中島裕司 （なかじまゆうじ）
Yuji Nakajima
【現在の研究テーマ】１）弁や中隔原基である心内膜床形成の分子機構、２）予定心臓中胚葉と初期心筋分化機構、３）冠状動脈の発生機構、３）心筋組織幹細胞の発生動態とモデル培養系の確立
【参考図書】中島裕司、循環器系形成、わかる実験医学シリーズ 発生生物学がわかる（上野直人、野地澄晴 編集）羊土社p94-99, 2004
心筋組織幹細胞の発生動態とモデル培養系の確立。
心臓発生とその分子機構、中島裕司、循環器形成、発生生物学がわかる（羊土社）より
発表論文
1.
Matsui H, Sakabe M, Sakata H, Yanagawa N, Ikeda K, Yamagishi T,
Nakajima Y. Induction of initial heartα-actin, smooth muscleα-actin, in chick pregastrula epiblast: The role of hypoblast and fibroblast growth factor-8. Develop Growth Differ 50 (3): 143-157, 2008
1. Sakata H, Sakabe M, Matsui H, Kawada N, Nakatani K, Ikeda K, Yamagishi T, Nakajima Y. Rho kinase inhibitor Y27632 affects initial heart myofibrillogenesis in cultured chick blastoderm. Dev Dynam 236(2): 461-472, 2007
2. Sakabe
M, Ikeda K, Nakatani K, Kawada N, Imanaka-Yoshida K, Yoshida T, Yamagishi
T, Nakajima Y. Rho kinases regulate endothelial invasion and migration
during valvuloseptal endothelial cushion tissue formation. Dev Dynam
235 (1): 94-104, 2006
3. Sakabe M, Matsui H, Sakata H, Ando K, Yamagishi T, Nakajima Y.
Understanding heart development and congenital heart defects through
developmental biology: A segmental approach. Congenit Anom
45(4):107-18, 2005
4. Matsui H, Ikeda K, Nakatani K, Sakabe M, Yamagishi T, Nakanishi T,
Nakajima Y. Induction of initial cardiomyocyte a-actin - smooth muscle
a-actin - in cultured avian pregastrula epiblast: a role for nodal and
BMP antagonist. Dev Dyn 233 (4): 1419-1429, 2005
5. Yamagishi T, Nakajima Y, Ando K, Nakamura H. Msx1 expression during
chick heart development: possible role. in Cardiovascular Development
and Congenital Malformation ﾐ Molecular and Genetic Mechanisms. Artman
M. Benson DW, Srivastava D, Nakazawa M (eds), Blackwell Futura (Massachusetts),
pp69-71, 2005.
6. Ando K, Nakajima Y, Yamagishi T, Yamamoto S, Nakamura H. Development of proximal coronary artery. in Cardiovascular Development and Congenital Malformation ﾐ Molecular and Genetic Mechanisms. Artman M. Benson DW, Srivastava D, Nakazawa M (eds), Blackwell Futura (Massachusetts), pp109-111, 2005.
7. Yamagishi T, Nakajima Y, Nishimatsu S, Nohno T, Ando K, Nakamura H.
Expression of tbx20 RNA during chick heart development. Dev Dyn 230, 576-580,
2004.
8. Ando K, Nakajima Y, Yamagishi T, Yamamoto S, Nakamura H. Development
of Proximal Coronary Arteries in Quail Embryonic Heart: Multiple Capillaries
Penetrating the Aortic Sinus Fuse to Form Main Coronary Trunk . Circ Res
94: 346 ﾐ 352, 2004
9. Y Nakajima, T Yamagishi, K Ando, H Nakamura. Significance of Bone
Morphogenetic Protein-4 Function in the Initial Myofibrillogenesis of
Chick Cardiogenesis Dev Biol 245:291-303, 2002
10. Yamagishi T, Nakajima Y, Nishimatsu S, Nohno T, Ando K, Nakamura H.
Expression of bone morphogenetic protein-5 gene during chick heart development:
possible roles in valvuloseptal endocardial cushion formation. Ant Rec
264:313-316, 2001
11. Nakajima Y, Yoshimura K, Nomura M, Nakamura H. Expression of HNK1
epitope by the cardiomyocytes of the early embryonic chick:: in situ and
in vitro study. Anat Rec 263:326-333, 2001
12. Nakajima Y, Yamagishi T, Hokari S, Nakamura H. Mechanisms involved
in valuvuloseptal endocardial cushion formation in early cardiogenesis:
roles of transforming growth factor (TGF)-__and bone morphogenetic protein.
Anat Rec 258: 119-127, 2000
13. Nakajima Y, Yamagishi T, Yoshimura K, Nomura M, Nakamura H. Antisense
oligodeoxynucleotide complementary to smooth muscle a-actin inhibits endothelial-mesenchymal
transformation during chick cardiogenesis. Dev. Dyn. 216:489-498, 1999
14. Yamagishi T, Nakajima Y, Miyazono K, Nakamura H. Bone morphogenetic
protein 2 acts synergistically with transforming growth factor b3 in endothelial-mesenchymal
transformation during chick heart development. J Cell Physiol. 180: 35-45,
1999
15. Yamagishi T, Nakajima Y, Nakamura H. Expression of TGFβ3 RNA during
chick embryogenesis: a possible important role in cardiovascular development.
Cell Tissue Res, 298: 85-93, 1999
16. Nakano M, Nakajima Y, Kudo S, Tsuchida Y, Nakamura H, Fukuda O. Successful
autotransplantation of microvessel fragments into the rat heart. Eur Surg
Res 31: 240-248, 1999
17. Nakajima Y, Miyazono K, Nakamura H. Immunolocalization of latent
transforming growth factor-βbinding protein-1 (LTBP1) during mouse development:
possible roles in epithelial and mesenchymal cytodifferentiation. Cell
Tissue Res 295: 257-267, 1999
18. Nakajima Y, Yamagishi Y, Nakamura H, Markwald RR, Krug EL. An autocrine
function for transforming growth factor (TGF)-β3 in the transformation
of atrioventricular canal endothelium into mesenchyme during chick heart
development. Dev. Biol. 194: 99-113, 1998
19. Nakano M, Nakajima Y, Kudo S, Tsuchida Y, Nakamura H, Fukuda O Effect of autotransplantation of microvessel fragments on experimental randam-pattern flaps in the rat. Eur. Surg. Res. 30: 149-160 1998