S, Nakatani K, Kawada N, Kuroki T, Monna T.
Hepatic expression of c-Myb in chronic human liver disease.
Hepatology 26 (6): 1506-1512, 1997

Nakatani K,Seki S, Kawada N, Kobayashi K, Kaneda K.
Expression of neural cell adhesion molecule (N-CAM) in perisinusoidal stellate cells of the human liver.
Cell Tissue Res 283 (1): 159-165, 1996

Kawada N, Kuroki T, Kobayashi K, Inoue M, Nakatani K, Kaneda K, Nagata K.
Expression of heat-shock protein 47 in mouse liver.
Cell Tissue Res 284 (2): 341-346, 1996