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最近の業績




Notomi T, Kuno M, Hiyama A, Ezura Y and Noda M. Role of lysosomal channel protein TPC2 in osteoclast differentiation and bone remodeling under normal and low-magnesium conditions. J Biol Chem (in press)

Tsujikawa S, Matsuura T, Hori K, Mori T, Kuno M and Nishikawa K. Superior efficacy of lipid emulsion infusion over serum alkalinization in reversing amitriptyline-induced cardiotoxicity in guinea pig. Anesthesia & Analgesia (in press).

Li G, Miura K and Kuno M. Extracellular phosphates enhance activities of voltage-gated proton channels and production of reactive oxygen species in murine osteoclast-like cells. Pflugers Archiv-Eur J Physiol. 469:279-292, 2017.


Liu S, Sahid MNA, Takemasa E, Kiyoi T, Kuno M, Oshima Y and Maeyama K. CRAC3 regulates the stability of non-excitable vesicle fusion pores in a Ca2+-independent manner via molecular interaction with syntaxin4. Scientific Reports 6: 28133, 2016.



久野みゆき.「電位依存性プロトンチャネル」 腎と透析 80巻3号、p397−401, 2016. 東京医学社.

Kuno M, Li G, Moriura Y, Hino Y, Kawawaki J and Sakai H. Acid-inducible proton influx currents in the plasma membrane of murine osteoclast-like cells. Pflugers Archiv - Eur J Physiol 468: 837-847, 2016.

Hori K, Matsuura T, Tsujikawa S, Mori T, Kuno M, Nishikawa K. The significant contribution of the partitioning effect in lipid resuscitation for bupivacaine-induced cardiotoxicity: Evaluation by using centrifuged solution in vivo and in isolated hearts. Br J Anesth 115: 935-937, 2015.

Notomi T, Kuno M, Hiyama A, Ezura Y, Honma M, Ishizuka T, Ohura K, Yao H and Noda M. Membrane depolarization regulates intracellular RANKL transport in non-excitable osteoblasts. Bone 81: 306-314, 2015.

Notomi T, Kuno M, Hiyama A, Ohura K, Noda M, Skerry TM. Zinc-induced effects on osteoclastogenesis involve activation of hyperpolarization-activated cyclic nucleotide modulated channels via changes in membrane potentials. Journal of Bone and Mineral Research. 30: 1618-1626, 2015.PubMed

久野みゆき.「V-ATPase」(骨ペディア/骨疾患・骨代謝キーワード事典). 羊土社. 2015.

Liu S, Watanabe S, Shoudou M, Kuno M, Maeyama K. Upregulation of sotre-operated Ca2+ entry in the naive CD4(+) T cells with aberrant cytokine releasing in active rheumatoid arthritis. Immunol Cell Biol 92: 752-760, 2014.PubMed

Hori K, Kuno M, Nishikawa K. Lipid emulsion increases the fast Na+ currents and reverses the bupivacaine-induced block: A new aspect of lipid resuscitation? Anesthesiology 121: 903-904, 2014.PubMed

Sakai H, Li G, Hino Y, Moriura Y, Kawawaki J, Sawada M and Kuno M. Increases in intracellular pH facilitate endocytosis and decrease availability of voltage-gated proton channels in osteoclasts and microglia. Journal of Physiology (Lond) 591: 5851-5866, 2013.PubMed

Hori K, Matsuura T, Mori T, Kuno M, Narahashi T, Sawada M, Nishikawa K. The effect of lipid emulsion on intracellular bupivacaine as a mechanism of lipid resustation: an electrophysiological study using voltage-gated proton channels. Anesthesia and Analgesia 117: 1293-1301, 2013.PubMed

Hasaka M, Mori T, Matsuura T, Narahashi T, Kuno M, Asada A and Nishikawa K. Effects of general anaesthetics on P2X4 receptors in a mouse cell line. Neuroreport 23: 601-605, 2012.PubMed

Matsuura, T, Mori T, Hasaka M, Kuno M, Kawawaki J, Nishikawa K, Narahashi T, Sawada M and Asada A. Inhibition of voltage-gated proton channels by local anaesthetics in GMI-R1 rat microglia. Journal of Physiology (Lond) 590: 827-843, 2012. PubMed

久野みゆき。キーワード解説:プロトンポンプとプロトンチャネル。日本薬理学雑誌 138: 219-220, 2011.

Sakai, H., Moriura, Y., Notomi, T., Kawawaki, J., Onishi, K. and Kuno, M. Phospholipase C-dependent Ca2+ sensing pathways leading to endocytosis and inhibition of the plasma membrane vacuolar H+-ATPase in osteoclasts. American Journal of Physiology (Cell Physiology) 299: C570-C578, 2010.PubMed

Kuno, M., Ando, H., Morihata, H., Sakai, H., Mori, H., Sawada, M. and Oiki, S. Temperature dependence of proton permeation through a voltage-gated proton channel. Journal of General Physiology 134: 191-205, 2009. PubMed

Morihata, H., Kawawaki, J., Okina, M., Sakai, H., Notomi, T., Sawada, M. and Kuno, M. Early and late activation of the voltage-gated proton channel during lactic acidosis through pH-dependent and -independent mechanisms. Pflugers Archiv-European Journal of Physiology (Lond) 455: 829-838, 2008 PubMed.

Nakanishi, M., Mori, T., Nishikawa, K., Sawada, M., Kuno, M. and Asada, A. Effects of General Anesthetics on P2X7 and P2Y Receptors in a Rat Microglial Cell Line. Anestheshia and Analgesia, 104: 1136-1144, 2007. PubMed

Sakai, H., Kawawaki, J., Moriura, Y., Mori, H., Morihata, H. and Kuno, M.
pH dependence and inhibition by extracellular calcium of proton currents via plasmalemmal vacuolar-type H+-ATPase in murine osteoclasts. J. Physiol. (Lond) 576.2: 417-425, 2006.
PubMed

Kawajiri, M., Okano, Y., Kuno, M., Tokuhara, D., Hase, Y., Inada, H., Tashiro, F., Miyazaki, J. and Yamano, T. Unregulated insulin secretion by pancreatic beta-cells in hyperinsulinism/hyperammonemia syndrome: Role of gluatmate dehydrogenase, ATP-sensitive potassium channel, and nonselective cation channel. Pediatric Res. 59: 359-364, 2006.
PubMed

Ando, H., Kuno, M., Shimizu, H., Muramatus, I. and Oiki, S. Coupled K+ - water flux through the HERG potassium channel measured by an osmotic pulse method. J. Gen. Physiol. 126: 529-538, 2005.
PubMed

久野みゆき・安藤啓司・杉原泉・秋田恵一。 人体の正常構造と機能: IX 神経系(2) 日本医事新報社, 2005.

Mori, H., Sakai, H., Morihata, H., Kawawaki, J., Amano, H., Yamano, T. and Kuno, M. Regulatory mechanisms and physiological relevance of a voltage-gated H+ channel in murine osteoclasts: Phorbol myristate acetate induces cell acidosis and the channel activation. J. Bone Miner. Res. 18:2069-2076, 2003.
PubMed

森泰生、稲垣千代子、久野みゆき、井上隆司、岡田泰伸、今泉祐治。「薬理学のQOLへの貢献2: 細胞増殖・分化・死を制御するイオンメカニズムと創薬」日薬理誌 (Folia Pharmacol. Jpn.) 122, 201-214, 2003.

Mori, H., Sakai, H., Morihata, H., Yamano, T. and Kuno, M.
A voltage-gated H+ channel is a powerful mechanism for pH homeostasis in murine osteoclasts. Kobe J. Med. Sci. 48:87-96, 2002.
PubMed

Shimakawa, S., Suzuki, S., Miyamoto, R., Takitani, K., Tanaka, K., Tanabe, T., Wakamiya, E., Nakamura, F., Kuno, M., Matsuura, S., Watanabe, Y. and Tamai. Neuropilin-2 is overexpressed in the rat brain after limbic seizures. Brain Res. 956:67-73, 2002.
PubMed

Sakuta, K., Sakai, H., Mori, H., Morihata, H. and Kuno, M. Na+-dependence of extracellular calcium-sensing mechanisms leading to activation of an outwardly rectifying Cl- channel in murine osteoclasts. Bone 31: 374-380, 2002.
PubMed

Sakuta, K., Morihata, H., Mori, H., Sakai, H. and Kuno, M. Cell volume as an intermediate signal leading to activation of a Cl- channel in extracellular-calcium sensing of murine osteoclasts. Osaka City Med. J. 48:29-38, 2002.
PubMed

酒井啓、久野みゆき。骨リモデリングとイオンシグナル:骨の細胞応答におけるチャネル・トランスポーターの役割。医学のあゆみ。Vol. 199: 199-202. 2001.

Nakamura, F., Morihata, H., Matsuura, S. and Kuno, M. Post-cultured development of basic electrophysiological properties of spinal neruons obtained from rat embryo. Brain Res. 905:245-249, 2001.
PubMed

久野みゆき。骨代謝研究の歴史12:細胞内カルシウム研究史。Clinical Calcium 11:651‐654, 2001.

Morihata, H., Nakamura, F., Tsutada, T. and Kuno, M. Potentiation of a voltage-gated proton current in acidosis-induced swelling of rat microglia. J. Neurosci. 20:7220-7227, 2000.
PubMed

Morihata, H., Kawawaki, J., Sakai, H., Sawada, M., Tsutada, T. and Kuno, M. Temporal fluctuations of voltage-gated proton currents in rat spinal microglia via pH-dependent and -independent mechanisms. Neurosci. Res. 38: 265-271, 2000.
PubMed

酒井啓、作田浩一、森啓之、森畑宏一、久野みゆき。「カルシウムと骨の細胞」 Clinical Calcium 10:504-510, 2000.

Sakai, H., Nakamura, F., Sakuta, K., Mori, H. and Kuno, M. Co-operative action of hypotonic stress and a rise in external Ca2+ on Cl- currents of murine osteoclasts. In: Control and Diseases of Sodium Dependent Transport proteins and Ion Channels (Excerpta Medica International Congress Series 1208), edited by Y. Suketa et al. Elsevier Science, p273-4, 2000.

Morihata, H., Nakamura, F. and Kuno, M. Cell swelling-associated activation of a voltage-gated proton (H+) current in rat microglia. In: Control and Diseases of Sodium Dependent Transport proteins and Ion Channels (Excerpta Medica International Congress Series 1208), edited by Y. Suketa et al., Elsevier, p125-6, 2000.

Sakai, H., Nakamura, F. and Kuno, M. Synergetic activation of outwardly rectifying Cl- currents by hypotonic stress and external Ca2+ in murine osteoclasts. J. Physiol. Lond. 515.1: 157-168, 1999.
PubMed

久野みゆき、中村夫左央、森畑宏一、酒井啓。グリアのもつイオンチャネル。Clinical Neuroscience 17: 1009-1012, 1999.

Kuno, M., Kawawaki, J. and Nakamura, F. A highly temperature-sensitive proton current in mouse bone marrow-derived mast cells. J. Gen. Physiol. 109: 731-740, 1997.
PubMed

Shibata, T., Sakai, H., Nakamura, F., Shioi, A. and Kuno, M. Differential effect of high extracellular Ca2+ on K+ and Cl- conductances in murine osteoclasts. J. Memb. Biol. 158:59-67, 1997.
PubMed

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