Molecular and neural mechanisms
of fatigue and fatigue sensation
--- For better recovery and better avoidance from exhaustion
Yausyoshi Watanabe
Department of Physiology, Osaka City University Graduate School
of Medicine, and Osaka Bioscience Institute
1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan
yywata@med.osaka-cu.ac.jp
A variety of causes induce fatigue. There
are commonalty and diversity in the mechanisms of different types
of fatigue. As many of the researchers suggested, neuro-immuno-endocrine
interaction and neuroimmuno-psychiatric modulation are the central
issues in the research on the mechanisms of fatigue. We feel fatigue
in our brain, but the sense of fatigue has not been so highlighted
before, unlike pain or fever, although fatigue is an indispensable
bioalarm for us in analogy to pain and fever. Here, in this homepage,
I would like to introduce the framework of our project "Molecular/neural
mechanisms of fatigue and fatigue sensation and the development
of the way to overcome fatigue" (1999-2005) through Special
Coordination Funds for Promoting Science and Technology from the
Ministry of Education, Culture, Sports, Science and Technology (MEXT),
the Japanese Government, and the summary of our performances and
results for the past four years.
Since the goal of our project is better prevention of fatigue
and better recovery from fatigue, we have to make attempts to collect,
assess, and invent the ways for those, in parallel with our efforts
to explore the molecular and neural mechanisms of fatigue.
The project has been done by the members of researchers in various
laboratories and institutions. The list of members is shown in Table
1 with their titles or themes of the research.
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