2017年

当教室の神吉将之先生の研究が第23回田邊賞を受賞いたしました。


Yamaguchi T, Gi M, Fujioka M, Doi K, Okuno T, Kakehashi A, Wanibuchi H. A carcinogenicity study of diphenylarsinic acid in F344 rats in drinking water for 104 weeks. J Toxicol Sci. 2017;42(4):475-483. doi: 10.2131/jts.42.475.PMID: 28717106

「第16回分子予防環境医学研究会」にて当教室の藤岡君が若手優秀発表賞を受賞しました。

Doi K, Fujioka M, Sokuza Y, Ohnishi M, Gi M, Takeshita M, Kumada K, Kakehashi A, Wanibuchi H. Chemopreventive Action by Ethanol-extracted Brazilian Green Propolis on Post-initiation Phase of Inflammation-associated Rat Colon Tumorigenesis. In Vivo. 2017 Mar-Apr;31(2):187-197.

Kakehashi A, Stefanov VE, Ishii N, Okuno T, Fujii H, Kawai K, Kawada N, Wanibuchi H. Proteome Characteristics of Non-Alcoholic Steatohepatitis Liver Tissue and Associated Hepatocellular Carcinomas. Int J Mol Sci. 2017 Feb 17;18(2). pii: E434. doi: 10.3390/ijms18020434.

Yamaguchi T, Gi M, Yamano S, Fujioka M, Tatsumi K, Kawachi S, Ishii N, Doi K, Kakehashi A, Wanibuchi H. A chronic toxicity study of diphenylarsinic acid in F344 rats in drinking water for 52 weeks. Exp Toxicol Pathol. 2017 Jan;69(1):1-7. doi: 10.1016/j.etp.2016.10.002. Epub 2016 Oct 28. PMID: 28029482

Ishii N, Gi M, Fujioka M, Yamano S, Okumura M, Kakehashi A, Wanibuchi H. Diphenylarsinic acid exerts promotion effects on hepatobiliary carcinogenesis in a rat medium-term multiorgan carcinogenicity bioassay. J Toxicol Pathol. 2017 Jan;30(1):39-45. doi: 10.1293/tox.2016-0049. Epub 2016 Oct 23.

2016年

「ラッシュ・プライズ2016(英国大手化粧品メーカーLush主催)」当教室の辰己さんが「若手研究者部門アジア」を受賞しました

Tachibana H, Gi M, Kato M, Yamano S, Fujioka M, Kakehashi A, Hirayama Y, Koyama Y, Tamada S, Nakatani T, Wanibuchi H.Carbonic anhydrase 2 is a novel invasion-associated factor in urinary bladder cancers.Cancer Sci. 2016 Dec 22. doi: 10.1111/cas.13143. [Epub ahead of print]

Yamaguchi T, Gi M, Yamano S, Fujioka M, Tatsumi K, Kawachi S, Ishii N, Doi K, Kakehashi A, Wanibuchi H. A chronic toxicity study of diphenylarsinic acid in F344 rats in drinking water for 52 weeks. Exp Toxicol Pathol. 2017 Jan;69(1):1-7. doi: 10.1016/j.etp.2016.10.002. Epub 2016 Oct 28.

Fujioka M, Gi M, Kawachi S, Tatsumi K, Ishii N, Doi K, Kakehashi A, Wanibuchi H. Examination of in vivo mutagenicity of sodium arsenite and dimethylarsinic acid in gpt delta rats. Journal of Environmental Sciences, 49:125-130. doi: 10.1016/j.jes.2016.07.005. Epub 2016 Jul 30.

Kakehashi A, Yoshida M, Tago Y, Ishii N, Okuno T, Gi M, Wanibuchi H. Pueraria mirifica Exerts Estrogenic Effects in the Mammary Gland and Uterus and Promotes Mammary Carcinogenesis in Donryu Rats. Toxins (Basel).8(11). pii: E275. 2016

Hirayama Y, Gi M, Yamano S, Tachibana H, Okuno T, Tamada S, Nakatani T, Wanibuchi H. Anti-PD-L1 treatment enhances antitumor effect of everolimus in a mouse model of renal cell carcinoma. Cancer Sci. doi: 10.1111/cas.13099. 2016

Kakehashi A, Ishii N, Fujioka M, Doi K, Gi M, Wanibuchi H. Ethanol-Extracted Brazilian Propolis Exerts Protective Effects on Tumorigenesis in Wistar Hannover Rats. PLoS One. 11(7):e0158654. doi: 10.1371/journal.pone.0158654.2016

Taya S, Kakehashi A, Wongpoomchai R, Gi M, Ishii N, Wanibuchi H. Preventive Effects of Spirogyra neglecta and a Polysaccharide Extract against Dextran Sodium Sulfate Induced Colitis in Mice. Asian Pac J Cancer Prev. 17(4):2235-45.2016

Kanki M, Gi M, Fujioka M, Wanibuchi H. Detection of non-genotoxic hepatocarcinogens and prediction of their mechanism of action in rats using gene marker sets. J Toxicol Sci, 281-292, 2016.

Kakehashi A, Ishii N, Sugihara E, Gi M, Saya H, Wanibuchi H. CD44v9 is a potential biomarker of tumor initiating cells predicting survival outcome in HCV-positive patients with resected HCC. Cancer Sci, 107, 609-618, 2016.

Yamano S, Gi M, Tago Y, Doi K, Okada S, Hirayama Y, Tachibana H, Ishii N, Fujioka M, Tatsumi K, Wanibuchi H. Role of deltaNp63 CD44v cells in the development of N-nitroso-tris-chloroethylurea-induced peripheral-type mouse lung squamous cell carcinomas. Cancer Sci, 107, 123-132, 2016.

「第32回日本毒性病理学会総会及び学術集会」にて特任助教の藤岡くんが年会長賞優秀賞を受賞しました。


2015年

Gi M, Fujioka M, Yamano S, Shimomura E, Kanki M, Kawachi S, Tachibana H, Tatsumi K, Fang H, Ishii N, Kakehashi A, Wanibuchi H
Modifying effects of 1,2-dichloropropane on N-nitrosobis(2-oxopropyl)amine-induced cholangiocarcinogenesis in male Syrian hamsters.The Journal of toxicological sciences 40(5) 647-656 2015年

Shoji Fukushima; Min Gi; Anna Kakehashi; Hideki Wanibuchi; Michiharu Matsumoto
Qualitative and quantitative approaches in the dose-response assessment of genotoxic carcinogens.Mutagenesis. 2015 , DOI: 10.1093/mutage/gev049, PMID: 26152227

藤岡正喜, 鰐渕英機
身の回りの化学物質のリスク評価とリスク管理 食品中の汚染物質のリスク評価とリスク管理 Foods & Food Ingred J Jpn 220(3) 217-222 2015年8月

Xie XL, Gi M, Fujioka M, Doi K, Yamano S, Tachibana H, Fang H, Kakehashi A, Wanibuchi H.
Ethanol-extracted propolis enhances BBN-initiated urinary bladder carcinogenesis via non-mutagenic mechanisms in rats.Food Chem Toxicol. 2015 Jun 23;83:193-200. doi: 10.1016/j.fct.2015.06.007. [Epub ahead of print]

Kakehashi A, Hagiwara A, Imai N, Wei M, Fukushima S, Wanibuchi H.
Induction of cell proliferation in the rat liver by the short-term administration of ethyl tertiary-butyl ether.J Toxicol Pathol. 2015 Jan;28(1):27-32. doi: 10.1293/tox.2014-0056. Epub 2015 Jan 6.

Fukunaga S, Kakehashi A, Sumida K, Kushida M, Asano H, Gi M, Wanibuchi H.
Integrative analyses of miRNA and proteomics identify potential biological pathways associated with onset of pulmonary fibrosis in the bleomycin rat model.Toxicol Appl Pharmacol. 2015 Aug 1;286(3):188-97. doi: 10.1016/j.taap.2015.04.014. Epub 2015 Apr 28.

Yuko Kuwae; Anna Kakehashi; Kenichi Wakasa; Min Wei; Shotaro Yamano; Naomi Ishii; Masahiko Ohsawa; Hideki Wanibuchi
Paraneoplastic Ma Antigen-Like 1 as a Potential Prognostic Biomarker in Human Pancreatic Ductal Adenocarcinoma.Pancreas. 2015 , DOI: 10.1097/MPA.0000000000000220, PMID: 25251443

Min Wei, Masaki Fujioka, Shotaro Yamano, Eri Shimomura, Naomi Ishii, Anna Kakehashi, Masanori Takeshita, Hideki Wanibuchi
Determination of Hepatotoxicity and Its Underlying Metabolic Basis of 1,2-dichloropropane in Male Syrian Hamsters and B6C3F1 Mice. Toxicological sciences, 2015; doi:10.1093/toxsci/kfv045

「第31回日本毒性病理学会総会及び学術集会」にて修士課程二年の三島胡桃さんがThe IFSTP Trainee Awardを受賞しました。


2014年

「平成26年度がん若手研究者ワークショップ」にて山野助教が優秀演者賞を受賞しました。


Izumi Y, Yamaguchi T, Yamazaki T, Yamashita N, Nakamura Y, Shiota M, Tanaka M, Sano S, Osada-Oka M, Shimada K, Wanibuchi H, Miura K, Yoshiyama M, Iwao H.
Percutaneous Carbon Dioxide Treatment using a Gas Mist Generator Enhances the Collateral Blood Flow in the Ischemic Hindlimb.J Atheroscler Thromb. 2014 Aug 15. [Epub ahead of print]

藤岡正喜, 魏民, 鰐渕英機
職業・環境発がん:メカニズムと病理 ヒ素中毒・発がんの機序と現状, 病理と臨床 32(6) 638-642 2014年6月

Wakui S, Mutou T, Takahashi H, Ikegami M, Wanibuchi H, Fukushima S.
Vascular endothelial growth factor mRNA levels as a biomarker for short-term N-butyl-N-(4-hydroxybutyl) nitrosamine-induced rat bladder carcinogenesis bioassay.J Appl Toxicol. 2014 May 28. doi: 10.1002/jat.3021. [Epub ahead of print]

Tago Y, Fujii T, Wada J, Kato M, Wei M, Wanibuchi H, Kitano M.
Genotoxicity and subacute toxicity studies of a new astaxanthin-containing Phaffia rhodozyma extract.J Toxicol Sci. 2014 Jun;39(3):373-82.

Yamada T, Wei M, Toyoda T, Yamano S, Wanibuchi H.
Inhibitory effect of raphanobrassica on Helicobacter pylori-induced gastritis in Mongolian gerbils.Food Chem Toxicol. 2014 Aug;70:107-13. doi: 10.1016/j.fct.2014.04.037. Epub 2014 May 13.

Tanaka M, Mun S, Harada A, Ohkawa Y, Inagaki A, Sano S, Takahashi K, Izumi Y, Osada-Oka M, Wanibuchi H, Yamagata M, Yukimura T, Miura K, Shiota M, Iwao H.
Hsc70 contributes to cancer cell survival by preventing Rab1A degradation under stress conditions.PLoS One. 2014 May 6;9(5):e96785. doi: 10.1371/journal.pone.0096785. eCollection 2014.

Takada J, Hoshi M, Oebisu N, Ieguchi M, Kakehashi A, Wanibuchi H, Nakamura H.
A comparative study of clinicopathological features between simple bone cysts of the calcaneus and the long bone.Foot Ankle Int. 2014 Apr;35(4):374-82. doi: 10.1177/1071100713519600. Epub 2014 Jan 9.

Sano S, Izumi Y, Yamaguchi T, Yamazaki T, Tanaka M, Shiota M, Osada-Oka M, Nakamura Y, Wei M, Wanibuchi H, Iwao H, Yoshiyama M.
Lipid synthesis is promoted by hypoxic adipocyte-derived exosomes in 3T3-L1 cells.Biochem Biophys Res Commun. 2014 Mar 7;445(2):327-33. doi: 10.1016/j.bbrc.2014.01.183. Epub 2014 Feb 7.

藤岡正喜, 山野荘太郎, 魏 民, 鰐渕英機
免疫組織染色の定量法, 細胞工学 33(3) 316-322 2014年2月

Inoue T, Nakayama Y, Li Y, Matsumori H, Takahashi H, Kojima H, Wanibuchi H, Katoh M, Oshimura M.
SIRT2 knockdown increases basal autophagy and prevents postslippage death by abnormally prolonging the mitotic arrest that is induced by microtubule inhibitors.FEBS J. 2014 Jun;281(11):2623-37. doi: 10.1111/febs.12810. Epub 2014 Apr 30.

2013年

Kato M, Wei M, Yamano S, Fujioka M, Kakehashi A, Wanibuchi H.
Evaluation of the modifying effect of inhalation of mainstream cigarette smoke on mouse bladder carcinogenesis.J Toxicol Pathol. 2013 Dec;26(4):447-51. doi: 10.1293/tox.2013-0039. Epub 2013 Dec 26.

Hanada S, Kakehashi A, Nishiyama N, Wei M, Yamano S, Chung K, Komatsu H, Inoue H, Suehiro S, Wanibuchi H.
Myristoylated alanine-rich C-kinase substrate as a prognostic biomarker in human primary lung squamous cell carcinoma.Cancer Biomark. 2013;13(4):289-98. doi: 10.3233/CBM-130354.

Kakehashi A, Wei M, Fukushima S, Wanibuchi H.
Oxidative stress in the carcinogenicity of chemical carcinogens.Cancers (Basel). 2013 Oct 28;5(4):1332-54. doi: 10.3390/cancers5041332.

Takahashi K, Tanaka M, Inagaki A, Wanibuchi H, Izumi Y, Miura K, Nagayama K, Shiota M, Iwao H.
Establishment of a 5-fluorouracil-resistant triple-negative breast cancer cell line.Int J Oncol. 2013 Dec;43(6):1985-91. doi: 10.3892/ijo.2013.2135. Epub 2013 Oct 10.

Tago Y, Yamano S, Wei M, Kakehashi A, Kitano M, Fujioka M, Ishii N, Wanibuchi H.
Novel medium-term carcinogenesis model for lung squamous cell carcinoma induced by N-nitroso-tris-chloroethylurea in mice.Cancer Sci. 2013 Dec;104(12):1560-6. doi: 10.1111/cas.12289. Epub 2013 Nov 24.

Kakehashi A, Hagiwara A, Imai N, Nagano K, Nishimaki F, Banton M, Wei M, Fukushima S, Wanibuchi H.
Mode of action of ethyl tertiary-butyl ether hepatotumorigenicity in the rat: evidence for a role of oxidative stress via activation of CAR, PXR and PPAR signaling pathways.Toxicol Appl Pharmacol. 2013 Dec 1;273(2):390-400. doi: 10.1016/j.taap.2013.09.016. Epub 2013 Sep 30.

Wei M, Yamada T, Yamano S, Kato M, Kakehashi A, Fujioka M, Tago Y, Kitano M, Wanibuchi H.
Diphenylarsinic acid, a chemical warfare-related neurotoxicant, promotes liver carcinogenesis via activation of aryl hydrocarbon receptor signaling and consequent induction of oxidative DNA damage in rats.Toxicol Appl Pharmacol. 2013 Nov 15;273(1):1-9. doi: 10.1016/j.taap.2013.08.022. Epub 2013 Aug 30.

Komatsu H, Kakehashi A, Nishiyama N, Izumi N, Mizuguchi S, Yamano S, Inoue H, Hanada S, Chung K, Wei M, Suehiro S, Wanibuchi H.
Complexin-2 (CPLX2) as a potential prognostic biomarker in human lung high grade neuroendocrine tumors.Cancer Biomark. 2013;13(3):171-80. doi: 10.3233/CBM-130336

Hanada S, Nishiyama N, Mizuguchi S, Yamano S, Kakehashi A, Wei M, Inoue H, Komatsu H, Chung K, Suehiro S, Wanibuchi H.
Clinicopathological significance of combined analysis of cytokeratin19 expression and preoperative serum CYFRA21-1 levels in human lung squamous cell carcinoma.Osaka City Med J. 2013 Jun;59(1):35-44.

Xie XL, Kakehashi A, Wei M, Yamano S, Takeshita M, Yunoki T, Wanibuchi H.
L-Leucine and L-isoleucine enhance growth of BBN-induced urothelial tumors in the rat bladder by modulating expression of amino acid transporters and tumorigenesis-associated genes.Food Chem Toxicol. 2013 Sep;59:137-44. doi: 10.1016/j.fct.2013.05.044. Epub 2013 Jun 5.

Yabushita S, Fukamachi K, Kikuchi F, Ozaki M, Miyata K, Sukata T, Deguchi Y, Tanaka H, Kakehashi A, Kawamura S, Uwagawa S, Wanibuchi H, Suzui M, Alexander DB, Tsuda H.
Twenty-one proteins up-regulated in human H-ras oncogene transgenic rat pancreas cancers are up-regulated in human pancreas cancer.Pancreas. 2013 Aug;42(6):1034-9. doi: 10.1097/MPA.0b013e3182883624.

鰐渕英機, 魏 民, 山野荘太郎, 藤岡正喜, 加藤実
目で診る膀胱癌 癌組織像を診る ビルハルツ住血吸虫症と膀胱癌:泌尿器外科 25(6) 1314-1318 2012年6月

Hoshi H, Sawada T, Uchida M, Iijima H, Kimura K, Hirakawa K, Wanibuchi H.
MUC5AC protects pancreatic cancer cells from TRAIL-induced death pathways. Int J Oncol, 42, 887-893, doi: 10.3892/ijo.2013.1760. 2013.

Toba S, Tamura Y, Kumamoto K, Yamada M, Takao K, Hattori S, Miyakawa T,T Kataoka Y, Azuma M, Hayasaka K, Amamoto M, Tominaga K, Wynshaw-Boris A, Wanibuchi H, Oka Y, Sato M, Kato M, Hirotsune S.
Post-natal treatment by a blood-b ain-barrier permeable calpain inhibitor, SNJ1945 rescued defective function in lissencephaly. Sci Rep, 3, 1224, doi: 10.1038/srep01224. 2013.

2012年

Nakatani S, Ishimura E, Mori K, Fukumoto S, Yamano S, Wei M, Emoto M, Wanibuchi H, Inaba M.
Nephronectin expression in glomeruli of renal biopsy specimens from various kidney diseases: nephronectin is expressed in the mesangial matrix expansion of diabetic nephropathy.Nephron Clin Pract. 2012;122(3-4):114-21. doi: 10.1159/000350816. Epub 2013 May 8. Nakatani, S., Wei, M., Ishimura, E., Kakehashi, A., Mori, K., Nishizawa, Y., Inaba, M. and Wanibuchi, H.
Proteome analysis of laser microdissected glomeruli from formalin-fixed paraffin-embedded kidneys of autopsies of diabetic patients: nephronectin is associated with the development of diabetic glomerulosclerosis. Nephrol Dial Transpl, 27, 1889-1897, 2012.

Kakehashi, A., Tago, Y., Yoshida, M., Suokuza, Y., Wei, M., Fukushima, S. and Waibuchi, H.
Hormonally active doses of isoflavone aglycones promote mammary and endometrial carcinogenesis and alter the molecular tumor environment in donryu rats. Toxicol Sci, 126, 39-51, 2012.

Kato M, Wei M, Yamano S, Kakehashi A, Tamada S, Nakatani T, Wanibuchi H.
DDX39 acts as a suppressor of invasion for bladder cancer. Cancer Sci, DOI: 10.1111/j.1349-7006.2012.

Wei M, Kakehashi A, Yamano S, Tamano S, Shirai T, Wanibuchi H, Fukushima S.
Lack of Hepatocarcinogenicity of Combinations of Low Doses of 2-amino-3, 8-dimethylimidazo[4,5- f ]quinoxaline and Diethylnitrosamine in Rats: Indication for the Existence of a Threshold for Genotoxic Carcinogens. J Toxicol Pathol, 25, 209-214, 2012.

Xie XL, Wei M, Yunoki T, Kakehashi A, Yamano S, Kato M, Wanibuchi H.
Long-term treatment with l-isoleucine or l-leucine in AIN-93G diet has promoting effects on rat bladder carcinogenesis. Food Chem Toxicol, 50, 3934-3940, 2012. doi: 10.1016/j.fct.2012.07.063.

Xie XL, Wei M, Kakehashi A, Yamano S, Okabe K, Tajiri M, Wanibuchi H.
Dammar resin, a non-mutagen, inducts oxidative stress and metabolic enzymes in the liver of gpt delta transgenic mouse which is different from a mutagen, 2-amino-3-methylimidazo[4,5-f]quinoline. Mutat Res, 748, 29-35, 2012.

Punvittayagul C, Pompimon W, Wanibuchi H, Fukushima S, Wongpoomchai R.
Effects of pinocembrin on the initiation and promotion stages of rat hepatocarcinogenesis. Asian Pac J Cancer Prev, 13, 2257-2261, 2012.

Chung K, Nishiyama N, Wanibuchi H, Yamano S, Hanada S, Wei M, Suehiro S, Kakehashi A.
AGR2 as a potential biomarker of human lung adenocarcinoma. Osaka City Med J, 58, 13-24, 2012.

鰐渕英機、山野荘太郎、魏 民
第5回肺がんモデル.細胞工学, 31, 1384-1389, 2012.

2011年

Wei M, Wanibuchi H, Nakae D, Tsuda H, Takahashi H, Hirose M, Totsuka M, Tatematsu M, Fukushima S.
Low-dose carcinogenicity of 2-amino-3-methylimidazo[4,5- f ]quinoline in rats: Evidence for the existence of no-effect levels and a mechanism involving p21Cip/WAF1. Cancer Sci., 102, 88-94, 2011 .

Kakehashi, A., Ishii, N., Shibata, T., Wei, M., Okazaki, E., Tachibana, T., Fukushima, S. and Wanibuchi, H.
Mitochondrial prohibitins and septin 9 are implicated in the onset of rat hepatocarcinogenesis. Toxicol. Sci., 119, 61-72, 2011.

Chusiri, Y., Wongpoomchai, R., Kakehashi, A., Wei, M., Wanibuchi, H., Vinitketkumnuan, U. and Fukushima, S.
Non-genotoxic mode of action and possible threshold for hepatocarcinogenicity of Kojic acid in F344 rats. Food Chem Toxicol. 49(2): 471-6, 2011.

Hoshi, H., Sawada, T., Uchida,M., Saito, H., Iijima,H., Toda-Agetsuma,M., Wada,T., Yamazoe, S., Tanaka, H., Kimura, K., Kakehashi, A., Wei, M., Hirakawa,K., Wanibuchi, H.
Tumor-associated MUC5AC stimulates in vivo tumorigenicity of human pancreatic cancer. International journal of oncology 38(3): 619-627, 2011.

Ishii, N., Wei, M., Kakehashi, A., Doi, K., Yamano, S., Inaba, M. and Wanibuchi, H.
Enhanced urinary bladder, liver and colon carcinogenesis in Zucker diabetic fatty rats in a mulri-organ carcinogenesis: Evidence for mechanisms involving activation of PI3K signaling and impairment of p53 on urinary bladder carcinogenesis. J Toxicol Pathol.24: 1-12, 2011.

2010年

Doi, K., Sakai , K., Tanaka, R., Toma, K., Yamaguchi, T., Wei, M., Fukushima , S. and Wanibuchi, H.
Chemopreventive effects of 13alpha,14alpha-epoxy-3beta-methoxyserratan-21beta-ol (PJJ-34), a serratane-type triterpenoid, in a rat multi-organ carcinogenesis bioassay. Cancer Lett., 289, 161-169, 2010.

Kakehashi, A., Kato, A., Inoue, M., Ishii, N., Okazaki, E., Wei, M., Tachibana, T. and Wanibuchi, H.
Cytokeratin 8/18 as a new marker of mouse liver preneoplastic lesions. Toxicol.Appl.Pharmacol., 242, 47-55, 2009.

Suzuki, S., Arnold, L. L., Pennington, K. L., Kakiuchi-Kiyota, S., Wei, M., Wanibuchi, H. and Cohen, S. M.
Effects of pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, on the urine and urothelium of the rat. Toxicol Sci.,113, 349-357, 2010.

鰐渕英機、魏 民、石井真美、福島昭治
目で診る膀胱癌-癌組織像をみる.第 1 回膀胱癌の組織像.膀胱癌 FRONTIER, 03, 2-7, 2010.

鰐渕英機
ピロリ菌誘発胃炎におけるラファノブラシカの修飾作用.日本がん予防研究会 , News Letter. No.64, p.4-5, June, 2010.

Takahashi, Y., Hara, Y., Imanaka, M., Wanibuchi, H., Tanaka, K., Ishikawa, T., Mori, S. and Fukusato, T.
No inhibitory effects of ( - )-epigallocatechin gallate and lycopene on spontaneous hepatotumorigenesis in C3H/HeN mice. Fukushima J. Med. Sci., 56, 17-27, 2010.

Fukushima, S., Wei, M., Kakehashi, A. and Wanibuchi, H.
Thresholds for genotoxic carcinogens: Evidence from mechanism-based carcinogenicity studies. Cancer Risk Assessment, 8, 207-221, 2010.

Tago, Y., Wei, M., Ishii, N., Kakehashi, A. and Wanibuchi, H.
Evaluation of the subchronic toxicity of dietary administered Equisetum arvense in F344 rats. J Toxicol. Pathol., 23, 245-251, 2010.

2009年

Doi, K., Wei, M., Kitano, M., Uematsu, N., Inoue, M. and Wanibuchi, H.
Enhancement of preneoplastic lesion yield by chio s mastic Ggm i n a rat liver medium-term carcinogenesis bioassay. Toxicol.Appl.Pharmacol., 234, 135-142, 2009.

八代正和、豊川貴弘、鰐渕英機、小野田尚佳、羽室雅夫、渡辺俊雄、斯波政次、六車一哉、富永和作、山下好人、澤田鉄二、大平雅一、平川弘聖、上田真喜子
残胃癌.綜合臨牀 , 第 58 巻第 2 号, 370-377 , 2009.

中村卓也、松井 宏、川又誠也、中野和彦、片山貴子、日野雅之、鰐渕英機、荒波一司、山田 隆、辻 幸一
血液中金属元素の全反射蛍光 X 腺分析. X 腺分析の進歩 , 40, 249-257, 2009.

Kushida, M., Wanibuchi, H., Wei, M., Kakehashi, A., Ozaki, K., Sukata, T., Miyata, K., Ogata, K., Uwagawa, S. and Fukushima, S.
Ethanol dose not promote MeIQx-initiated rat colon carcinogenesis based on evidence from analysis of a colon cancer surrogate marker. J Toxicol.Pathol., 22, 65-70, 2009.

Tanaka-Okamoto, M., Hori, K., Ishizaki, H., Hosoi, A., Itoh, Y., Wei, M., Wanibuchi, H., Mizogchi, A., Nakamura, H. and Miyoshi, J.
Increased susceptibility to spontaneous lung cancer in mice lacking LIM-domain only 7. Cancer Sci, 100, 608-616, 2009.

Fukushima, S., Kakehashi, A., Wei, M. and Wanibuchi, H.: Existence of a threshold for the genotoxic carcinogens
Evidence from mechanism-based carcinogenicity studies. Genes and Environment, 31, 33-36, 2009.

Kakehashi, A., Inoue, M., Wei, M., Fukushima, S. and Wanibuchi, H.
Cytokeratin 8/18 overexpression and complex formation as an indicator of GST-P positive foci transformation into hepatocellular carcinomas. Toxicol.Appl.Pharmacol., 238, 71-79, 2009.

Romanenko, A., Kakehashi, A., Morimura,K., Wanibuchi, H., Wei, M., Vozianov, A. and Fukushima S.
Urinary bladder carcinogenesis induced by chronic exposure to persistent low-dose ionizing radiation after Chernobyl accident. Carcinogenesis, 30, 1821-1831, 2009.

Wei, M., Hamoud, A.S., Yamaguchi, T., Kakehashi, A., Morimura, K., Doi, K., Kushida, M., Kitano, M., Wanibuchi, H. and Fukushima, S.
Patassium bromated enhances N-Ethyl-N-Hydroxyethylnitrosamine-Induced kidney carcinogenesis only at high dose in wistar rats: Indication of the existence of an enhancement threshold. Toxicol Pathol., 37, 983-991, 2009.

2008年

鰐渕英機、魏 民、梯アンナ、福島昭治
尿路上皮癌の組織分類:新 WHO 分類との対比.病理と臨床.特集:尿路系腫瘍をめぐる諸問題, 2, Vol.26, 124-129, 2008.

Yamaguchi, T., Wei, M., Hagihara, N., Omori, M., Wanibuchi, H., and Fukushima, S.
Lack of mutagenic and toxic effects of low dose potassium bromate on kidneys in the Big Blue rat. Mutat.Res., 652, 1-11, 2008.

Salim, E. I., Morimura, K., Menesi A., El-Lity, M., Fukushima S. and Wanibuchi H.
Elevated oxidative stress and DNA damage and repair levels in urinary bladder carcinomas associated with schistosomiasis. Int J Cancer. 123, 601-608, 2008.

Yamaguchi, C., Wanibuchi, H.,Kakehashi, A., Tanaka, R. and Fukushima , S.
Chemopreventive effects of a serratane-type triterpenoid, 3 α -methoxyserrat-14-en-21β-ol (PJ-1), against rat lung carcinogenesis. Food Chem Toxicol., 46, 1882-1888, 2008.

Murai, T., Mori, S., Kang, J. S., Morimura, K., Wanibuchi, H., Totsuka, Y. and Fukushima , S.
Evidence of a threshold-effect for 2-amino-3,8-dimethylimidazo[4, 5-f]quinoxaline liver carcinogenicity in F344/DuCrj Rats. Toxicol.Pathol., 36, 472-477, 2008.

鰐渕英機
健康食品の安全性を考える-マスティックの発がん性評価-.日本がん予防学会 , News Letter, 56, 3-4, 2008.

福島昭治、魏 民、梯アンナ、鰐渕英機
発がん物質にも閾値が存在する. Mycotoxins, 58, 119-128, 2008.

福島昭治、魏 民、梯アンナ、鰐渕英機
環境化学発がん物質とその閾値 食品などに含まれる発がん物質を例として.クリーンテクノロジー , 18, 20-25, 2008.

Kang, J.S., Wanibuchi, H., Morimura, K., Wongpoomchai, R., Chusiri, Y., Gonzalez, F.J. and Fukushima, S.
Role of CYP2E1 in thioacetamide-induced mouce hepatotoxicity. Toxicol.Appl.Pharmacol., 228, 295-300, 2008.

八代正和、鰐渕英機、町田浩久、前田 清、高田佳江、松田常美、仲田文造、田代敬彦、中村 肇、天道正成、西原承浩、西野裕二、平川弘聖、上田真喜子
大腸癌.綜合臨牀 ,57,2396-2404,2008.

福島昭治、梯 アンナ、魏 民、鰐渕英機
食品などに含まれる発がん物質に閾値が存在するのか.食衛誌 , 49, J314-J318, 2008.

Hayashi, S., Fujii, E., Kato, A., Kimura, K., Mizoguchi, K., Suzuki, M., Sugimoto, T., Takanashi, H., Itoh, Z., Omura, S. and Wanibuchi, H.
Characterization of multinuclear hepatocytes induced in rats by mitemcinal (GM-611), an erythromycin derivative. Toxicol.Pathol., 36, 858-865, 2008.

Nakae, D., Wanibuchi, H., Konishi, Y. and Fukushima, S.
Possible involvement of adaptation mechanisms in the achievement of an ineffective dose range for the carcinogenicity of genotoxic carcinogens. Genes and Environment, 30, 125-131, 2008.

2007年

Iwai, S., Murai, T., Makino, S., Wei, M., Morimura, K., Mori, S., Hagihara, A., Seki, S. and Fukushima, S.
High sensitivity of fatty liver Shionogi (FLS) mice to diethylnitrosamine hepatocarcinogenesis: comparison to C3H and C57 mice. Cancer Lett., 246, 115-121, 2007.

Kang, J. S., Wanibuchi, H., Murai, T., Morimura, K., Kinoshita, A. and Fukushima, S.
Analysis of gene expression in different stages of MeIQx-induced rat hepatocarcinogenesis. Oncol Rep, 17, 747-752, 2007.

Anetor, J. I., Wanibuchi, H. and Fukushima, S.
Arsenic exposure and its health effects and risk of cancer in developing countries: micronutrients as host defence. Asian Pac J Cancer Prev, 8, 13-23, 2007.

福島昭治、鰐渕英機、魏 民
食品に含まれる発がん物質には閾値がある. ILSI, 89, 37-43, 2007.

Kinoshita, A., Wanibuchi, H., Wei, M., Yunoki, T. and Fukushima, S.
Elevation of 8-hydroxydeoxyguanosine and cell proliferation via generation of oxidative stress by organic arsenicals contributes to their carcinogenicity in the rat liver and bladder. Toxicol.Appl.Pharmacol., 221, 295-305, 2007.

Fukushima, S., Wanibuchi, H., Wei, M., Morimura, K. and Kinoshita, A.
Low dose carcinogenicity of genotoxic carcinogens. FFI Journal, 212, 455-459, 2007.

鰐渕英機、魏 民、梯アンナ、福島昭治
慢性ヒ素汚染 -がんと烏脚病- .病理と臨床・別冊 , 25, 780-785, 2007.

福島昭治、鰐渕英機、魏 民
発がん物質には閾値が存在する.病理と臨床 , 25, 751-756, 2007.

Kinoshita, A., Wanibuchi, H., Morimura, K., Wei, M., Nakae, D., Arai, T., Minowa, O., Noda, T., Nishimura, S. and Fukushima, S.
Carcinogenicity of dimethylarsinic acid in Ogg1-deficient mice. Cancer Sci., 98, 803-814, 2007.

Kang, J. S., Wanibuchi, H., Morimura, K., Gonzalez, F. J., and Fukushima, S.
Role of CYP2E1 in diethylnitrosamine-induced hepatocarcinogenesis in vivo . Cancer Res., 67:(23), 11141-11146, 2007.

Kang, J. S., Wanibuchi, H., Salim, E. I., Kinoshita, A., and Fukushima, S.
Evaluation of the toxicity of mastic gum with 13 weeks dietary administration to F344 rats. Food Chem.Toxicol., 45(3), 494-501, 2007.

Doi, K., Hagihara, A., Wei, M., Yunoki, T., Fukushima , S. and Wanibuchi, H.
Altered gene expression in rat colonic adenocarcinomas induced in an azoxymethane plus 2-amino-1-methyI-6-phenylimidazo[4,5-b]-pyridine initiation-promotion model. Oncology, 73, 252-260, 2007.

Kato, K., Mizoi, M., An, Y., Nakano, M., Wanibuchi, H., Endo, G., Endo, Y., Hoshino, M., Okada, S. and Yamanaka, K.
Oral administration of diphenylarsinic acid, a degradation product of chemical warfare agents, induces oxidative and nitrosative stress in cerebellar purkinje cells. Life Sci., 81, 1518-1525, 2007.

土井賢一郎、田中雅彰、金 光華、渡辺恭良、福島昭治、鰐渕英機
疲労が生体に及ぼす影響、ならびに胃発がんを助長する可能性について . 日本疲労学会誌 . 第 2 巻第 2 号 , 8-16, 2007.

2006年

Wei, M., Hori, T., Wanibuchi, H., Morimura, K., Kang, J.S., Puatanachokchai, R. and Fukushima, S.
Exisence of no-observed effect levels for 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline on hepatic preneoplastic lesion development in BN rats. Cancer Letters, 231, 304-308, 2006.

Romanenko. A., Morimura, K., Kinoshita, A., Wanibuchi, H., Vozianov, A. and Fukushima, S.
Aberrant expression of E-cadherin and -catenin in association with transforming growth factor- 1 in urinary bladder lesions in humans after the Chernobyl accident. Cancer Sci., 97, 45-50, 2006.

Shen, J., Wanibuchi, H., Waalkes, M. P., Salim, E. I. Kinoshita, A., Yoshida, K., Endo, G. and Fukushima, S.
A comparative study of the sub-chronic toxic effects of three organic arsenical compounds on the urothelium in F344 rats; gender-based differences in response. Toxicol. Appl. Pharmacol., 210, 171-180, 2006.

福島昭治
発がん物質の閾値.JAFAN日本食品添加物ニュース,25, 1-8, 2006.

Kang, J. S., Morimura, K., Toda, C., Wanibuchi, H., Wei, M., Kojima, N. and Fukushima, S.
Testicular toxicity of DEHP, but not DEHA, is elevated under conditions of thioacetamide-induced liver damage. Reproductive Toxicology, 21, 253-259, 2006.

Romanenko, A. M., Kinoshita, A., Wanibuchi, H., Wei, M., Zaparin, W. K., Vinnichenko, W. I., Vozianov, A. F. and Fukushima, S.
Involvement of ubiquitination and sumoylation in bladder lesions induced by persistent long-term low dose ionizing raditation in humans. The Journal of Urology, 175, 739-743, 2006.

Hagihara, A., Wanibuchi, H., Puatanachokchai, R., Kang, J. S., Miyazi, N., Seki, S. and Fukusima, S.
Difference in sensitivity of F344 rats from different breeders to phenobarbital hepatpcarcinogenicity. J Toxicol Pathol, 19, 29-36, 2006.

鰐渕英機、福島昭治
第1章組織診編. 21.膀胱, 病理と臨床【臨時増刊号】.vol.24, 144-152, 文光堂, 2006.

Kang, J. S., Waniuchi, H., Morimura, K., Totsuka, Y., Yoshimura, I. and Fukushima, S.
Existence of a no effect level for MelQx hepatocarcinogenicity on background of thioacetamide-induced liver damage in rats. Cancer Sci, 97, 453-458, 2006.

Kushida, M., Aiso, S., Morimura, K., Wei, M., Wanibuchi, H., Nagano, K. and Fukushima, S.
Absence of β-Catenin Alteration in Hepatic Tumors Induced by p-Nitroanisole in Crj:BDF1 Mice. Toxicologic Pathology, 34, 237-242, 2006.

Wanibuchi, H., Wei, M., Karim, M. R., Morimura, K., Doi, K., Kinoshita, A. and Fukushima, S.
Existence of no hepatocarcinogenic effect levels of 2-amino-3, 8-dimethylimidazo[4, 5-f]quinoxaline with or without coadministration with ethanol. Toxicologic Pathology, 34, 232-236, 2006.

Waddell, W. J., Fukushima, S. and Williams, G. M.
Concordance of thresholds for carcinogenicity of N-nitrosodierhylamine. Arch Toxicol, 80, 305-309, 2006.

Uda, N., Kashimto, N., Sumioka, I., Kyo, E., Sumi, S. and Fukushima, S.
Aged garlic extract inhibits development of putative preneoplastic lesions in rat hepatocarcinogenesis. American Society for Nutrition, 855S-860S, 2006.

福島昭治,鰐渕英機,魏 民,森村圭一朗
ハイリスク膀胱がんの自然史. 泌尿紀要, 52, 451-455, 2006.

Kitano, M., Chen, Tian-Xin., Morimura, K., Wei, M., Hidaka, T., Hosoe, K. and Fukushima, S.
Biphasic increase of epithelial DNA synthesis in the urinary bladder of rats treated with a tumor promoter, sodium L-ascorbate. J. Toxicol. Pathol, 19, 53-56, 2006.

Kitano, M., Wada, J., Ariki, Y., Kato, M., Wanibuchi, H., Morimura, K., Hidaka, T., Hosoe, T. and Fukushima, S.
Possible tumor development from double positive foci for TGF-alpha and GST-P observed in early stages on rat hepatocarcinogenasis. Cancer Sci, 97, 478-483, 2006.

Mori, S., Murai, T., Wanibuchi, H., Hagihara, A., Puatanachokchai, P. and Fukushima, S.
Susceptibility of four F1 hybrids of male rats to the promoting effects of sodium L-ascorbate in two-stage urinary bladder carcinogenesis. J Toxicol Pathol. 19, 87-91,2006.

Puatanachokchai, R., Morimura, K., Wanibuchi, H., Oka, M., Kinoshita, A., Fukui, M., Yamaguchi, S., Funae, Y. and Fukushima, S.
Alpha-benzene hexachloride exerts hormesis in preneoplastic lesion formation of rat hepatocarcinogesis with the possible role for hepatic detoxifying enzymes. Cancer Lett., 240, 102-113, 2006.

Nakajima, Y., Endo, Y., Inoue, Y., Yamanaka, K., Kato, K., Wanibuchi, H. and Endo, G.
Ingestion of Hijiki seaweed and risk of arsenic poising+. Appl Organometal Chem., 20, 557-564, 2006.

Kinoshita, A., Wanibuchi, H., Wei, M. and Fukushima, S.
Hormesis in carcinogenicity of non-genotoxic carcinogens. J.Toxicol.Pathol., 19, 111-122, 2006.

Romanenko, A. M., Morimura, K., Kinoshita, A., Wanibuchi, H., Takahashi, S., Zaparin, W. K., Vinnichenko, W. K., Vozianov, A. F. and Fukushima S.
Upregulation of fibroblast growth factor receptor 3 and epidermal growth factor receptors, in association with Raf-1, in urothelial dysplasia and carcinoma in situ after the Chernobyl accident. Cancer Sci. 97, 1168-1174, 2006.

鰐渕英機
天然由来物質による肝発がん予防. News Letter. 50, 5, 2006.

福島昭治
化学発がんのホルミシス. News Letter. 49, 3, 2006.

2005年

Wei, M., Morimura, K., Wanibuchi, H., Shen, J., Salim, E. I., Moku, M., Hakoi, K. and Fukushima, S.
JTE-522, a selective cyclooxygenase-2 inhibitor, inhibits induction but not growth and invasion of 1,2-dimethylhydrazine-induced tubular adenocarcinomas of colon in rats. Int. J. Cancer, 113, 354-358, 2005.

福島昭治、鰐渕英機、森村圭一朗、魏 民
遺伝毒性発がん物質の閾値:頂上征服への一途上.化学生物総合管理,1, 10-17, 2005.

Kuroda, K., Yoshida, K., Yoshimura, M., Endo, Y., Wanibuchi, H., Fukushima, S. and Endo, G.
Genotoxicity of dimethylarsinous acid: high induction of tetraploids. Appl. Organometal. Chem., 19, 221-225, 2005.

福島昭治
化学発癌.茶論「LWWC設立一周年記念シンポジウム」,1, 53-93, 2005.

475. 福島昭治
「大阪市立大学看護学雑誌」の発刊にあたって.大阪市立大学看護学雑誌,1, 1, 2005.

福島昭治
「智」「仁」「勇」を備えた若人像を求めて.大阪市立大学看護学科,1, 2005.

Kang, J.S., Morimura, K., Salim, E.I., Wanibuchi, H., Yamaguchi, S. and Fukushima, S.
Persistence of liver cirrhosis in association with proliferation of nonparenchymal cells and altered location of -smooth muscle actin-positive cells. Toxcol. Pathol., 33, 329-335, 2005.

Kang, J.S., Wanibuchi, H., Morimura, K., Puatanachokchai, R., Salim, E.I., Hagihara, A., Seki, S. and Fukushima, S.
Enhancement by estradiol 3-benzoate in thioacetamide-induced liver cirrhosis of rats. Toxicol. Sci., 85, 720-726, 2005.

河部真弓,今井則夫,難波江恭子,戸田庸介,市原敏夫,鰐渕英機,森村圭一朗,福島昭治
グルコサミンのラットを用いた90日間反復投与毒性試験.日本食品化学学会誌,12, 15-22, 2005.

Fukushima, S., Wanibuchi, H., Morimura, K., Nakae, D., Tsuda, H., Imaida, K., Shirai, T., Tatematsu, M., Tsukamoto, T., Hirose, M., Furukawa, F.
Lack of potential of low dose N-nitrosodimethylamine to induce preneoplastic lesions, glutathione S-transferase placental form-positive foci, in rat liver. Cancer Lett., 222, 11-15, 2005.

福島昭治,鰐渕英機,魏 民
尿路上皮癌.泌尿器外科,18, 671-674, 2005.

Doi, K., Wanibuchi, H., Salim, E.I., Morimura, K., Kinoshita, A., Kudoh, S., Hirata, K., Yoshikawa, J. and Fukushima, S.
Lack of large intestinal carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine at low doses in rats initiated with azoxymethane. Int. J. Cancer, 115, 870-878, 2005.

Hagiwara, A., Murai, T., Miyata E., Nabae, K., Doi, Y., Yoshino, H., Ichihara, T., Mori, S. and Fukushima, S.
Influence of strain and diet on hepatocarcinogenicity of N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) in rats: slight inhibition of preneoplastic

福島昭治
大阪がん学術セミナー.癌治療と宿主,17, 309-311, 2005.

福島昭治,鰐渕英機,森村圭一朗,魏 民
遺伝毒性発がん物質の閾値問題.環境変異原研究,27, 75-79, 2005.
Kuramoto, T., Morimura, K., Nomoto, T., Namiki, C., Hamada, S., Fukushima, S., Sugimura, T., Serikawa, T. and Ushijima, T.
Sparse and wavy hair: a new model for hypoplasia of hair follicle and mammary glands on rat chromosome 17. J. Hered., 96, 339-345, 2005.

Fukushima, S., Morimura, K., Wanibuchi, H., Kinoshita, A. and Salim, E.I.
Current and emerging challenges in toxicopathology: carcinogenic threshold of phenobarbital and proof of arsenic carcinogenicity using rat medium-term bioassays for carcinogens. Toxicol. Appl. Pharmacol., 207, S225-S229, 2005.

福島昭治
発がん物質の閾値に対する新しい息吹を求めて-国際シンポジウム「環境因子、特に遺伝毒性発がん物質の閾値:安全と安心の接点をめざして」の開催にあたって-.化学物質総合管理.短報.1, 441-444, 2005.

Fukushima, S., Kinoshita, A., Puatanachokchai, R., Kushida, M., Wanibuchi, H. and Morimura, K.
Hormesis and dose-response-mediated mechanisms in carcinogenesis: evidence for a threshold in carcinogenicity of non-genotoxic carcinogens. Carcinogenesis, 26, 1835-1845, 2005.

Murai, T., Mori, Y., Tatematsu, K., Koide, A., Hagiwara, A., Makino, S., Mori, S., Wanibuchi, H. and Fukushima, S.
Differences in susceptibility to N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis between SD/gShi rats with spontaneous hypospermatogenesis and SD/cShi rats with spontaneous hydronephrosis. Cancer Sci., 96, 637-644, 2005.

福島昭治
アスベストだけじゃない 発がん性のある環境化学物質.サイエンスウェブ,1, 24-29, 2005.

Kushida, M., Sukata, T., Uwagawa, S., Ozaki, K., Kinoshita, A., Wanibuchi, H., Morimura, K., Okuno, Y. and Fukushima, S.
Low dose DDT inhibition of hepatocarcinogenesis initiated by diethylnitrosamine in male rats: Possible mechanisms. Toxicol. Appl. Pharmacol., 208, 285-294. 2005.

Kushida, M., Wanibuchi, H., Morimura, K., Kinoshita, A., Kang, J. S., Puatanachokchai, R., Wei, M., Funae, Y and Fukushima, S.
Dose-dependence of Promotion of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline-induced rat hepatocarcinogenesis by ethanol: Evidence for a threshold. Cancer Sci., 96, 747-757, 2005.

福島昭治、前川昭彦
第三章環境化学物質による発がん.佐渡敏彦、福島昭治、甲斐倫明編,放射線および環境化学物質による発がん-本当に微量でも危険なのか?pp.43-80,医療科学社,2005.

Morimura, K., Kang, J. S., Wei, M., Wanibuchi, H., Tsuda, H. and Fukushima, S.
Lack of urinary bladder carcinogenicity of sodium L-ascobate in human c-Ha-ras proto-oncogene transgenic rats. Toxicol. Pathol., 33, 764-767, 2005.

Yamachika, T., Nakanishi, H., Yasui, K., Ikehara, Y., Niwa, T., Wanibuchi, H., Tatematsu, M. Fukushima, S.
Establishment and characterization of a human colonic mucinous carcinoma cell line with predominant goblet-cell differentiation from liver metastasis. Pathol. Int., 55, 550-557, 2005.

Nishikawa, M., Wanibuchi, H., Morimura, K., Kinoshita, A., Nishikawa, T., Hayashi, S., Yano, Y. and Fukushima, S.
N-acetylcysteine and S-methylcysteine inhibit MeIQx rat hepatocarcinogenesis in the post-intiation stage. Carcinogenesis, 27, 982-988, 2005.

2004年

Okina, M., Yoshida, K., Kuroda, K., Wanibuchi, H., Fukushima, S. and Endo, G.
Determination of trivalent methylated arsenicals in rat urine by liquid cheromatography-inductively coupled plasma mass spectrometry after solvent extraction. J. Chromatography B, 799, 209-215, 2004.

吉田 香,翁 昌子,北村真理,周  栩,鰐渕英機,圓藤吟史,黒田孝一.
食餌中のシステインおよび腸内細菌がヒ素の代謝に与える影響.生活衛生,48, 407-414, 2004.

福島昭治,合間敬三,木村嘉勝,櫻井治彦,松島泰次郎.
バイオを語る(2)今後の果たす役割と期待.20年のあゆみ.中央労働災害防止協会・日本バイオアッセイ研究センター,30-49,2004.

Morimura, K., Romanenko, A., Wei, M., Salim, E. I., Kinoshita, A., Wanibuchi, H., Vozianov, A. and Fukushima, S.
Possible distinct molecular carcinogenic pathways for bladder cancer in Ukraine, before and after the Chernobyl disaster. Oncology Reports, 11, 881-886, 2004.

Hoshi, M., Wanibuchi, H., Salim, E. I., Morimura, L., Murai, T., Nomura, T., Takaoka, K. and Fukushima, S.
Carcinogenic potential of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in severe combined immunodeficient (SCID) mice. J. Toxicol. Pathol., 17, 17-23, 2004.

Tagawa, Y., Salim, E. I. and Fukushima, S.
Histological and mucin histochemical study of colon ulcers induced in rats by a rapid freezing method. J. Toxicol. Pathol., 17, 31-35, 2004.

Mukohara, T., Kudoh, S., Matsuura, K., Yamauchi, S., Kimura, T., Yoshimura, N., Kanazawa, H., Hirata, K., Inoue, K., Wanibuchi, H., Fukushima, S. and Yoshikawa, J.
Activated akt expression has significant correlation with EGFR and TGF-α expressions in stage I NSCLC. Anticancer Res., 24, 11-18, 2004.

Doi, K., Wanibuchi, H., Salim, E.I., Shen, J., Wei, M., Mitsuhashi, M., Kudoh, S., Hirata, K. and Fukushima, S.
Revised rat multi-organ carcinogenesis bioassay for whole-body detection of chemopreventive agents: modifying potential of S-methylcysteine. Cancer Lett., 206, 15-26, 2004.

Tanaka, Y., Osugi, H., Morimura, K., Takemura, M., Ueno, M., Kaneko, M., Fukushima, S. and Kinoshita, H.
Effect of duodenogastric reflux on N-methyl-N'-nitro-N-nitrosoguanidine-induced glandular stomach tumorigenesis in Helicobacter pylori-infected Mongolian gerbils. Oncology Reports, 11, 965-971, 2004.

福島昭治
環境化学物質の発がんリスク?発がん物質のホルミシス現象.生活衛生,48, 1-2, 2004.

福島昭治
第20回日本毒性病理学会第5回国際毒性病理学会合同国際学術会議.仁澪.大阪市立大学医学部同窓会報,72,6,2004.

福島昭治
特別講演「環境中の発がん物質」.名古屋市立大学薬友会関西支部会報,6,10-12,2004.

Wei, M., Wanibuchi, H., Morimura, K., Salim, E.I., Moku, M., Doi, K., Mitsuhashi, M., Masuda, C., Shen, J., Kinoshita, A. and Fukushima, S.
Lack of preventive efficacy of FK228, a histone deacetlylase inhibitor, against N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in p53+/- and p53+/+ mice. Anticancer Res., 24, 785-790, 2004.

鰐渕英機
砒素の発がん性研究の現状.News Letter,40,10-11,2004.

Fukushima, S., Wanibuchi, H., Morimura, K., Iwai, S., Nakae, D., Kishida, H., Tsuda, H., Uehara, N., Imaida, K., Shirai, T., Tatematsu, M., Tsukamoto, T., Hirose, M. and Furukawa, F.
Existence of a threshold for induction of aberrant crypt foci in the rat colon with low doses of 2-amino-1-methyl-6-phenolimidazo[4, 5-b]pyridine. Toxicol. Sci., 80, 109-114, 2004.

鰐渕英機、柚木孝之、福島昭治
第4節がん.第2項化学発がん(幅広く化学発がんによるモデル).森脇和郎,山村研一,米川博通編,モデル動物の作製と維持,pp.763-772,(株)エル・アイ・シー,東京,2004.

Wanibuchi, H., Salim, E. I., Kinoshita, A., Shen, J., Wei, M., Morimura, K., Yoshida, K, Kuroda, K., Endo, G. and Fukushima, S.
Understanding arsenic carcinogenicity by the use of animal models. Toxicology and Applied Pharmacology, 198, 366-376, 2004.

Kuroda, K., Yoshida, K., Yoshimura, M., Endo, Y., Wanibuchi, H., Fukushima, S. and Endo G.
Microbial metabolite of dimethylarsinic acid is highly toxic and genotoxic. Toxicology and Applied Pharmacology, 198, 345-353, 2004.

Shen, J., Wanibuchi, H., Salim, E. I., Wei M., Yamachika, T. and Fukushima, S.
Inhibition of azoxymethane-induced colon carcinogenesis in rats due to JTE-522, a selective cyclooxygenase-2 inhibitor. Asian Pacific J. Cancer Prev., 5, 253-258, 2004.

鰐渕英機
身近なところからできるがんの予防.第85回市民医学講座,1-14,2004.

Hoshi, M., Morimura, K., Wanibuchi, H., Wei, M., Okochi, E., Ushijima, T., Takaoka, K. and Fukushima, S.
No-observed effect levels for carcinogenicity and for in vivo mutagenicity of a genotoxic carcinogen. Toxicol. Sci., 81, 273-279, 2004.

Mitsuhashi, M., Morimura, K., Wanibuchi, H., Hayashi, S., Kiyota, A., Wada, S., Nakatani, T. and Fukushima, S.
Di-n-butyl phthalate is toxic to the male reproductive system and its toxicity is enhanced by thioacetamide induced liver injury. J. Toxicol. Pathol., 17, 177-185, 2004.

Mitsuhashi, M., Morimura, K., Wanibuchi, H., Kiyota, A., Wada, S., Nakatani, T. and Fukushima, S.
Examination of the rat model of liver injury via thioacetamide (TAA) or cebon tetrachloride (CCl4). J. Toxicol. Pathol., 17, 219-222, 2004.

Sukata, T., Uwagawa, S., Ozaki, K., Sumida, K., Kikuchi, K., Kushida, M., Saito, K., Morimura, K., Oeda, K., Okuno, Y., Mikami, N. and Fukushima, S.
α2-Macroglobulin: A novel cytochemical marker characterizing preneoplastic and neoplastic rat liver lesions negative for hitherto established cytochemical markers. Am. J. Pathol., 165, 1479-1488, 2004.

福島昭治
真夏の夜の雑感.名古屋市立大学医学部同窓会会報,91,2-3,2004.

Fukushima, S.
Threshold of environmental carcinogens. J. Toxicol. Sci., 29, 256, 2004.

Wanibuchi, H. and Fukushima, S.
Analysis of arsenic carcinogenicity-using animal models. J.Toxicol. Sci., 29, 276, 2004.

福島昭治、森村圭一朗
食品と発癌物質 発癌物質との共存社会.医学のあゆみ,211, 809-814, 2004.

Hagihara, A., Miyamoto, K., Furuta, J., Hiraoka, N., Wakazono, K., Seki, S., Fukushima, S., Tsao, M-S., Sugimura, T. and Ushijima, T.
Identification of 27 5' CpG islands aberrantly methylated and 13 genes silenced in human pancreatic cancers. Oncogene, 23, 8705-8710, 2004.

Ichihara, T., Wanibuchi, H., Totsuka, Y., Morimura, K., Wei, M., Nakae, D. and Fukushima, S.
Induction of DNA-adducts and increase of 8-hydroxy-2-deoxyguanosine, but no development of preneoplastic lesions in offspring liver with transplacental and trans-breast milk exposure to 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in rats. Cancer Sci., 95, 943-948, 2004.

福島昭治、鰐渕英機、森村圭一朗
表在性膀胱癌のWHO新分類.膀胱癌治療:最新のストラテジー-臨床症例からのアプローチ-, 1, 6-8, 2004.

Kakuni, M., Senoh, H., Morimura, K., Wnibuchi, H., Takaba, K., Nagano, K. and Fukushima, S.
Absence of β-catenin mutations in mouse hepatoblastomas induced by N, N-dimethylformamide. J. Toxicol. Pathol., 17, 261-265, 2004.

2003年

Salim, E. I., Wanibuchi, H., Morimura, K., Wei, M., Mitsuhashi, M., Yoshida, K., Endo, G. and Fukushima, S.
Carcinogenicity of dimethylarsinic acid in p53 heterozygous knockout and wild-type C57BL/6J mice. Carcinogenesis, 24, 335-342, 2003.

魏 民
DMA誘発ラット大腸発癌モデルにおける新規COX-2選択的阻害剤JTE-522の抑制作用.日本がん予防研究会,News Letter, No. 35, p. 3-4, Mar., 2003.

福島昭治
毒性学の現状と将来-発がん物質と内分泌かく乱物質に対するリスク評価の立場から.日本化学会編,発端化学シリーズII電気化学/光化学/無機固体/環境ケミカルサイエンス,pp. 290-297, 丸善株式会社,2003.

Fukushima, S., Wanibuchi, H., Morimura, K., Wei, M., Nakae, D., Konishi, Y., Tsuda, H., Takasuka, N., Imaida, K., Shirai, T., Tatemetsu, M., Tsukamoto, T., Hirose, M. and Furukawa, F.
Lack of initiation activity in rat liver of low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline. Cancer Lett., 191, 35-40, 2003.

Tsuda, H., Fukushima, S., Wanibuchi, H., Morimura, K., Nakae, D., Imaida, K., Tatematsu, M., Hirose, M., Wakabayashi, K. and Moore, M.A.
Value of GST-P positive preneoplastic hepatic foci in dose-response studies of hepatocarcinogenesis: Evidence for practical thresholds with both genotoxic and nongenotoxic carcinogens. A review of recent work. Toxicol. Pthol., 31, 80-86, 2003.

Suzuki, T., Mizuo, K., Nakazawa, H., Funae, Y., Fushiki, S., Fukushima, S., Shirai, T. and Narita, M.
Prenatal and neonatal exposure to bisphenol-A enhances the central dopamine D1 receptor-mediated action in mice: Enhancement of the methamphetamine-induced abuse state. Neuroscience, 117, 639-644, 2003.

Mitsuhashi, M., Wanibuchi, H., Wei, M., Doi, K., Morimura, K., Masuca, C., Wada, S., Nakatani, T., Kakizoe, T. and Fukushima, S.
Lack of inhibition of BBN-induced bladder carcinogenesis in C57BL/6 mice by intravesical instillation of KRN 7000. J. Toxicol. Pathol., 16, 19-23, 2003.

Seike, N., Wanibuchi, H., Morimura, K., Wei, M., Nishikawa, T., Hirata, K., Yoshikawa, J. and Fukushima, S.
Enhancement of lung carcinogenesis by nonylphenol and genistein in a F344 rat muliorgan carcinogenesis model. Cancer Lett., 192, 25-36, 2003.

Karim, R., Wanibuchi, H., Wei, M., Morimura, K., Salim, E.I. and Fukushima, S.
Enhancing risk of ethanol on MeIQx-induces rat hepatocarcinogenesis is accompanied with increased levels of cellular proliferation and oxidative stress. Cancer Lett., 192, 37-47, 2003.

Mitsuhashi, M., Wanibuchi, H., Wei, M., Doi, K., Morimura, K., Masuda, C., Wads, S., Nakatani, T., Kakizoe, T. and Fukushima, S.
No inhibition of urinary bladder carcinogenesis in rats with interavesical instillation of α-galactocylceramide. Asian Pacific J. Cancer Prev., 4, 45-50, 2003.

Fukushima, S., Moore, M.A. and Tsuda, H.
Appropriate models and an understanding of carcinogenic mechanisms - requirements for hazard risk assessment. Asian Pacific J. Cancer Prev., 4, 75-78, 2003.

Romanenko, A., Morimura, K., Wanibuchi, H., Wei, M., Zaparin, W., Vinnichenko, W., Kinoshita, A., Vozianov, A. and Fukushima, S.
Urinary bladder lesions induced by persistent chronic low-dose ionizing radiation. Cancer Sci., 94, 328-333, 2003.

Nishikawa, T., Salim, E.I., Morimura, K., Kaneko, M., Ogawa, M., Kinoshita, A., Osugi, H., Kinoshita, H. and Fukushima, S.
High susceptibility of p53 knockout mice to esophageal and urinary bladder carcinogenesis induced by N, N-dibutylnitrosamine. Cancer Lett., 194, 45-54, 2003.

福島昭治,森村圭一朗.
チェルノブイリの原子力発電所事故による膀胱病変.W'Waves, 日本病態治療研究会誌,9, 24-25, 2003.

Wakasugi, K., Nakamura, A., Iida, A., Nishii, Y., Nakatani, N., Fukushima, S. and Tanabe, Y.
Novel and efficient method for esterification, amidation between carboxylic acids and equimolar amounts of alcohols, and amines utilizing Me2NSO2Cl and N, N-dimethylamines; its application to the synthesis of coumaperine, a natural chemopreventive dieneamide. Tetrahedron 59, 5337-5345, 2003.

Ogawa, M., Wanibuchi, H., Nishikawa, T., Yano, Y., Otani, S., Totsuka, Y., Wakabayashi, K., Nakae, D. and Fukushima, S.
Post-initiation inhibition of MeIQx hepatocarcinogenesis in rats by cysteine. Osaka City Med. J., 49, 21-30, 2003.

福島昭治
発癌物質の無作用用量を確認.Medical Academy News, 869号, 2003.

Kinoshita, A., Wanibuchi, H., Morimura, K., Wei, M., Shen, J., Imaoka, S., Funae, Y. and Fukushima, S.
Phenobarbital at low dose exerts hormesis in rat hepatocarcinogenesis by reducing oxidative DNA damage, altering cell proliferation, apoptosis and gene expression. Carcinogenesis, 24, 1389-1399, 2003.

Murai, T., Koide, A., Miyauchi, H., Inoue, S., Maruyama, T., Makino, S., Mori, S., Wanibichi, H., Mori, Y. and Fukushima, S.
Promoting effect of sodium l-ascorbate on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced renal pelvic carcinogenesis in SD/cShi rats of both sexes. J. Toxicol. Pathol. 16, 231-236, 2003.

Mukohara, T., Kudoh, S., Yamauchi, S., Kimura, T., Yoshimura, N., Kanazawa, H., Hirata, K., Wanibuchi, H., Fukushima, S., Inoue, K. and Yoshikawa, J.
Expression of epidermal growth factor receptor (EGFR) and downstream-activated peptides in surgically excised non-small-cell lung cancer (NSCLC). Lung Cancer, 41, 123-130, 2003.

Kitano, M., Ariki, Y., Wada, J., Tanabe, Y., Kikuzaki, H., Nakatani, N., Wanibuchi, H., Morimura, K., Hidaka, T. and Fukushima, S.
Lack of inhibitory effects of coumaperine from pepper on the promotion stage of chemical hepatocarcinogenesis in the rat. J. Toxicol. Pathol., 16, 161-164, 2003.

Mori, S., Murai, T., Morimura, K., Wanibuchi, H. and Fukushima, S.
Lack of influence of testicular castration or sialoadenectomy on sodium L-ascorbate promotion of urinary bladder carcinogenesis in male F344 rats. J. Toxicol. Pathol., 16, 165-170, 2003.

Salim, E.I. and Fukushima, S.
Chemopreventive potential of volatile oil from black cumin (Nigella sativa L.) seeds against rat colon carcinogenesis. Nutrition and Cancer, 45, 195-202, 2003.

Yoshida, K., Kuroda, K., Zhou, X., Inoue, Y., Date, Y., Wanibuchi, H., Fukushima, S. and Endo, G.
Urinary sulfur-containing metabolite produced by intestinal bacteria following oral administration of dimethylarsinic acid to rats. Chem. Res. Toxicol., 16, 1124-1129, 2003.

Vozianov, A. F., Romanenko, A. M. and Fukushima, S.
Urologic aspects of chronic long-term low doses radiation effects after the chornobyl accident. Urinary bladder lesions induced by persistent chronic low-dose ionizing radiation. In: Health Effects of Chornobyl Accident. (eds.) A. Vozianov, V. Bebeshko, D. Bazyka, A. Chumak, DIA Ltd., Kyiv, pp. 353-374, 2003.

鰐渕英機、森村圭一朗、魏民、福島昭治
環境発がん物質に闘値が存在するか, 大阪 医薬品協会会報, 第657号, p. 11-21, 2003.

Uwagawa, S., Ozaki, K., Sukata, T., Kushida, M., Okuno, Y. and Fukushima, S.
Lack of enhanced epithelial cell proliferation in the urinary bladder of heterozygous p53 knockout mice given sodium ortho-phenylphenate or uracil. J. Toxicol. Pathol., 16, 147-152, 2003.

Fukushima, S., Morimura, K. and Wanibuchi, H.
Theresholds for carcinogenicity of environmental carcinogens. J. Toxicol. Sci., 28, 241, 2003.

Shen, J., Wanibuchi, H., Salim, E.I., Wei, M., Kinoshita, A., Yoshida, K., Endo, G. and Fukushima, S.
Liver tumorigenicity of trimethylarsine oxide in male Fischer 344 rats-association with oxidative DNA damage and enhanced cell proliferation. Carcinogenesis, 24, 1827-1835, 2003.

福島昭治
環境因子の発がんリスク?発がんの閾値.FFIジャーナル,208, 1017-1027, 2003.
鰐渕英機、森村圭一朗、魏民、福島昭治
総論:低用量・長期曝露による環境発がん.分子予防環境医学?生命科学研究の予防・環境医学への統合?.本の泉社,pp.121-128, 2003.

Shen, J., Wanibuchi, H., Salim, E.I., Wei, M., Doi, K., Yoshida, K., Endo, G., Morimura, K. and Fukushima, S.
Induction of glutathione S-transferase placental form positive foci in liver and epithelial hyperplasia in urinary bladder, but no tumor development in male Fischer 344 rats treated with monomethylarsonic acid for 104 weeks. Toxicology and Applied Pharmacology, 193, 335-345, 2003.

Wei, M., Wanibuchi, H., Morimura, K. and Fukushima, S.
Carcinogenicity of dimethylarsinic acid and relevant mechanisms. In: Arsenic Exposure and Health Effects V, Chapter 16, (eds.) W.R. Chappell, C.O. Abernathy, R. L. Calderon, D. J. Thomas, Eesevier B. V., pp. 211-222, 2003.

Mitsuhashi, M., Wanibuchi, H., Morimura, K., Doi, K., Wei, M., Wada, S., Nakatani, T. and Fukushima, S.
Significace of overexpression of metallothionein in mouse urinary bladder focal lesions induced by treatment with N-butyl-N-(4-hydroxyburyl)-nitrosamine. Cancer Sci., 94, 1052-1058, 2003.

Wei, M., Morimura, K., Wanibuchi, H., Shen, J., Doi, K., Mitsuhashi, M., Moku, M., Salim, E.I. and Fukushima, S.
Chemopreventive effect of JTE-522, a selective cyclooxygenase-2 inhibitor, on 1,2-dimethylhydrazine-induced rat colon carcinogenesis. Cancer Lett, 202, 11-16, 2003.

Wanibuchi, H., Kang J. S., Salim E. I., Morimura, K. and Fukushima, S.
Toxicity vs. beneficial effects of phytoestrogens. In: Pure and Applied Chemistry, 75th Editor. (eds.) M. Junshi, B. Joanna, A. John, K. William, K. Werner, K. Kenneth, L. James, M. Peter, SCOPE/IUPAC, USA, pp. 2047-2054, 2003.

2002年

Cohen, S. M., Wanibuchi, H. and Fukushima, S.: Lower Urinary Tract. In
Handbook of Toxicologic Pathology. Second Edition. (eds.) Haschek, W. M., Rousseaux, C. G., Wallig, M. A., Academic press, Vol. 2, pp. 337-362, 2002.

Seike N., Wanibuchi, H., Morimura, K., Nishikawa, T., Kishida, H., Nakae, D., Hirata, K. and Fukushima, S.
Lack of promoting effect due to oral administration of dimethylarsinic acid on rat lung carcinogenesis initiated with N-bis(2-hydroxyproryl)nitrosamine. Cancer Le02tt., 175, 113-119, 2002.

福島昭治
がん予防と発がんリスク評価.Cancer prevention and risk assessment of environmental carcinogens. Foods Food Ingredients J., 巻頭言, No. 196, 1-4, 2002.
Kinoshita, A., Wanibuchi, H., Imaoka, S., Ogawa, M., Masuda, C., Morimura, K., Funae, Y. and Fukushima, S.
Formation of 8-hydroxydeoxyguanosine and cell-cycle arrest in the rat liver via generation of oxidative stress by phenobarbital: association with expression profiles of p21WAF1/Cip1, cyclin D1 and Ogg1. Carcinogenesis, 23, 341-349, 2002.

福島昭治
毒性学の現状と将来-発がん物質と内分泌撹乱物質に対するリスク評価の立場から-.21世紀の化学の潮流を探るNo.13環境ケミカルサイエンス持続可能な発展の化学をめざして,p. 61-65, 2002.

Iwai, S., Karim, R., Kitano, M., Sukata, T., Wei, M., Morimura, K., Wanibuchi, H. and Fukushima, S.
Role of oxidative DNA damage caused by carbon tetrachlorede-induced liver injury -enhancement of MeIQx-induced glutathione S-trandferase placental form-positive foci in rats. Cancer Lett., 179, 15-24, 2002.

Kakuni, M., Morimura, K., Wanibuchi, H., Ogawa, M., Min, W., Hayashi, S. and Fukushima, S.
Food restriction inhibits the growth of intestinal polyps in multiple intestinal neoplasia mouse. Jpn. J. Cancer Res., 93, 236-241, 2002.

Mori, Y., Koide, A., Kobayashi, Y., Morimura, K., Kaneko, M. and Fukushima, S.
Effect of ethanol treatment on metabolic activation and detoxification of esophagus carcinogenic N-nitrosamines in rat liver. Mutagenesis, 17, 251-256, 2002.

鰐渕英機,福島昭治
がん化学予防物質検出のための中期検索法:ラット肝中期発がん性試験法(伊東法)と多臓器中期発がん性試験法.FFIジャーナル,200, 43-47, 2002.

Sukata, T., Uwagawa, S., Ozaki, K., Ogawa, M., Nishikawa, T., Iwai, S., Kinoshita, A., Wanibuchi, H., Imaoka, S., Funae, Y., Okuno, Y. and Fukushima, S.
Detailed low-dose study of 1,1-bis(T-chlorophenyl)-2,2,2-trichloroethane carcinogenesis suggests the possibility of a hormetic effect. Int. J. Cancer, 99, 112-118, 2002.

Nishikawa, T., Wanibuchi, H., Ogawa, M., Kinoshita, A., Morimura, K., Hiroi , T., Funae, Y., Kishida, H., Nakae, D. and Fukushima, S.
Promoting effects of monomethylarsonic acid, dimethylarsinic acid and trimethylarsine oxide on induction of rat liver preneoplastic glutathione s-transferase placental form positive foci: a possible reactive species mechanism. Int. J. cancer, 100, 136-139, 2002.

Karim, R., Iwai, S., Morimura, K., Wanibuchi, H., Tanaka, R., Matsunaga, S., Yoshitake, A. and Fukushima, S.
Lack of modification of rat hepatpcarcinogenesis by fernane-type triterpenoids, lsolated from a euphorbia genus. Teratoge. Carcinoge. Mutage., 22, 293-299, 2002.

植田秀樹,石村栄治,奥野仙二,前川きよし,出雲谷剛,金昌雄,松本直樹,福本真也,今西康雄,絵本正憲,庄司哲雄,鰐渕英機,稲葉雅章,西沢良紀
内皮下沈着物を認め膜性増殖性糸球体腎炎の兄弟発症例.日本腎臓学会誌, 44, 420-426, 2002.

Kuramoto, T., Morimura, K., Yamashita, S., Okochi, E., Watanabe, N., Ohta, T., Ohki, M., Fukushima, S., Sugimura, T. and Ushizima, T.
Etiology-specific gene expression profiles in rat mammary carcinomas. Cancer Res., 62, 3592-3597, 2002.

Wei, M., Wanibuchi, H., Morimura, K., Iwai, S., Yoshida, K., Endo, G., Nakae,D. and Fukushima, S.
Carcinogenicity of dimethylarsinic acid in male F344 rats and genetic alterations in induced urinary bladder tumors. Carcinogenesis, 23, 1387-1397, 2002.

Kaneko, M., Morimura, K., Nishikawa, T., Wanibuchi, H., Osugi, H., Kinoshita, H., Koide, A., Mori, Y. and Fukushima, S.
Weak enhancing effects of simultaneous ethanol administration on chemically induced rat esophageal tumorigenesis. Oncology Reports, 9, 1069-1073, 2002.

Romanenko, A., Morimura, K., Wei, M., Zaparin, W., Vozianov, A. and Fukushima, S.
DNA damage repair in bladder urothelium after the chernobyl accident in ukraine. The Journal of Urology, 168, 973-977, 2002.

Salim, E. I., Wanibuchi, H., Morimura, K., Murai, T., Makino, S., Nomura, T. and Fukushima, S.
Induction of tumors in the colon and liver of the immunodeficient (SCID) mouse by 2-amino-3methylimidazo[4,5-?]quinoline (IQ)-modulation by long-chain fatty acids. Carcinogenesis, 23, 1519-1529, 2002.

鰐渕英機、福島昭治
砒素発がんの実験的証明とその機序.Biomed. Res. Trace Elements, 13, 200-208, 2002.

Osugi, H., Morimura, K., Okuda, E., Takemura, M., Higashino, M., Takada, N. and Kinoshita, H.
p53 null mutations detected by a p53 yeast functional assay predict a poor outcome in young esophageal carcinoma patients. International Journal of Oncology, 21, 637-641, 2002.

Osugi, H., Takemura, M., Morimura, K., Kaneko, M., Higashino, M., Takada, N., Lee, S. and Kinoshita, H.
Clinicopathologic and immunohistochemical features of surgically resected small call carcinoma of the esophagus. Oncology Reports, 9, 1245-1249, 2002.
Kaneko, M., Morimura, K., Nishikawa, T., Wanibuchi, H., Takada, N., Osugi, H., Kinoshita, H. and Fukushima, S.
Different genetic alterations in rat forestomach tumors induced by genotoxic and non-genotoxic carcinogens. Carcinogenesis, 23, 1729-1735, 2002.

福島昭治
発がん物質と内分泌攪乱物質に対する現状と将来:リスク評価の立場から.Foods Food Ingredients J. Jpn., 205, 52-56, 2002.

Wanibuchi, H., Ichihara, T., Morimura, K. and Fukushima, S.
Chemopreventive effects of ginseng on rat carcinogenesis. In: Advances in Ginseng Research 2002- Proceedings of the 8th International Symposium on Ginseng- (ed.) Han, Y.N., The Korean Society of Ginseng, pp.277-287, 2002.

Ichihara, T., Wanibuchi, H., Iwai, S., Kaneko, M., Tamano, S., Nishino, H. and Fukushima, S.
White, but not red, ginseng inhibits progression of intestinal carcinogenesis in rats. Asian Pacific J. Cancer Prev., 3, 243-250, 2002.

Fukushima, S., Wanibuchi, H., Morimura, K., Wei, M., Nakae, D., Konishi, Y., Tsuda, H., Uehara, N., Imaida, K., Shirai, T., Tatematsu, M., Tsukamoto, T., Hirose, M., Furukawa, F., Wakabayashi, K. and Totsuka, Y.
Lack of a dose-response relationship for carcinogenicity in the rat liver with low doses of 2-amino-3,8-dimethylimidazo[4,5-?]quinoxaline or N-nitrosodiethylamine. Jpn. J. Cancer Res., 93, 1076-1082, 2002.

福島昭治
膀胱癌のWHO新分類と日本の取扱い規約.表在性膀胱癌治療の新しい展開[基礎的側面],1-3, 2002.

福島昭治
病理学的事項.膀胱癌取扱い規約第3版改訂のポイント,7-9, 2002.

福島昭治、鰐渕英機、森村圭一朗、魏 民
環境因子の発がんリスク:環境発がん物質に閾値が存在するか.Kansai Journal of Laboratory Animals, 関西実験動物研究会会報,23, 58-68, 2002.

Wanibuchi, H., Morimura, K., Min, W., Ichihara, T., Yano, Y., Otani, S. and Fukushima, S.
Lack of Inhibitory effects of an anti-angiogenesis drug, TNP-470, on rat urinary bladder papillomatosis induced by mechanical stimulation. J. Toxicol. Pathol., 15, 197-201, 2002.

福島昭治
環境発がん物質の低濃度発がんリスクの解明.戦略的基礎研究推進事業平成8年度採択課題研究終了報告書「生体防御のメカニズム」,科学技術振興事業団,199-305, 2002

2001年

Masuda, C., Wanibuchi, H., Otori, K., Wei, M., Yamamoto, S., Hiroi, T., Imaoka, S., Funae, Y. and Fukushima, S.
Presence of a no-observed effect level for enhancing effects of development of the α-isomer of benzene hexachloride (α-BHC) on diethylnitrosamine-initiated hepatic foci in rats. Cancer Lett., 163, 179-185, 2001.

Fukushima, S., Takada, N., Wanibuchi, H., Hori. T., Min, W. and Ogawa, M.
Suppression of chemical carcinogenesis by water-soluble organosulfur componds. J. Nutr., 131, 1049-1053, 2001.

Hakoi, K., Hayashi, T., Irimura, K., Hayashi, S., Suzuki, S., Yamaguchi, S., Konishi, N. and Fukushima, S.
Alpha2u-globulin nephropathy in rats treated with a glycosaminoglycan extracted from sea cucumber. J. Toxicol. Pathol., 14, 13-18, 2001.

福島昭治,鰐渕英機,森村圭一朗
実験的膀胱癌とその化学予防.腎泌予防医誌. 9, 45-47, 2001.

Vijayaraghavan, M., Wanibuchi, H., Karim, R., Yamamoto, S., Masuda, C., Nakae, D., Konishi, Y. and Fukushima, S.
Dimethylarsinic acid induces 8-hydroxy-2’-deoxyguanosine formation in the kidney of NCI-Black-Reiter rats. Cancer Lett., 165, 11-17, 2001.

Okuda, E., Osugi, H., Morimura, K., Takada, N., Takemura, M., Fukushima, S., Higashino, M. and Kinoshita, H.
Detection of p53 gene mutations in human esophageal squamous cell carcinomas using a p53 yeast functional assay: Possible difference in esophageal carcinogenesis between the young and the elderly group. Clinical Cancer Res., 7, 600-606, 2001.

Iwai, S., Wei, M., Morimura, K., Wanibuchi, H., Tanaka, R., Matsunaga, S., Yoshitaka, A., Seki, S. and Fukushima, S.
Possible prevention by abieslactone of development of diethylnitrosamine-lnitiated GST-P positive foci in the rat liver. Teratoge. Carcinoge. Mutage., 21, 223-229, 2001.

Wada, S., Yoshimura, R., Masuda, C., Hase, T., Ikemoto, S., Kishimoto, T. and Fukushima, S.
Are tobacco use and urine pH indicated as risk factors for bladder carcinoma? Int. J. Urol., 8, 106-109, 2001.
Yoshida, K., Kuroda, K., Inoue, Y., Chen, H., Wanibuchi, H., Fukushima, S. and Endo, G.
Metabolites of arsenobetaine in rats: does decomposition of arsenobetaine occur in mammals?+ Applied Organometallic Chem., 15, 271-276, 2001.

Yoshida, K., Kuroda, K., Inoue, Y., Chen, H., Date, Y., Wanibuchi, H., Fukushima, S. and Endo, G.
Metabolites of dimethylarsinic acid in rats: production of unidentified metabolites in vivo. Applied Organometallic Chem., 15, 539-547, 2001.

Kuroda, K., Yoshida, K., Yasukawa, A., Wanibuchi, H., Fukushima, S. and Endo, G.
Enteric bacteria may play a role in mammalian arsenic metabolism. Applied Organometallic Chem., 15, 548-552, 2001.

Fukushima, S.
Possible involvement of O6-methylguanine formation and p53 dysfunction in mouse urinary bladder carcinogenesis. Mut. Res., 477, 125-130, 2001.

Morimura, K., Hori, T., Kaneko, M., Nishikawa, T., Nishikawa, A., Wanibuchi, H., Takada, N., Osugi, H. and Fukushima, S.
Promotion of chemically induced rat esophageal tumorigenesis with post-initiation ethanol modification. Teratoge. Carcinoge. Mutage., 21, 295-301, 2001.

森村圭一朗,鰐渕英機,福島昭治
イニシエーション,プロモーション-多段階発癌.Molecular Medicine, 38, 944-947, 2001.

北野光昭,鰐渕英機,森村圭一朗,福島昭治
癌原因子のリスク評価・血液・腫瘍科, 42, 511-516, 2001.

Mori, Y., Koide, A., Fuwa, K., Wanibuchi, H. and Fukushima, S.
Lack of change in the levels of liver and kidney cytochrome P-450 isozymes in p53; (+/-) knockout mice treated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Mutagenesis, 16, 377-383, 2001.

Fukushima, S., Wanibuchi, H., Wei, M., Salim, E.I. and Morimura, K.
Carcinogenicity of dimethylarsinic acid, an inorganic arsenic metabolite, in rodents. In: Surgical pathology update 2001, 18th European congress of pathology, (eds.) Hauptmann, S., Dietel, M., Sobrinho-Simoes., M., ABW Wissenschaftsverlag, Berlin, Germany, pp. 480-483, 2001.

福島昭治
大きく躍進する医学部.2002年版大学入試シリーズ、大阪市立大学理系 -前期日程,pp.11-12,教学社,2001.

Romanenko, A., Morimura, K., Wanibuchi, H., Wei, M., Zaparin, W., Vinnichenko, W., Kinoshita, A., Vozianov, A. and Fukushima, S.
Correspondence re: W. Paile’s Letter to the editor. Cancer Res., 61, 6964-6965, 2001.

福島昭治
ウクライナ国立泌尿器疾患研究所での共同研究討議と第18回ヨーロッパ病理学会出席を終えて.国際学術研究交流委員会報告,2001.

Ozono, S., Hinotsu, S., Tabata, S., Takashima, K., Fujimoto, K., Okajima, E., Hirai, Y., Ohashi, Y., Akaza, H., Fukushima, S. and Nara
Uro-Oncology Research Group: Treated natural history of superficial bladder cancer. Jpn. J. Clin. Oncol., 31(11), 536-540, 2001.

Gen, H., Yamamoto, S., Morimura, K., Wei, M., Mitsuhashi, M., Murai, T., Mori, S., Hosono, M., Oohara, T., Makino, S., Wanibuchi, H. and Fukushima, S.
p53 and H-ras mutations and microsatellite instability in renal pelvic carcinomas of NON/Shi mice treated with N-Butyl-N-(4-hydroxybutyl)-nitrosamine: Different genetic alteration from urinary bladder carcinoma. Jpn. J. Cancer Res., 92, 1278-1283, 2001.

Fukushima, S., Wanibuchi, H. and Li, W.
Inhibition by ginseng of colon carcinogenesis in rats. Journal of Korean Medical Science, 16 (Suppl), S75-80, 2001.

Fukushima, S.
16th Japanese pathology for carcinogenesis Meeting (hatsugan-byori kenkyukai). Asian Pacific J. Cancer Prev., 243, 2001.

Yachida, S., Matsushita, K., Usuki, H., Wanibuchi, H., Maeba, T. and Maeta, H.
Long-term survival after resection for small cell carcinoma of the esophagus. Ann Thorac Surg., 72, 596-597, 2001