研究の内容と主な業績

Nakajima, K. and R. Wall. Interleukin-6 signals activating junB and TIS11 gene transcription in a B-cell hybridoma. Mol. Cell. Biol. 11: 1409-1418. 1991. （膜から核に至までのIL-6伝達系ー記念碑的仕事）

Nakajima, K., T. Kusafuka, T. Takeda, Y. Fujitani, K. Nakae and T. Hirano. Identification of a novel interleukin 6 responsive element containing an Ets-binding site and a CRE-like site in the junB promoter. Mol. Cell. Biol. 13: 3027-3041. 1993.（junBプロモーター上のIL-6応答領域の決定）

Fujitani, Y., K. Nakajima, H. Kojima, K. Nakae, T. Takeda and T. Hirano. Transcriptional activation of the IL-6 response element in the junB promoter is mediated by multiple Stat family proteins. Biochem. Biophys. Res. Commun. 202; 1181-1187. 1994.（主要なシグナル伝達性転写因子STAT3の同定）

Nakae, K., K. Nakajima, J. Inazawa, T. Kitaoka and T. Hirano. ERM, a PEA3 subfamily of Ets transcription factors, can cooperate with c-Jun. J. Biol. Chem. 270: 23795-23800. 1995（新規ETSファミリー転写因子ERMのcDNAクローニングと機能の特徴）

Kojima, H., K. Nakajima, and T. Hirano. IL-6-inducible complexes on an IL-6 response element of the junB promoter contain Stat3 and 36 kDa CRE-like site binding protein(s). Oncogene 12: 547-554. 1996.（STAT3と協調するCRE結合蛋白p36の存在)

Yamanaka, Y., K. Nakajima, T. Fukada, M. Hibi, and T. Hirano. Differentiation and growth arrest signals generate through the cytoplasmic region of gp130 that is essential for Stat3 activation. EMBO J. 15: 1557-1565. 1996

Nakajima, K., Y. Yamanaka, K. Nakae, H. Kojima, M. Ichiba, N. Kiuchi, T. Kitaoka, T. Fukada, M. Hibi and T. Hirano. A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells. EMBO J. 15:3651-3658. 1996 (STAT3は、IL-6によるM１細胞増殖停止、マクロファージ分化決定において重要な働きをする。）

Fukada, T., M. Hibi, Y. Yamanaka, M. Takahashi-Tezuka, Y. Fujitani, T. Yamaguchi, K. Nakajima, and T. Hirano. Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of Stat3 in anti-apoptosis. Immunity 5: 449-460. 1996（細胞生存、細胞増殖におけるSTAT3の重要な役割）

Ihara, S., K. Nakajima, T. Fukada, M. Hibi, S. Nagata, T. Hirano, snd Y. Fukui. Dual control of neurite outgrowth by Stat3 and MAP kinase in PC12 cells stimulated with intrleukin-6. EMBO J. 16: 5345-5352. 1997.（PC１２神経突起伸張におけるgp130シグナルの解析、STAT3の分化抑制作用）

Narimatsu, M., K. Nakajima, M. Ichiba and T. Hirano. Association of Stat3-dependent transcriptional activation of p19INK4D with the IL-6-induced growth arrest. Biochem. Biophys. Res. Commun. 238:764-768. 1997.（増殖停止に関与するSTAT3下流遺伝子）

Ichiba, M., K. Nakajima, Y. Yamanaka, N. Kiuchi, and T. Hirano. Autoregulation of the Stat3 gene through cooperation woth a CRE site binding protein. J. Biol. Chem. 273: 6132-8. 1998. (STAT3によるstat3遺伝子転写活性化ーautoregulatory loopの存在証明)

中嶋弘一　STAT3の活性制御機構と細胞増殖、分化における役割ーStat3は分子スイッチとなりうるかー　実験医学16: 480-486. 1998. (STAT3に関する総説）

中嶋弘一　JAK/STATシグナル伝達系における最近の進歩　日本臨床　1763-1772, 1998 （Jak/Stat一般の総説）

STATの核移行については、関元、米田らのつぎの２論文を参照されたし。

Sekimoto, T., K. Nakajima, T. Tachibana, T. Hirano, and Y. Yoneda. Interferon-γ-dependent nuclear translocation import of Stat1 is mediated by the GTPase activity of Ran/TC4. J. Biol. Chem. 271; 31017-31020, 1996. (PDF)

Sekimoto, T., N. Imamoto, K. Nakajima, T. Hirano, and Y. Yoneda. Extracellular signal-dependent nuclear import of stat1 is mediated by nuclear pore-targeting complex formation with NPI-1, not Rch1. EMBO J. 16:7067-7077. 1997. (PDF)

Kiuchi, N., K. Nakajima, M. Ichiba, T. Fukada, M. Narimatsu, K. Mizuno, M. Hibi and T. Hirano. STAT3 is required for the gp130-mediated full activation of the c-myc gene. J. Exp. Med. 189: 63-73.1999 (STAT3がc-myc遺伝子プロモーター上のE2F結合部位に直接作用し、c-myc遺伝子転写活性化をもたらすことを示した。STAT Family蛋白とc-myc遺伝子発現との連関を示す最初の報告。）(PDF)

Narimatsu, M., H. Maeda, S. Itoh, T. Atsumi, T. Ohtani, K. Nishida, M. Itoh, D. Kamimura, S.-J. Park, K. Mizuno, J. Miyazaki, M. Hibi, K. Ishihara, K. Nakajima and T. Hirano. Tissue-specific autoregulation of the stat3 gene and its role in interleukin 6-induced survival signals in T cells. Mol. Cell. Biol. 21:6615-6625, 2001, 2001

Abe, K., M. Hirai, K. Mizuno, N. Higashi, T. Sekimoto, T. Miki, T. Hirano and K. Nakajima. The YXXQ motif in gp130 is crucial for STAT3 phosphorylation at Ser727 through an H7-sensitive kinase pathway. Oncogene 20: 3464-3474. 2001.（IL-6受容体分子gp130のYXXQモチーフはこれまでSTAT3を受容体に引き寄せることにのみ働くとされていたが、ここではじめてYXXQモチーフがもう一つの作用、すなわち新規H7感受性伝達系を通じてSTAT3のSer727をリン酸化することで転写活性を高める働きをもつことを示した。）