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業績紹介

平成29年（2017年）の業績一覧

著書：和文

著書、学術論文等の名称 発表 発行所、発表雑誌等の名称 著者名
機能性ディスペプシア 2018 今日の治療指針　P470-472 藤原靖弘
胃食道逆流症 2018 診療ガイドラインUp-to-date2018-19　P227-230 藤原靖弘
胃食道逆流症 2017 朝倉内科学　P898-901 藤原靖弘
逆流性食道炎 2017 診断と治療　増刊号　これ一冊でわかる消化器　診断基準と分類法　p23-26 沢田明也、藤原靖弘
336専門家による～私の治療～2017年―2018年版 胃十二指腸潰瘍 2017 日本医事新報社,総ページ数1734頁、当部分：p372-373 渡辺俊雄、荒川哲男

原著論文：和文

著書、学術論文等の名称 発表 発行所、発表雑誌等の名称 著者名
1. 小麦蛋白のグリアジンはNSAID起因性小腸粘膜傷害の増悪因子である 2018 潰瘍 第45巻 (in press) 島田直、谷川徹也、灘谷祐二、大谷恒史、渡辺俊雄、藤原靖弘
2. 細径内視鏡を用いた当院人間ドックにおける胃がん標準化発見比の検討. 2017 人間ドック. 2017;32(3):537-543. 田中史生、福本真也、森川浩安、木村達郎、中野朱美、大谷恒史、森崎珠実、藤原靖弘、河田則文、平田一人
3. NLRP3インフラマソーム活性化阻害薬としてのコルヒチンーNSAIDs起因性小腸傷害の治療薬としての可能性― 2017 潰瘍44, 44-47 渡辺俊雄、大谷恒史、灘谷祐二、谷川徹也、富永和作、藤原靖弘、荒川哲男
4. 生薬甘草有効成分イソリクイリチゲニンはインフラマソーム活性化阻害作用を介して非ステロイド系抗炎症薬起因性小腸傷害を抑制する 2017 潰瘍 44巻 Page68-71 谷川徹也、渡辺俊雄、灘谷祐二、大谷恒史、荒川哲男、藤原靖弘
5. 中国（香港を含む）におけるHelicobacter pylori除菌による胃がん予防 2017 Helicobacter Research 21 (4): 336-340, 2017. 大谷恒史、渡辺俊雄、藤原靖弘

原著論文：欧文

著書、学術論文等の名称 発表 発行所、発表雑誌等の名称 著者名
1. Usefulness of small bowel reexamination in obscure gastrointestinal bleeding patients with negative capsule endoscopy findings: comparison of repeat capsule endoscopy and double-balloon enteroscopy 2018 United European Gastroenterol J. 2018 (in press) Otani K, Watanabe T, Shimada S, Nadatani Y, Hosomi S, Nagami Y, Tanaka F, Kamata N, Taira K, Yamagami H, Tanigawa T, Shiba M, Fujiwara Y.
2. Combined infection of human herpes viruses: a risk factor for subsequent colectomy in ulcerative colitis 2018 Inflamm Bowel Dis. In press Hosomi S, Watanabe K, Nishida Y, Yamagami H, Yukawa T, Otani K, Nagami Y, Tanaka F, Taira K, Kamata N, Tanigawa T, Shiba M, Watanabe T, Nagahara H, Maeda K, Fujiwara Y
3. Does discontinuation of antithrombotics affect the diagnostic yield of small bowel capsule endoscopy in patients demonstrating obscure gastrointestinal bleeding? 2018 J Clin Biochem Nutr., in press Nakamura S, Watanabe T, Shimada S, Nadatani Y, Otani K, Tanigawa T, Miyazaki T, Iimuro M and Fujiwara Y
4. Efficacy of a concomitant elemental diet to reduce the loss of response to adalimumab in patients with intractable Crohn's disease. 2018 J Gastroenterol Hepatol. 2018 Mar;33(3):631-637. Sugita N, Watanabe K, Kamata N, Yukawa T, Otani K, Hosomi S, Nagami Y, Tanaka
F, Taira K, Yamagami H, Tanigawa T, Shiba M, Watanabe T, Tominaga K, Kabata D,Shintani A, Arakawa T, Fujiwara Y.
5. A phase II trial of capecitabine plus cisplatin (XP) for patients with advanced gastric cancer with early relapse after S-1 adjuvant therapy: XParTS-I trial. 2018 Gastric Cancer. 2018 Feb 27. doi: 10.1007/s10120-018-0815-0. Nishikawa K, Tsuburaya A, Yoshikawa T, Takahashi M, Tanabe K, Yamaguchi K, Yoshino S, Namikawa T, Aoyama T, Rino Y, Kawada J, Tsuji A, Taira K, Kimura Y, Kodera Y, Hirashima Y, Yabusaki H, Hirabayashi N, Fujitani K, Miyashita Y, Morita S, Sakamoto J.
6. The feasibility and short-term clinical outcomes of single-incision laparoscopic surgery for patients with complex Crohn's disease. 2018 Surg Today. 2018 Feb;48(2):242-247. Maeda K, Nagahara H, Shibutani M, Fukuoka T, Nakao S, Yamagami H, Kamata N, Muguruma K, Tanaka H, Toyokawa T, Hirakawa K, Ohira M.
7. Forkhead box F2 suppresses gastric cancer through a novel FOXF2-IRF2BPL-β-catenin signaling axis. 2018 Cancer Res. 2018 Jan 26 pii: canres.2403.2017. Higashimori A, Dong Y, Zhang Y, Kang W, Nakatsu G, Ng SS, Arakawa T, Sung JJ, Chan FK, Yu J.
8. Isoliquiritigenin Ameliorates Indomethacin-Induced Small Intestinal Damage by Inhibiting NOD-Like Receptor Family, Pyrin Domain-Containing 3 Inflammasome Activation. 2018 Pharmacology. 2018 Jan 26;101(5-6):236-245. Nakamura S, Watanabe T, Tanigawa T, Shimada S, Nadatani Y, Miyazaki T, Iimuro M, Fujiwara Y.
9. Sepsis Markers Soluble IL-2 Receptor and Soluble CD14 Subtype as Potential Biomarkers for Complete Mucosal Healing in Patients With Inflammatory Bowel Disease. 2018 J Crohns Colitis.2018 Jan 5;12(1):87-95 Hosomi S, Yamagami H, Itani S, Yukawa T, Otani K, Nagami Y, Tanaka F, Taira K,
Kamata N, Tanigawa T, Shiba M, Watanabe T, Fujiwara Y
10. Risk of pancreatitis after pancreatic duct guidewire placement during endoscopic retrograde cholangiopancreatography. 2018 PLoS One. 2018 Jan
10;13(1):e0190379.		 Ishikawa-Kakiya Y, Shiba M, Maruyama H, Kato K, Fukunaga S, Sugimori S, Otani
K, Hosomi S, Tanaka F, Nagami Y, Taira K, Yamagami H, Tanigawa T, Watanabe T,
Fujiwara Y.
11. Clinical features of chronic enteropathy associated with SLCO2A1 gene: a new entity clinically distinct from Crohn's disease. 2018 J Gastroenterol. 2018 Jan 8
doi: 10.1007/s00535-017-1426-y. [Epub ahead of print]		 Umeno J, Esaki M, Hirano A, Fuyuno Y, Ohmiya N, Yasukawa S, Hirai F, Kochi S, Kurahara K, Yanai S, Uchida K, Hosomi S, Watanabe K, Hosoe N, Ogata H, Hisamatsu T, Nagayama M, Yamamoto H, Abukawa D, Kakuta F, Onodera K, Matsui T, Hibi T, Yao T, Kitazono T, Matsumoto T; CEAS study group.
12. Efficacy and safety of Helicobacter pylori eradication therapy immediately after endoscopic submucosal dissection 2017 J Gastroenterol Hepatol. 2017 Dec 19. doi: 10.1111/jgh.14073. Takahashi Y, Takeuchi T, Kojima Y, Nagami Y, Ominami M, Uedo N, Hamada K, Suzuki H, Oda I, Miyaoka Y, Yamanouchi S, Tokioka S, Tomatsuri N, Yoshida N, Naito Y, Nonaka T, Kodashima S, Ogata S, Hongo Y, Oshima T, Li Z, Shibagaki K, Oikawa T, Tominaga K, Higuchi K.
13. Evaluation of an e-learning system for diagnosis of gastric lesions using magnifying narrow-band imaging: a multicenter randomized controlled study. 2017 Endoscopy. 2017. 49(10):957-967. Nakanishi H, Doyama H, Ishikawa H, Uedo N, Gotoda T, Kato M, Nagao S, Nagami Y, Aoyagi H, Imagawa A, Kodaira J, Mitsui S, Kobayashi N, Muto M, Takatori H, Abe T, Tsujii M, Watari J, Ishiyama S, Oda I, Ono H, Kaneko K, Yokoi C, Ueo T, Uchita K, Matsumoto K, Kanesaka T, Morita Y, Katsuki S, Nishikawa J, Inamura K, Kinjo T, Yamamoto K, Yoshimura D, Araki H, Kashida H, Hosokawa A, Mori H, Yamashita H, Motohashi O, Kobayashi K, Hirayama M, Kobayashi H, Endo M, Yamano H, Murakami K, Koike T, Hirasawa K, Miyaoka Y, Hamamoto H, Hikichi T, Hanabata N, Shimoda R, Hori S, Sato T, Kodashima S, Okada H, Mannami T, Yamamoto S, Niwa Y, Yashima K, Tanabe S, Satoh H, Sasaki F, Yamazato T, Ikeda Y, Nishisaki H, Nakagawa M, Matsuda A, Tamura F, Nishiyama H, Arita K, Kawasaki K, Hoppo K, Oka M, Ishihara S, Mukasa M, Minamino H, Yao K.
14. A prospective study on second-generation colon capsule endoscopy to detect mucosal lesions and disease activity in ulcerative colitis (with video). 2017 Gastrointest Endosc. 2017 Dec;86(6):1139-1146. Shi HY, Chan FKL, Higashimori A, Kyaw M, Ching JYL, Chan HCH, Chan JCH, Chan AWH, Lam KLY, Tang RSY, Wu JCY, Sung JJY, Ng SC.
15. Safety and efficacy of transpapillary bridged bilateral side-by-side stenting for unresectable malignant hilar biliary obstruction. 2017 Hepatobiliary Pancreat Dis Int. 2017 Dec 15;16(6):659-661. Maruyama H, Tominaga K, Kato K, Sugimori S, Shiba M, Watanabe T, Fujiwara Y.
16. Serum interleukin-6 level is associated with response to infliximab in ulcerative colitis 2017 Scand J Gastroenterol. 2017 Nov 24:1-7 Nishida Y, Hosomi S, Watanabe K, Watanabe K, Yukawa T, Otani K, Nagami Y,Tanaka F, Taira K, Kamata N, Yamagami H, Tanigawa T, Watanabe T, Fujiwara Y.
17. Brushing the distal biliary stricture in the surrounding of the papilla increased the risk of post-endoscopic retrograde cholangiopancreatography pancreatitis: A retrospective study using propensity score analysis. 2017 United European Gastroenterol J. 2017 Nov;5(7):1015-1023 Kato K, Sugimori S, Kakiya Y, Maruyama H, Fukunaga S, Nagami Y, Shiba M,
Tanigawa T, Watanabe T, Fujiwara Y.
18. Intestinal epithelial cell endoplasmic reticulum stress promotes MULT1 up-regulation and NKG2D-mediated inflammation. 2017 J Exp Med. 2017 Oct 2;214(10):2985-2997 Hosomi S, Grootjans J, Tschurtschenthaler M, Krupka N, Matute JD, Flak MB, Martinez-Naves E, Gomez Del Moral M, Glickman JN, Ohira M, Lanier LL, Kaser A, Blumberg R.
19. Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation. 2017 Science. 2017 Oct 20;358(6361):359-365. Atarashi K, Suda W, Luo C, Kawaguchi T, Motoo I, Narushima S, Kiguchi Y, Yasuma K, Watanabe E, Tanoue T, Thaiss CA, Sato M, Toyooka K, Said HS, Yamagami H, Rice SA, Gevers D, Johnson RC, Segre JA, Chen K, Kolls JK, Elinav E, Morita H, Xavier RJ, Hattori M, Honda K.
20. Chronic Enteropathy Associated With SLCO2A1 Gene [CEAS]-Characterisation of an Enteric Disorder to be Considered in the Differential Diagnosis of Crohn's Disease. 2017 J Crohns Colitis. 2017 Oct 1;11(10):1277-1281 Hosoe N, Ohmiya N, Hirai F, Umeno J, Esaki M, Yamagami H, Onodera K, Bamba S, Imaeda H, Yanai S, Hisamatsu T, Ogata H, Matsumoto T; CEAS Atlas Group.
21. Accuracy of Faecal Immunochemical Test to Predict Endoscopic and Histological Healing in Ulcerative Colitis: A Prospective Study Based on Validated Histological Scores. 2017 J Crohns Colitis. 2017 Sep 1;11(9):1071-1077 Shi HY, Chan FKL, Chan AWH, Higashimori A, Kyaw M, Ching JYL, Luk AKC, Wong SH, Wu JCY, Sung JJY, Ng SC.
22. Prediction of esophageal stricture in patients given locoregional triamcinolone injections immediately after endoscopic submucosal dissection. 2017 Dig Endosc. 2018 Mar;30(2):198-205. Nagami Y, Ominami M, Shiba M, Sakai T, Fukunaga S, Sugimori S, Otani K, Hosomi
S, Tanaka F, Taira K, Kamata N, Yamagami H, Tanigawa T, Watanabe T, Ishihara T,
Yamamoto K, Fujiwara Y.
1. Prediction of esophageal stricture in patients given locoregional triamcinolone injections immediately after endoscopic submucosal dissection.
2. Analysis of the Risk Factors of Surgery after Endoscopic Balloon Dilation for Small Intestinal Strictures in Crohn's Disease Using Double-balloon Endoscopy		 2017 Intern Med. 2017 Sep 1;56(17):2245-2252. Nishida Y, Hosomi S, Yamagami H, Yukawa T, Nagami Y, Tanaka F, Kamata N, Tanigawa T, Shiba M, Watanabe T, Tominaga K, Fujiwara Y, Arakawa T.
24. Expression of Serum Exosomal and Esophageal MicroRNA in Rat Reflux Esophagitis 2017 Int J Mol Sci. 2017 Jul 25;18(8). pii: E1611 Uemura R, Murakami Y, Hashimoto A, Sawada A, Otani K, Taira K, Hosomi S,
Nagami Y, Tanaka F, Kamata N, Yamagami H, Tanigawa T, Watanabe T, Taguchi YH,
Fujiwara Y
25. Celecoxib Oral Administration for Prevention of Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis: A Randomized Prospective Trial. 2017 Pancreas. 2017 Aug;46(7):880-886. Kato K, Shiba M, Kakiya Y, Maruyama H, Ominami M, Fukunaga S, Sugimori S, Nagami Y, Watanabe T, Tominaga K, Fujiwara Y.
26. Clinical factors associated with positive capsule endoscopy findings in patients with obscure gastrointestinal bleeding: a single-center study. 2017 Scand J Gastroenterol. 2017 Nov;52(11):1219-1223. Shimada S, Watanabe T, Nadatani Y, Otani K, Taira K, Hosomi S, Nagami Y,
Tanaka F, Kamata N, Yamagami H, Tanigawa T, Shiba M, Fujiwara Y.
27. Postprandial Symptoms Felt at the Lower Part of the Epigastrium and a Possible Association of Pancreatic Exocrine Dysfunction with the Pathogenesis of Functional Dyspepsia. 2017 Intern Med. 2017;56(13):1629-1635 Fujikawa Y, Tominaga K, Tanaka F, Kamata N, Yamagami H, Tanigawa T, Watanabe
T, Fujiwara Y, Arakawa T.
28. Comparison of propofol with midazolam in endoscopic submucosal dissection for esophageal squamous cell carcinoma: a randomized controlled trial 2017 J Gastroenterol. 2017 Jun 9. Ominami M, Nagami Y, Shiba M, Tominaga K, Sakai T, Maruyama H, Kato K,
Minamino H, Fukunaga S, Tanaka F, Sugimori S, Kamata N, Machida H, Yamagami H,
Tanigawa T, Watanabe T, Fujiwara Y, Arakawa T.
29. Single Locoregional Triamcinolone Injection Immediately After Esophageal Endoscopic Submucosal Dissection Prevents Stricture Formation 2017 Clin Transl Gastroenterol. 2017 Feb 23;8(2):e75. Nagami Y, Shiba M, Ominami M, Sakai T, Minamino H, Fukunaga S, Sugimori S, Tanaka F, Kamata N, Tanigawa T, Yamagami H, Watanabe T, Tominaga K, Fujiwara Y,Arakawa T.
30. A comparison of short-term therapeutic efficacy between infliximab and tacrolimus for moderate to severe ulcerative colitis. 2017 Rom J Intern Med. 2017 Sep 26;55(3):151-157 Yamagami H, Nishida Y, Nagami Y, Hosomi S, Yukawa T, Otani K, Tanaka F, Taira
K, Kamata N, Tanigawa T, Shiba M, Watanabe T, Fujiwara Y.
31. The five-year survival rate after endoscopic submucosal dissection for superficial esophageal squamous cell neoplasia. 2017 Dig Liver Dis. 2017 Apr;49(4):427-433. Nagami Y, Ominami M, Shiba M, Minamino H, Fukunaga S, Kameda N, Sugimori S,
Machida H, Tanigawa T, Yamagami H, Watanabe T, Tominaga K, Fujiwara Y, Arakawa T.
32. Fecal Bacteria Act as Novel Biomarkers for Noninvasive Diagnosis of Colorectal Cancer. 2017 Clin Cancer Res. 2017 Apr 15;23(8):2061-2070 Liang Q, Chiu J, Chen Y, Huang Y, Higashimori A, Fang J, Brim H, Ashktorab H, Ng SC, Ng SSM, Zheng S, Chan FKL, Sung JJY, Yu J.

総説：和文

著書、学術論文等の名称 発表 発行所、発表雑誌等の名称 著者名
1. NSAIDs/アスピリン起因性小腸傷害と腸内細菌 2018 医学のあゆみ Vol 264 No1 2018.1.6 59-64 灘谷 祐二、藤原 靖弘
2. 特集　GERD診療2018-現状と課題　GERDの疫学 2018 臨床消化器内 33巻3号 Page259-264 (2018) 沢田明也、藤原靖弘
3. 好酸球性食道炎の治療 2018 胃と腸53：317-22 藤原靖弘、橋本篤
4. 難治性慢性下痢症としてのグルテン関連疾患 2018 診断と治療 第106巻 7号 (平成30年7月 in press) 島田直、谷川徹也、藤原靖弘
5. 特集　消化管治療薬　外来での使いどころ　プロスタグランジン製剤および防御因子増強薬 2018 臨床雑誌　内科
2018;121(2):241-244		 谷川徹也、渡辺俊雄、藤原靖弘
6. 特集：日本ヘリコバクター学会主導の全国除菌レジストリー（登録調査） 2018 Helicobacter Research 22: 42-47 渡辺俊雄
7. 特集　腸内細菌研究の最前線：腸内細菌とＮＳＡＩＤｓ 2017 PROGRESS IN MEDICINE, 37 (6): 681-685 渡辺俊雄、東森啓、灘谷祐二、大谷恒史、谷川徹也、藤原靖弘
8. 【上部消化管疾患trends & topics 2018】 GERD診療ガイドラインの検証と課題 2017 Mebio 34巻12号 Page20-26 (2017.12) 沢田明也、藤原靖弘
9. 特集：プロバイオティクス。NSAIDs起因性小腸傷害の病態とプロバイオティクスの活用 2017 薬局　68: 91-95, 渡辺俊雄、谷川徹也、灘谷祐二、大谷恒史、藤原靖弘
10. NSAID起因性小腸傷害の現状と対策 2017 臨床リウマチ29 (2), 77-84, 2017. 大谷恒史、渡辺俊雄、藤原靖弘
11. 消化管の慢性炎症：胃食道逆流症 2017 BIO Clinica　6：14-18 藤原靖弘
12. GERD疫学ー最近の動向 2017 日本消化器病学会誌114：1781-1789 藤原靖弘
13. GERDの薬物治療 2017 消化器・肝臓内科2：362-368 藤原靖弘

総説：欧文

著書、学術論文等の名称 発表 発行所、発表雑誌等の名称 著者名
1. Clinical Utility of Capsule Endoscopy and Double-Balloon Enteroscopy in the Management of Obscure Gastrointestinal Bleeding. 2018 Digestion. 2018 Feb 1;97(1):52-58. Otani K, Watanabe T, Shimada S, Hosomi S, Nagami Y, Tanaka F, Kamata N, Taira K, Yamagami H, Tanigawa T, Shiba M, Fujiwara Y.
2. Endoscopic Submucosal Dissection for Adenocarcinomas of the Esophagogastric Junction. 2018 Digestion. 2018 Feb 1;97(1):38-44. Nagami Y, Ominami M, Otani K, Hosomi S, Tanaka F, Taira K, Kamata N, Yamagami H, Tanigawa T, Shiba M, Watanabe T, Fujiwara Y.

症例報告：和文

著書、学術論文等の名称 発表 発行所、発表雑誌等の名称 著者名
1. 食道アカラシアに合併した多発表在型食道癌に対しESDを施行した一例 2018 Gastroenterol Endscopy. In press 丸山紘、富永和作、坂井大志、大南雅揮、永見康明、杉森聖司、斯波将次、渡辺俊雄、藤原靖弘、荒川哲男

症例報告：欧文

著書、学術論文等の名称 発表 発行所、発表雑誌等の名称 著者名
1. Lymph node metastasis of mixed adenoneuroendocrine carcinoma after curative resection of expanded criteria for early gastric cancer 2018 Intern Med. 2018. In press. Ochiai T, Ominami M, Nagami Y, Fukunaga S, Toyokawa T, Yamagami H, Tanigawa T, Watanabe T, Ohira M, Ohsawa M, Fujiwara.
2. Use of laparoscopic bag for the endoscopic retrieval of large gastric cancer after endoscopic submucosal dissection. 2018 Am J Gastroenterol. In press. Nagami Y, Ominami M, Sawada A, Sakai T, Fukunaga S, Watanabe T, Fujiwara Y.
3. A Metastatic Gastric Tumor from Ovarian Cancer. 2017 Intern Med. 2017 Nov 1. doi:
10.2169/internalmedicine.9147-17. [Epub ahead of print]		 Kono M, Nagami Y, Ominami M, Sakai T, Fukuda T, Fukunaga S, Tanaka F, Sugimori
S, Yamagami H, Tanigawa T, Shiba M, Tominaga K, Watanabe T, Fujiwara Y, Arakawa T.
4. Distal esophageal spasm with multiple esophageal diverticula successfully treated by peroral endoscopic myotomy. 2017 Clin J Gastroenterol. 2017 Oct;10(5):442-446. Otani K, Tanaka S, Kawara F, Fujikawa J, Sawada A, Uemura R, Tanigawa T,
Watanabe T, Azuma T, Fujiwara Y.