業績集

2015年

01.: Mizuno, K., Tanaka, M., Tanabe, H.C., Joudoi, T., Kawatani, J., Shigihara, Y., Tomoda, A., Miike, T., Imai-Matsumura, K., Sadato, N., and Watanabe, Y.: Less efficient and costly processes of frontal cortex in childhood chronic fatigue syndrome. Neuroimage Clin., 9: 355-368, 2015.
02.: Yamano, E., Ishii, A., Tanaka, M., Nomura, S., and Watanabe, Y.: Neural basis of individual differences in the response to mental stress: a magnetoencephalography study. Brain Imaging Behav., 1-12, 2015.[Epub 2015 Nov 19]
03.: Tanaka, M., Ishii, A., Watanabe, Y.: Physical fatigue increases neural activation during eyes-closed state: a magnetoencephalography study. Behav. Brain Funct., 11(1): 35, 2015.
04.: Tanaka, M., Tajima, S., Mizuno, K., Ishii, A., Konishi, Y., Miike, T., and Watanabe, Y.: Frontier studies on fatigue, autonomic nerve dysfunction, and sleep-rhythm disorder. J. Physiol. Sci., 65(6): 483-498, 2015.
05.: Mizuno, K., Takiguchi, S., Yamazaki, M., Asano, M., Kato, S., Kuriyama, K., Watanabe, Y., Sadato, N., and Tomoda, A.: Impaired neural reward processing in children and adolescents with reactive attachment disorder: a pilot study. Asian J. Psychiatr., 17: 89-93, 2015.
06.: Tominaga, K., Tsumoto, C., Ataka, S., Mizuno, K., Takahashi, K., Yamagami, H., Tanigawa, T., Kawabe, J., Watanabe, T., Fujiwara, Y., Shiomi, S., Watanabe, Y., and Arakawa, T.: Regional brain disorders of serotonin neurotransmission are associated with functional dyspepsia. Life Sci., 137: 150-157, 2015.
07.: Doi, H., Mawatari, A., Kanazawa, M., Nozaki, S., Nomura, Y., Kitayoshi, T., Akimoto, K., Suzuki, M., Ninomiya, S., and Watanabe, Y.: Synthesis of 11C-labeled thiamine and fursultiamine for in vivo molecular imaging of vitamin B1 and its prodrug using positron emission tomography. J. Org. Chem., 80(12): 6250-6258, 2015.　　　　　　　　　　　　
08.: Takahashi, K., Mizuno, K., Sasaki, A.T., Wada, Y., Tanaka, M., Ishii, A., Tajima, K., Tsuyuguchi, N., Watanabe, K., Zeki, S., and Watanabe, Y.: Imaging the passionate stage of romantic love by dopamine dynamics. Front. Hum. Neurosci., 9:191, 2015.　　　　　　　　　　　　
09.: Kurihara, H., Hamada, A., Yoshida, M., Shimma, S., Hashimoto, J., Yonemori, K., Tani, H., Miyakita, Y., Kanayama, Y., Wada, Y., Kodaira, M., Yunokawa, M., Yamamoto, H., Shimizu, C., Takahashi, K., Watanabe, Y., Fujiwara, Y., and Tamura, K.: 64Cu-DOTA-trastuzumab PET imaging and HER2 specificity of brain metastases in HER2-positive breast cancer patients. EJNMMI Res., 5: 8, 2015.　　　　　　　　　　　　
10.: Ishii, A., Karasuyama, T., Kikuchi, T., Tanaka, M., Yamano, E., and Watanabe, Y.: The neural mechanisms of re-experiencing mental fatigue sensation: a magnetoencephalography study. PLos One, 10(3): e01122455, 2015.
11.: Kume, S., Yamato, M., Tamura, Y., Jin, G., Nakano, M., Miyashige, Y., Eguchi, A., Ogata, Y., Goda, K., Iwai, K., Yamano, E., Watanabe, Y., Soga, T., and Kataoka, Y.: Potential biomarkers of fatigue identified by plasma metabolome analysis in rats. PLos One, 10(3): e0120106, 2015.
12.: Fukuda, S., Koyama, H., Kondo, K., Fujii, H., Hirayama, Y., Tabata, T., Okamura, M., Yamakawa, T., Okada, S., Hirata, S., Kiyama, H., Kajimoto, O., Watanabe, Y., Inaba, M., and Nishizawa, Y.: Effects of nutritional supplementation on fatigue, and autonomic and immune dysfunction in patients with end-stage renal disease: a randomized, double-blind, placebo-controlled, multicenter trial. PLoS One, 10(3): e0119578, 2015.
13.: Shingaki, T., Hume, W.E., Takashima, T., Katayama, Y., Okauchi, T., Hayashinaka, E., Wada, Y., Cui, Y., Cui, Y., Kusuhara, H., Sugiyama, Y., and Watanabe, Y.: Quantitative Evaluation of mMate1 Function Based on Minimally Invasive Measurement of Tissue Concentration Using PET with [11C]Metformin in Mouse. Pharm. Res., 32(8): 2538-2547, 2015.
14.: Goto, M., Mizuma, H., Wada, Y., Suzuki, M., Watanabe, Y., Onoe, H., and Doi, H.: 11C-Labeled capsaicin and its in vivo molecular imaging in rats by positron　emission tomography. Food Nutr. Sci., 6: 216-220, 2015.
15.: Fujii, H., Fukuda, S., Narumi, D., Ihara, T., and Watanabe, Y.: Fatigue and sleep under large summer temperature differences. Environ. Res., 138: 17-21, 2015.
16.: Cui, Y., Toyoda, H., Sako, T., Onoe, K., Hayashinaka, E., Wada, Y., Yokoyama, C., Onoe, H., Kataoka, Y., and Watanabe, Y.: A voxel-based analysis of brain activity in high-order trigeminal pathway in the rat induced by cortical spreading depression. NeuroImage, 108:17-22, 2015.

2014年

01.: Ishii, A., Tanaka, M., Watanabe, Y.: The neural mechanisms underlying the decision to rest in the presence of fatigue: a magnetoencephalography study. PLos One, 9(10): e109740, 2014.
02.: Cui, Y., Kataoka, Y., Watanabe, Y.: Role of cortical spreading depression in the pathophysiology of migraine. Neurosci. Bull., 30(5): 812-822, 2014.
03.: Mizuno, K., Tajima, K., Kuratsune, H., and Watanabe, Y.: Fatigue correlates with the decrease in parasympathetic sinus modulation induced by a cognitive challenge. Behav. Brain. Funct., 10(1): 25, 2014.
04.: Zhang, Z., Doi, H., Koyama, H., Watanabe, Y., and Suzuki, M.: Efficient syntheses of [11C]zidovudine and its analogs by convenient one-pot palladium(0)-copper(I) co-mediated rapid C-[11C]methylation. J. Labelled. Comp. Radiopharm., 57(8): 540-549, 2014.
05.: Yoshikawa, T., Tanaka, M., Ishii, A., and Watanabe, Y.: Association of fatigue with emotional eating behavior and the response to mental stress in food intake in a young adult population. Behav. Med., 4(4): 149-153, 2014.
06.: Suzuki, M., Doi, H., Koyama, H., Zhang, Z., Hosoya, T., Onoe, H., and Watanabe, Y.: Pd(0) -Mediated Rapid Cross-Coupling Reactions, the Rapid C-[11C]Methylations, Revolutionarily Advancing the Syntheses of Short-Lived PET Molecular Probes. Chem. Rec., 14(3): 516-541, 2014.
07.: Ishii, A., Tanaka, M., Watanabe, Y.: Neural mechanisms of mental fatigue. Rev. Neurosci., 25(4): 516-541, 2014.
08.: Narita, A., Shiomi, S., Kawabe, J., Tsushima, H., Yamanaga, T., and Watanabe, Y.: Validation of threshold method for myocardial control database by use of clinical data. Radiol. Phys. Technol., 7(2): 340-351, 2014.
09.: Ohnishi, A., Senda, M., Yamane, T., Sasaki, M., Mikami, T., Nishio, T., Ikari, Y., Nishida, H., Shukuri, M., Takashima, T., Mawatari, A., Doi, H., Watanabe, Y., and Onoe, H.: Human whole-body biodistribution and dosimetry of a new PET tracer, [11C]ketoprofen methyl ester, for imagings of neuroinflammation. Nucl. Med. Biol., 41(7): 594-599, 2014.
10.: Yoshikawa, T., Tanaka, M., Ishii, A., Watanabe, Y.: Suppressive responses by visual food cues in postprandial activities of insular cortex as revealed by magnetoencephalography. Brain Res., 1568: 31-41, 2014.
11.: Ishii, A., Tanaka, M., Watanabe, Y.: The neural substrates of self-evaluation of mental fatigue: a magnetoencephalography study. PLos One, 9(4): e95763, 2014.
12.: Nakatomi, Y., Mizuno, K., Ishii, A., Wada, Y., Tanaka, M., Tazawa, S., Onoe, K., Kawabe, J., Takahashi, K., Kataoka, Y., Shiomi, S., Yamaguti, K., Inaba, M., Kuratsune, H., and Watanabe, Y.: Neuroinflammation in patients with chronic fatigue syndrome/myalgic encephalomyelitis: a 11C-(R)-PK11195 positron emission tomography study. J. Nucl. Med., 55(6):945-950, 2014.
13.: Takahashi, K., Hosoya, T., Onoe, K., Doi, H., Nagata, H., Hiramatsu, T., Li, X.L., Watanabe, Yu., Wada, Y., Takashima, T., Suzuki, M., Onoe, H., and Watanabe, Y.: [11C]Cetrozole: an improved C-[11C]methylated PET probe for aromatase imaging in the brain. J. Nucl. Med., 55(5): 852-857, 2014.
14.: Tanaka, M., Ishii, A., Watanabe, Y.: Neural effects of mental fatigue caused by continuous attention load: A magnetoencephalography study. Brain Res., 1561: 60-66, 2014.
15.: Nomura, S., Nozaki, S., Hamazaki, T., Takeda, T., Ninomiya, E., Kudo, S., Hayashinaka, E., Wada, Y., Hiroki, T., Fujisawa, C., Kodama, H., Shintaku, H., and Watanabe, Y.: PET Imaging analysis with 64Cu in disulfiram treatment for aberrant copper bio-distribution in menkes disease mouse model. J. Nucl. Med., 55(5): 845-851, 2014.
16.: Yamato, M., Tamura, Y., Eguchi, A., Kume, S., Miyashige, Y., Nakano, M., Watanabe, Y., and Kataoka, Y.: Brain interleukin-1β and the intrinsic receptor antagonist control peripheral Toll-like receptor 3-mediated suppression of spontaneous activity in rats. PLos One, 9(3): e90950, 2014.
17.: Tanaka, M., Ishii, A., Watanabe, Y.: Regulatory mechanism of performance in chronic cognitive fatigue. Med. Hypotheses., 82(5): 567-571, 2014.
18.: Mukai, H., Ozaki, D., Cui, Y., Kuboyama, T., Yamato-Nagata, H., Onoe, K., Takahashi, M., Wada, Y., Imanishi, T., Kodama, T., Obika, S., Suzuki, M., Doi, H., and Watanabe, Y.: Quantitative evaluation of the improvement in the pharmacokinetics of a nucleic acid drug delivery system by dynamic PET imaging with (18)F-incorporated oligodeoxynucleotides. J. Control. Release, 180: 92-99, 2014.
19.: Tanaka, M., Ishii, A., Watanabe, Y.: Neural effect of mental fatigue on physical fatigue: a magnetoencephalography study. Brain Res., 1542: 49-55, 2014.
20.: Yoshikawa, T., Tanaka, M., Ishii, A., Fujimoto, S., and Watanabe, Y.: Neural regulatory mechanism of desire for food: revealed by magnetoencephalography. Brain Res., 1543: 120-127, 2014.

2013年

01.: Hume, W.E., Shingaki, T., Takashima, T., Hashizume, Y., Okauchi, T., Katayama, Y., Hayashinaka, E., Wada, Y., Kusuhara, H., Sugiyama, Y., and Watanabe, Y.: The synthesis and biodistribution of [11C]metformin as a PET probe to study hepatobiliary transport mediated by the multi-drug and toxin extrusion transporter 1 (MATE1) in vivo. Bioorg. Med. Chem., 21(24):7584-7590, 2013.
02.: Sako, T., Hasegawa, K., Nishimura, M., Kanayama, Y., Wada, Y., Hayashinaka, E., Cui, Y., Kataoka, Y., Senda, M., and Watanabe, Y.: Positron emission tomography study on pancreatic somatostatin receptors in normal and diabetic rats with 68Ga-DOTA-octreotide: A potential PET tracer for beta cell mass measurement. Biochem. Biophys. Res. Commun., 442(1-2): 79-84, 2013.
03.: Tanaka , M., Ishii, A., Watanabe, Y.: Neural mechanism of facilitation system during physical fatigue. PLoS One, 8(11): e80731, 2013.
04.: Mizuno, K., Yoneda, T., Komi, M., Hirai, T., Watanabe, Y., and Tomoda, A.: Osmotic release oral system-methylphenidate improves neural activity during low reward processing in children and adolescents with attention-deficit/hyperactivity disorder. Neuroimage: Clinical, 2: 366-376, 2013.
05.: Långström, B., Karimi, F., and Watanabe, Y.: Endogenous compounds labeled with radionuclides of short half-life-some perspectives. J. Labelled Compd. Rad., 56(3-4): 251-262, 2013.
06.: Tanaka , M., Ishii, A., Watanabe, Y.: Neural mechanisms underlying chronic fatigue. Rev Neurosci., 11: 1-12, 2013.
07.: Sunami, K., Ishii, A., Takano, S., Yamamoto, H., Sakashita, T., Tanaka, M., Watanabe, Y.,and Yamane, H.: Neural mechanisms of phonemic restoration for speech comprehension revealed by magnetoencephalography. Brain Res., 1537: 164-173, 2013.
08.: Tamura, K., Kurihara, H., Yonemori, K., Tsuda, H., Suzuki, J., Kono, Y., Honda, N., Kodaira, M., Yamamoto, H., Yunokawa, M., Shimizu, C., Hasegawa, K., Kanayama, Y., Nozaki, S., Kinoshita, T., Wada, Y., Tazawa, S., Takahashi, K., Watanabe, Y., and Fujiwara, Y.: 64Cu-DOTA-Trastuzumab PET Imaging in Patients with HER2-Positive Breast Cancer. J. Nucl. Med., 54(11): 1869-1875, 2013.
09.: Tanaka, M., Ishii, A., Watanabe, Y.: Neural mechanism of central inhibition during physical fatigue: A magnetoencephalography study. Brain Res., 1537:117-124, 2013.
10.: Shingaki, T., Takashima, T., Ijuin, R., Zhang, X., Onoue, T., Katayama, Y., Okauchi, T., Hayashinaka, E., Cui, Y., Wada, Y., Suzuki, M., Maeda, K., Kusuhara, H., Sugiyama, Y., and Watanabe, Y.: Evaluation of Oatp and Mrp2 activities in hepatobiliary excretion using newly developed positron emission tomography tracer [11C]dehydropravastatin in rats. J. Pharmacol. Exp. Ther., 347(1): 193-202, 2013.
11.: Tanaka, M., Ishii, A., Watanabe, Y.,: Neural Correlates of Central Inhibition during Physical Fatigue. PLoS One, 8(7): e70949, 2013.
12.: Yoshikawa, T., Tanaka, M., Ishii, A., and Watanabe, Y.: Neural effects of prolonged mental fatigue: A magnetoencephalography study.　Med. Sci. Monit., 19: 631-640, 2013.
13.: Ishii, A., Tanaka, M., Shigihara, Y., Kanai, E., Funakura, M., and Watanabe, Y.: Neural effects of prolonged mental fatigue: A magnetoencephalography study. Brain Res., 1529: 105-112, 2013.
14.: Yamano, E., Tanaka, M., Ishi, A., Tsuruoka, N., Abe, K., and Watanabe, Y.: Effects of chicken essence on recovery from mental fatigue. Med. Sci. Monit., 19: 540-547, 2013.
15.: Ishii, A.,Tanaka, M., Iwamae, M., Kim, C., Yamano, E., and Watanabe, Y.: Fatigue sensation induced by the sounds associated with mental fatigue and its related neural activities: revealed by magnetoencephalography. Behav. Brain. Funct., 9: 24, 2013.
16.: Kimura, T., Sako, T., Siqin, Hosokawa-Muto, J., Cui, Y.L., Wada, Y., Kataoka, Y., Doi, H., Sakaguchi, S., Suzuki, M., Watanabe, Y., and Kuwata, K.: Synthesis of an 11 C-Labeled Antiprion GN8 Derivative and Evaluation of Its Brain Uptake by Positron Emission Tomography. ChemMedChem, 8(7): 1035-1039, 2013.
17.: Miyajima, M., Kusuhara, H., Takahashi, K., Takashima, T., Hosoya, T., Watanabe, Y., and Sugiyama, Y.: Investigation of the effect of active efflux at the blood-brain barrier on the distribution of nonsteroidal aromatase inhibitors in the central nervous system. J. Pharm. Sci., 102(9): 3309-3319, 2013.
18.: Mizuno, K., and Watanabe, Y.: Neurocognitive impairment in childhood chronic fatigue syndrome. Front. Physiol., 4:87, 2013.
19.: Mukai, H., Wada, Y., and Watanabe, Y.: The synthesis of 64Cu-chelated porphyrin photosensitizers and their tumor-targeting peptide conjugates for the evaluation of target cell uptake and PET image-based pharmacokinetics of targeted photodynamic therapy agents. Ann. Nucl. Med., 27(7): 625-639, 2013.
20.: Yoshikawa, T., Orita, K., Watanabe, Y., and Tanaka, M.: Relationship between appetitive motives and non-exercise lifestyle in a young adult population. Med. Sci. Monit., 19:289-294, 2013.
21.: Takashima, T., Shingaki, T., Katayama, Y., Hayashinaka, E., Wada, Y., Kataoka, M., Ozaki, D., Doi, H., Suzuki, M., Ishida, S., Hatanaka, K., Sugiyama, Y., Akai, S., Oku, N., Yamashita, S., and Watanabe, Y.: Dynamic analysis of fluid distribution in the gastrointestinal tract in rats: Positron emission tomography imaging after oral administration of nonabsorbable marker, [18F]Deoxyfluoropoly(ethylene glycol). Mol. Pharm., 10(6): 2261-2269, 2013.
22.: Nakamura, I., Hasegawa, K., Wada, Y., Hirase, T., Node, K., and Watanabe, Y.: Detection of early stage atherosclerotic plaques using PET and CT fusion imaging targeting P-selectin in low density lipoprotein receptor-deficient mice. Biochem. Biophys. Res. Commun., 433(1):47-51, 2013.
23.: Kawachi, E., Uehara, Y., Hasegawa, K., Yahiro, E., Ando, S., Wada, Y., Yano, T., Nishikawa, H., Shiomi, M., Miura, S., Watanabe, Y., and Saku, K.: Novel molecular imaging of atherosclerosis with 68Ga-labeled apo A-I minetic peptide and PET. Circ. J., 77(6): 1482-1489, 2013.
24.: Cui, Y., Li, Q.H., Yamada, H., Watanabe, Y., and Kataoka, Y.: Chronic degeneration of dorsal raphe serotonergic neurons modulates cortical spreading depression: A possible pathophysiology of migraine. J. Neurosci. Res., 91(6):737-44, 2013.
25.: Fujii, H., Koyama, H., Fukuda, S., Tokai, H., Tajima, S., Koizumi, JI., Yamaguti, K., Kuratsune, H., Watanabe, Y., Hirayama, Y., Shoji, T., Inaba, M., and Nishizawa, Y.: Autonomic function is associated with health-related quality of life in patients with end-stage renal disease: A case-control study. J. Ren. Nutr., 23(5): 340-347, 2013.
26.: Tanaka, M., Yamada, H., Nakamura, T., Ishii, A., and Watanabe, Y.: Fatigue-recovering effect of a house designed with open space. Explore-J Sci. Heal., 9(2): 82-86, 2013.
27.: Iwata, T., Tanaka, K., Tahara, T., Nozaki, S., Onoe, H., Watanabe, Y., and Fukase, K.: A conformationally fixed analog of the peptide mimic Grb2-SH2 domain: synthesis and evaluation against the A431 cancer cell. Mol. Biosyst., 9(5): 1019-1025, 2013.
28.: Hayashi, T., Shimazawa, M., Watabe, H., Ose, T.,Inokuchi, Y., Yamanaka, H., Urayama, SI., Watanabe, Y., Hara, H., and Onoe, H.: Kinetics of neurodegeneration based on a risk-related biomarker in animal model of glaucoma. Mol. Neurodegener., 8(1): 4, 2013.
29.: Shigihara, Y., Tanaka, M., Ishii, A., Tajima, S., Kanai, E., Funakura, M., and Watanabe, Y.: Two different types of mental fatigue produce different styles of task performance. Neurol. Psychiatry Brain Res., 19(1): 5-11, 2013.
30.: Shigihara, Y., Tanaka, M., Ishii, A., Kanai, E., Funakura, M., and Watanabe, Y.: Two types of mental fatigue affect spontaneous oscillallatory brain activities in different ways. Behav. Brain Funct., 9(1): 2, 2013.
31.: Takashima, T., Wu, C., Takashima-Hirano, M., Katayama, Y., Wada, Y., Suzuki, M., Kusuhara, H., Sugiyama, Y., and Watanabe, Y.: Evaluation of breast cancer resistance protein function in hepatobiliary and renal excretion using PET with [11C]SC-62807. J. Nucl. Med., 54(2): 183-186, 2013.
32.: Fukuda, S., Horiguchi, M., Yamaguti, K., Nakatomi, Y., Kuratsune, H., Ichinose, H., and Watanabe, Y.: Association of monoamine-synthesizing genes with the depression tendency and personality in chronic fatigue syndrome patients. Life Sci., 92(3) 183-186, 2013.
33.: Mizuno, K., Tanaka, M., Fukuda, S., Imai-Matsumura, K., and Watanabe, Y.: Divided attention of adolescents related to lifestyles and academic and family conditions. Brain Dev., 35(5): 435-440, 2013.

2012年

01.: Tanaka, M., Ishii, A., Shigihara, Y., Tajima, S., and Watanabe, Y.: Impaired selective attention caused by mental fatigue. J. Neurol. Sci.-Turk., 29(3): 542-553, 2012.
02.: Yamamoto, S., Ouchi, Y., Nakatsuka, D., Tahara, T., Mizuno, K., Tajima, S., Onoe, H., Yoshikawa, E., Tsukada, H., Iwase, M., Yamaguti, K., Kuratsune, H., and Watanabe, Y.: Reduction of 11C-(+)3-MPB binding in brain of chronic fatigue syndrome with serum autoantibody against muscarinic cholinergic receptor. PLoS One, 7(12): e51515, 2012.
03.: Tanaka, M., Ishii, A., Yamano, E., Ogikubo, H., Okazaki, M., Kamimura, K., Konishi, Y., Emoto, S., and Watanabe, Y.: Cognitive dysfunction in elderly females with depressive symptoms. Med. Sci. Monit., 18(12): CR706-711, 2012.
04.: Yoshikawa, T., Orita K., Watanabe, Y., and Tanaka, M.: Validation of the Japanese version of the power of food scale in a young adult population. Psychol. Rep., 111(1): 253-265, 2012.
05.: Watanabe Y.: New findings on the underlying neural mechanism of emotion induced by frightening music. J. Nucl. Med., 53(10): 1497-1498, 2012.
06.: Tanaka, M., Shigihara, Y., Ishii, A., Funakura, M., Kanai, E., and Watanabe, Y.: Effect of mental fatigue on the central nervous system: an electroencephalography study. Behav. Brain. Funct., 8(1):48, 2012.
07.: Takeuchi, J., Shimada, H., Ataka, S., Kawabe, J., Mori, H., Mizuno, K., Wada, Y., Shiomi, S., Watanabe, Y., and Miki, T.: Clinical features of pittsburgh compound-B-negative dementia. Dement. Geriatr. Cogn. Disord., 34(2): 112-120, 2012.
08.: Tanaka, M., Ishii, A., Yamano, E., Ogikubo, H., Okazaki, M., Kamimura, K., Konishi, Y., Emoto, S., and Watanabe, Y.: Effect of a human-type communication robot on cognitive function in elderly females living alone. Med. Sci. Monit., 18(9): CR550-557, 2012.
09.: Kawasaki, T., Marumo, T., Shirakami, K., Mori, T., Doi, H., Suzuki, M., Watanabe, Y., Chaki, S., Nakazato, A., Ago, Y., Hashimoto, H., Matsuda, T., Baba, A., and Onoe, H.: Increase of 20-HETE synthase after brain ischemia in rats revealed by PET study with (11)C-labeled 20-HETE synthase-specific inhibitor. J. Cereb. Blood Flow Metab., 32(9): 1737-1746, 2012.
10.: Kataoka, M., Takashima, T., Shingaki, T., Hashizume, Y., Katayama, Y., Wada, Y., Oh, H., Masaoka, Y., Sakuma, S., Sugiyama, Y., Yamashita, S., and Watanabe, Y.: Dynamic analysis of GI absorption and hepatic distribution processes of telmisartan in rats using positron emission tomography. Pharm. Res., 29(9): 2419-2431, 2012.
11.: Ijuin, R., Takashima, T., Watanabe, Y., Sugiyama, Y., and Suzuki, M.: Synthesis of [(11)C]dehydropravastatin, a PET probe potentially useful for studying OATP1B1 and MRP2 transporters in the liver. Bioorg. Med. Chem., 20(12): 3703-3709, 2012.
12.: Mizuno, K., Tanaka, M., Tanabe, H. C., Sadato, N., and Watanabe, Y.: The neural substrates associated with attentional resources and difficulty of concurrent processing of the two verbal tasks. Neuropsychologia, 50(8): 1998-2009, 2012.
13.: Shigihara, Y., Tanaka, M., Mizuno, K., Ishii, A., Yamano, E., Funakura, M., Kanai, E., and Watanabe, Y.: Effects of daily levels of fatigue and acutely induced fatigue on the visual evoked magnetic response. Brain Res., 1457: 44-50, 2012.
14.: Tanaka, M., Shigihara, Y., Funakura, M., Kanai, E., and Watanabe, Y.: Fatigue-associated alterations of cognitive function and electroencephalographic power densities. PLoS One, 7(4): e34774, 2012.
15.: Ishii, A., Tanaka, M., Yamano, E., and Watanabe, Y.: Neural substrates activated by viewing others expressing fatigue: A magnetoencephalography study. Brain Res., 1455: 68-74, 2012.
16.: Takashima, T., Kitamura, S., Wada, Y., Tanaka, M., Shigihara, Y., Ishii, H., Ijuin, R., Shiomi, S., Nakae, T., Watanabe, Yu., Cui, Y., Doi, H., Suzuki, M., Maeda, K., Kusuara, H., Sugiyama, Y., and Watanabe, Y.: PET Imaging-Based Evaluation of Hepatobiliary Transport in Humans with (15R)-11C-TIC-Me. J. Nucl. Med., 53(5): 741-748, 2012.
17.: Shimizu, K., Takashima, T., Yamane, T., Sasaki, M., Kageyama, H., Hashizume, Y., Maeda, K., Sugiyama, Y., Watanabe, Y., and Senda, M.: Whole-body distribution and radiation dosimetry of [(11)C]telmisartan as a biomarker for hepatic organic anion transporting polypeptide (OATP) 1B3. Nucl. Med. Biol., 39(6): 847-853, 2012.
18.: Shingaki, T., Takashima, T., Wada, Y., Tanaka, M., Kataoka, M., Ishii, A., Shigihara, Y., Sugiyama, Y., Yamashita, S., and Watanabe, Y.: Imaging of gastrointestinal absorption and biodistribution of orally administered probe of positron emission tomography in human. Clin. Pharmacol. Ther., 91(4): 653-659, 2012.
19.: Tanaka, K., Mazumder, K., Siwu, E.R.O., Nozaki, S., Watanabe, Y., and Fukase, K.: Auxiiary-directed oxidation of ursolic acid by ‘Ru’-porphyrins: chemical modulation of cytotoxicity against tumor cell lines. Tetrahedron Lett., 53(14): 1756-1759, 2012.
20.: Tanaka, M., Yamada, H., Nakamura, T., and Watanabe, Y.: Effects of pellet stove on recovery from mental fatigue. Med. Sci. Monit., 18(3): CR148-153, 2012.
21.: Tanaka, M., and Watanabe, Y.: Risk-management syndrome. Int. J. Psychiatry Clin. Pract., 16(4): 312-315, 2012.
22.: Kuratsune, D., Tajima. S., Koizumi, J., Yamaguti, K., Sasabe, T., Mizuno, K., Tanaka, M., Okawa, N., Mito, H., Tsubone, H., Watanabe, Y., Inoue, M., and Kuratsune, H.: Changes in reaction time, coefficient of variance of reaction time, and autonomic nerve function in the mental fatigue state caused by long-term computerized Kraepelin test workload in healthy volunteers. World Journal of Neuroscience, 2: 113-118, 2012.
23.: Shimazawa, M., Ito, Y., Inokuchi, Y., Yamanaka, H., Nakanishi, T., Hayashi, T., Ji, B., Higuchi, M., Suhara, T., Imamura, K., Araie, M., Watanabe, Y., Onoe, H., and Hara H.: An alteration in the lateral geniculate nucleus of experimental glaucoma monkeys: In vivo positron emission tomography imaging of glial activation. PLoS One, 7(1):e30526, 2012.
24.: Ose, T., Watabe, H., Hayashi, T., Kudomi, N., Hikake, M., Fukuda, H., Teramoto, N., Watanabe, Y., Onoe, H., and Iida, H.: Quantification of regional cerebral blood flow in rats using an arteriovenous shunt and micro-PET. Nucl. Med. Biol., 39(5): 730-741, 2012.
25.: Tanaka, K., Shirotsuki, S., Iwata, T., Kageyama, C., Tahara, T., Nozaki, S., Siwu, E.R.O., Tamura, S., Douke, S., Murakami, N., Onoe, H., Watanabe, Y., and Fukase, K.: Template-assisted and self-activating clicked peptide as a synthetic mimic of the SH2 domain. ACS Chem. Biol., 7(4): 637-635, 2012.
26.: Yashio, K., Katayama, Y., Takashima, T., Ishiguro, N., Doi, H., Suzuki, M., Wada, Y., Tamai, I., and Watanabe, Y.: Synthesis of [11C]uric acid, using [11C]phosgene, as a possible biomarker in PET imaging for diagnosis of gout. Bioorg. Med. Chem. Lett., 22(1): 115-119, 2012.
27.: Tanaka, M., and Watanabe, Y.: Supraspinal regulation of physical fatigue. Neurosci. Biobehav. Rev., 36(1): 727-734, 2012.
28.: Yamakawa, Y., Shimada, H., Ataka, S., Tamura, A., Masaki, H., Naka, H., Tsutada, T., Nakanishi, A., Shiomi, S., Watanabe, Y., and Miki, T.: Two cases of dementias with motor neuron disease evaluated by Pittsburgh compound B-positron emission tomography. Neurol. Sci., 33(1): 87-92, 2012.

2011年

01.: Kyono, K., Takashima, T., Katayama, Y., Kawasaki,T., Zochi, R., Gouda, M., Kuwahara, Y., Takahashi, K., Wada, Y., Onoe, H., and Watanabe, Y.: Use of [18F]FDOPA-PET for in vivo evaluation of dopaminergic dysfunction in unilaterally 6-OHDA-lesioned rats. EJNMMI Res., 1(1): 25, 2011.
02.: Ozawa, M., Takahashi, K., Akazawa, K., Takashima, T., Nagata, H., Doi, H., Hosoya, T., Wada, Y., Cui, Y.L., Kataoka, Y., and Watanabe, Y.: Positron emission tomography imaging of aromatase in gastric parietal cells using [11C]Vorozole. J. Nucl. Med., 52(12): 1964-1969, 2011.
03.: Tanaka, M., Mizuno, K., Yamaguti, K., Kuratsune, H., Fujii, A., Baba, H., Matsuda, K.,Nishimae, A., Takesaka, T., and Watanabe, Y.: Autonomic nervous alterations associated with daily level of fatigue. Behav. Brain. Funct., 7(1): 46, 2011.
04.: Takashima, T., Hashizume, Y., Katayama, Y., Murai, M., Wada, Y., Maeda, K., Sugiyama, Y., and Watanabe, Y.: The involvement of organic anion transporting polypeptide in the hepatic uptake of telmisartan in rats: PET studies with 11C telmisartan. Mol. Pharm., 8(5): 1789-1798, 2011.
05.: Mazumder, K., Siwu, E.R.O., Nozaki, S., Watanabe, Y., Tanaka, K., and Fukase, K.: Ursolic acid derivatives from Bangladeshi medicinal plant, Saurauja roxburghii: Isolation and cytotoxic activity against A431 and C6 glioma cell lines. Phytochem. Lett., 4(3): 287-291, 2011.
06.: Tanaka, M., Shigihara, Y., and Watanabe, Y.: Central inhibition regulates motor output during physical fatigue. Brain Res., 1412: 37-43, 2011.
07.: Kobayashi, M., Sasabe, T., Shigihara, Y., Tanaka, M., and Watanabe, Y.: Gustatory imagery reveals functional connectivity from the prefrontal to insular cortices traced with magnetoencephalography. PLoS One, 6(7): e21736, 2011.
08.: Shimada, H., Ataka, S., Takeuchi, J., Mori, H., Wada, Y., Watanabe, Y., and Miki, T.: Pittsburgh Compound B-Negative Dementia--A Possibility of Misdiagnosis of Patients With Non-Alzheimer Disease-Type Dementia as Having AD. J Geriatr. Psychiatry Neurol., 24(3): 123-126, 2011.
09.: Shukuri, M., Takashima-Hirano, M., Tokuda, K., Takashima, T., Matsumura, K., Inoue, O., Doi, H., Suzuki, M., Watanabe, Y., and Onoe, H.: In vivo expression of cyclooxygenase-1 in activated microglia/macrophages during neuroinflammation visualized by PET with 11C-Ketoprofen-methyl ester. J. Nucl. Med., 52(7): 1094-1101, 2011.
10.: Mizuno, K., Tanaka, M., Fukuda, S.,Yamano, E., Shigihara, Y., Imai-Matsumura, K., and Watanabe, Y.: Low visual information-processing speed and attention are predictors of fatigue in elementary and junior high school students. Behav. Brain Funct., 7(1):20, 2011.
11.: Mizuno, K., Tanaka, M., Yamaguti, K., Kajimoto, O, Kuratsune, H., and Watanabe, Y.: Mental fatigue caused by prolonged cognitive load associated with sympathetic hyperactivity. Behav. Brain Funct., 7(1):17, 2011.
12.: Takashima, T., Yokoyama, C., Mizuma, H., Yamanaka, H., Wada, Y., Onoe, K., Nagata, H., Tazawa, S., Doi, H., Takahashi, K., Morita, M., Kanai, M., Shibasaki, M., Kusuhara, H., Sugiyama, Y., Onoe, H., and Watanabe, Y.: Developmental Changes in P-glycoprotein Function in the Blood-Brain Barrier of Non-Human Primates: PET Study with R-[11C] Verapamil and [11C] Oseltamivir. J. Nucl. Med., 52(6): 950-957, 2011.
13.: Tanaka, M., and Watanabe, Y.: Neural compensation mechanisms to regulate motor output during physical fatigue. Brain Res., 1395: 46-52, 2011.
14.: Tsutsumi, K., Tanaka, M., Shigihara, Y., and Watanabe, Y.: Central regulation of physical fatigue via mirror visual feedback. Eur. J. Sport Sci., 11(3): 171-175, 2011.
15.: Kawatani, J., Mizuno, K., Shiraishi, S., Takano, M., Joudoi, T., Fukuda, S., Watanabe, Y., and Tomoda, A.: Cognitive dysfunction and mental fatigue in childhood chronic fatigue syndrome -- a 6-month follow-up study. Brain Dev., 33(10): 832-841, 2011.
16.: Takashima-Hirano, M., Takashima, T., Katayama, Y., Wada, Y., Sugiyama, Y., Watanabe, Y., Doi, H., and Suzuki, M.: Efficient sequential synthesis of PET probes of COX-2 inhibitor　[11C]Celecoxib and its major metabolite [11C]SC-62807 and in vivo behavior　evaluation by positron emission tomography. Bioorg Med Chem., 19(9): 2997-3004, 2011.
17.: Takahashi, K., Onoe, K., Doi, H., Nagata, H., Yamagishi, G., Hosoya, T., Tamura, Y., Wada, Y., Yamanaka, H., Yokoyama, C., Mizuma, H., Takashima, T., Bergström, M., Onoe, H., Långström, B., and Watanabe, Y. : Increase in hypothalamic aromatase in macaque monkeys treated with anabolic androgenic steroids: PET study with [11C]vorozole. Neuroreport, 22(7): 326-330, 2011.
18.: Fukuchi, T., Arai, Y., Watanabe, F., Motomura, S., Takeda, S., Kanayama, Y., Haba, H., Watanabe, Y., and Enomoto, S.: A digital signal processing module for Ge semiconductor detectors. IEEE Trans. Nucl. Sci., 58(2): 461-467, 2011.
19.: Iimori, H., Hashizume, Y., Sasaki, M., Kajiwara, Y., Sugimoto, Y., Sugiyama, Y., Watanabe, Y., and Senda, M.: First automatic radiosynthesis of (11)C labeled Telmisartan using a multipurpose synthesizer for clinical research use. Ann. Nucl. Med., 25(5) 333-337, 2011.
20.: Takahashi, K., Yamagishi, G., Hiramatsu, T., Hosoya, A., Onoe, K., Doi, H., Nagata, H., Wada, Y., Onoe, H., Watanabe, Y., and Hosoya, T.: Practical synthesis of precursor of [N-methyl-11C]vorozole, an efficient PET tracer targeting aromatase in the brain. Bioorg. Med. Chem., 19(4): 1464-1470, 2011.
21.: Ito, Y., Shimazawa, M., Inokuchi, Y., Yamanaka, H., Tsuruma, K., Imamura, K., Onoe, H., Watanabe, Y., Aihara, M., Araie, M., and Hara, H.: Involvement of endoplasmic reticulum stress on neuronal cell death in the lateral geniculate nucleus in the monkey glaucoma model. Eur. J. Neurosci., 33(5): 843-855, 2011.
22.: Mizuno, K., Tanaka, M., Fukuda, S., Imai-Matsumura, K, and Watanabe, Y.: Relationship between cognitive function and prevalence of decrease in intrinsic academic motivation in adolescents. Behav. Brain Funct., 7: 4, 2011.
23.: Yamashita, S., Takashima, T., Kataoka, M., Oh, H., Sakuma, S., Takahashi, M., Suzuki, N., Hayashinaka, E., Wada, Y., Cui, Y., and Watanabe, Y.: PET Imaging of the Gastrointestinal Absorption of Orally Administered Drugs in Conscious and Anesthetized Rats. J. Nucl. Med., 52(2): 249-56, 2011.
24.: Kuboyama, T., Nakahara, M., Yoshino, M., Cui, Y.L., Sako, T., Wada, Y., Imanishi, T., Obika, S., Watanabe, Y., Suzuki, M., and Doi, H.: Stoichiometry-focused 18F-labeling of alkyne-substituted oligodeoxynucleotides using azido([18f]fluoromethyl)benzenes by Cu-catalyzed Huisgen reation. Bioorg. Med. Chem., 19(1): 249-255, 2011.
25.: Mizuno, K., Tanaka, M., Fukuda, S., Imai-Matsumura, K, and Watanabe, Y.: Relationship between cognitive functions and prevalence of fatigue in elementary and junior high school students. Brain Dev., 33(6):470-479, 2011.
26.: Mizuno, K., Tanaka, M., Fukuda, S., Sasabe, T., Imai-Matsumura, K., and Watanabe, Y.: Changes in cognitive functions of students in the transitional period from elementary school to junior high school. Brain Dev., 33(5): 412-420, 2011.

2010年

01.: Tanaka, K., Minami, K., Tahara, T., Fujii, Y., Siwu, E.R.O., Koyama, K., Nozaki, S., Onoe, H., Watanabe, Y., and Fukase, K.: A combined 6π-azaelectrocyclization/ staudinger approach to protein and cell engineering: non-invasive tumor targeting by N-glycan-engineered lymphocytes. J. Carbohydrate Chem., 29(3): 118-132, 2010.
02.: Tajima, S., Yamamoto, S., Tanaka, M., Kataoka, Y., Iwase, M., Yoshikawa, E., Okada, H., Onoe, H., Tsukada, H., Kuratsune, H., Ouchi, Y., and Watanabe, Y.: Medial orbitofrontal cortex is associated with fatigue sensation. Neurol. Res. Int., 2010:671421, 2010.
03.: Tanaka, K., Siwu, E.R.O., Minami, K., Hasegawa, K., Nozaki, S., Kanayama, Y., Koyama, K., Chen, W. C., Paulson, J. C., Watanabe, Y., and Fukase, K.: Non-invasive imaging of dendrimer-type N-Glycan clusters: Remarkable in vivo dynamics dependence on oligosaccharide structure. Angew. Chem. Int. Ed., 49(44): 8195-9200, 2010.
04.: Shigihara, Y., Tanaka, M., Watanabe, Y.: Relationship between fatigue and photosensitivity. Behav. Med., 36(4): 109-112, 2010.
05.: Shishioh-Ikejima, N., Ogawa, T., Yamaguti, K., Watanabe, Y., Kuratsune, H., and Kiyama, H.: The increase of alpha-melanocyte-stimulating hormone in the plasma of chronic fatigue syndrome patients. BMC Neurol., 10:73, 2010.
06.: Katsuyama, N., Imamura, K., Onoe, H., Tanaka, H.K., Onoe, K., Tsukada, H., and Watanabe, Y.: Cortical activation during color discrimination task in macaques as revealed by positron emission tomography. Neurosci. Lett., 484(3): 168-173, 2010.
07.: Takashima, T., Nagata, H., Nakae, T., Cui, Y., Wada, Y., Kitamura, S., Doi, H., Suzuki, M., Maeda, K., Kusuhara, H., Sugiyama, Y., and Watanabe, Y.: PET studies using 15R-[11C]TIC-Me for the evaluation of hepatobiliary transport.J. Pharmacol. Exp. Ther., 335(2): 314-323, 2010.
08.: Mizuma, H., Shukuri, M., Hayashi, T., Watanabe, Y., and Onoe, H.: Establishment of in vivo brain imaging method in mice under conscious condition. J. Nucl. Med., 51(7): 1068-1075, 2010.
09.: Tanaka, M., Mizuno, K., Fukuda, S., and Watanabe, Y.: Personality and fatigue in medical students. Psycol. Rep., 106(2): 567-575, 2010.
10.: Fukuda, S., Yamano, E., Joudoi, T., Mizuno, K., Tanaka, M., Kawatani, J., Takano, M., Akemi, T., Imai-Matsumura, K., Miike, T., and Watanabe, Y.: Effort-reward imbalance for learning is associated with fatigue in school children. Behav. Med., 36(2): 53-62, 2010.
11.: Kamei, N., Morishita, M., Kanayama, Y., Hasegawa, K., Nishimura, M., Hayashinaka, E., Wada, Y., Watanabe, Y., and Takayama K.: Molecular imaging analysis of intestinal insulin absorption boosted by cell-penetrating peptides by using positron emission tomography. J. Control. Release, 146(1): 16-22, 2010.
12.: Tanaka, K., Minami, K., Tahara, T., Fujii, Y., Siwu, E.R., Nozaki, S., Onoe, H., Yokoi, S., Koyama, K., Watanabe, Y., and Fukase, K.: Electrocyclization-based labeling allows efficient in vivo imaging of cellular trafficking. Chem. Med. Chem., 5(6): 841-845, 2010.
13.: Yamano, E., Fukuda, S., Jodoi, T., Mizuno, K., Tanaka, M., Kataoka, Y., Kawatani, J., Takano, M., Tomoda, A., Imai-Matsumura, K., Miike, T., Matsuda, F., and Watanabe, Y.: Temperament and character as predictors of fatigue-induced symptoms among school children in Japan: A 1-year follow-up study. Compr. Psychiatry, 51(3): 256-265, 2010.
14.: Tanaka, M., and Watanabe, Y.: A new hypothesis of chronic fatigue syndrome: co-conditioning theory. Med. Hypotheses, 75(2): 244-249, 2010.
15.: Shimizu, T., Hoshino, H., Nishi, S., Nozaki, S., and Watanabe, Y.: Anti-fatigue effect of dicethiamine hydrochloride is likely associated with excellent absorbability and highly transformability in tissues as a vitamin B(1). Eur. J. Pharmacol., 635(1-3): 117-123, 2010.
16.: Fukuda, S., Hashimoto, R., Ohi, K., Yamaguti, K., Nakatomi, Y., Yasuda, Y., Kamino, K., Takeda, M., Tajima, S., Kuratsune, H., Nishizawa, Y., and Watanabe, Y.: A functional polymorphism in the Disrupted-in schizophrenia gene is associated with chronic fatigue syndrome. Life Sciences, 86(19-20): 722-725, 201.
17.: Takashima-Hirano, M., Shukuri, M., Takashima, T., Goto, M., Wada, Y., Watanabe, Y., Onoe, H., Doi, H., and Suzuki, M.: General Method for the (11)C-Labeling of 2-Arylpropionic Acids and Their Esters: Construction of a PET Tracer Library for a Study of Biological Events Involved in COXs Expression. Chemistry, 16(14):4250-4258, 2010.
18.: Koyama, H., Fukuda, S., Shoji, T., Inaba, M., Tsujimoto, Y., Tabata, T., Okuno, S., Yamakawa, T., Okada, S., Okamura, M., Kuratsune, H., Fujii, H., Hirayama, Y., Watanabe, Y., and Nishizawa, Y.: Fatigue is a predictor for cardiovascular outcomes in patients undergoing hemodialysis. Clin. J. Am. Soc. Nephrol., 5(4): 659-666, 2010.
19.: Shigihara, Y., Tanaka, M., Tsuyuguchi, N., Tanaka, H., and Watanabe, Y.: Hazardous nature of high-temporal-frequency strobe light stimulation: neural mechanisms revealed by magnetoencephalography. Neuroscience, 166(2): 482-490, 2010.
20.: Mizuno, K., Tanaka, M., Tajima, K., Okada, N., Rokushima, K., and Watanabe, Y.: Effects of mild-stream bathing on recovery from mental fatigue. Med. Sci. Monit., 16(1): CR8-14, 2010.
21.: Akazawa, K.H., Cui, Y.L., Tanaka, M., Kataoka, Y., Yoneda, Y., and Watanabe, Y.: Mapping of regional brain activation in response to fatigue-load and recovery in rats with c-Fos immunohistochemistry. Neurosci. Res., 66(4): 372-379, 2010.