■イミダペプチド（CBEX-Dr）配合飲料の健常者における抗疲労効果 薬理と治療 / 36(3): 199-212, 2008
田中雅彰, 鴫原良仁, 藤井比佐子, 平山佳伸, 渡辺恭良.
■イミダゾールジペプチド配合飲料の日常的な作業の中で疲労を自覚している健常者に対する継続摂取による有用性 / 第1報
清水惠一郎, 福田正博, 山本晴章.
イミダゾールジペプチド配合飲料の日常的な作業のなかで疲労を自覚している健常者に対する継続摂取による有用性（PDF：657KB）
■健常者を対象としたイミダペプチド（CBEX-Dr）配合飲料の長期摂取における安全性 薬理と治療 / 36(3): 213-224, 2008
青柳さやか, 杉野友啓, 梶本佳孝, 西谷真人.
■健常者を対象としたイミダペプチド（CBEX-Dr）配合飲料の過剰摂取における安全性 薬理と治療 / 36(3): 225-235, 2008
青柳さやか, 杉野友啓, 梶本佳孝, 西谷真人.
【論文】
■Ogawa, T., Shishioh-Ikejima, N., Konishi, H., Makino, T., Sei, H., Kiryu-Seo, S., Tanaka, M., Watanabe, Y., Kiyama, H.: Chronic stress elicits prolonged activation of -MSH secretion and subsequent degeneration of melanotropha. J Neurochem, 2009 in press.
■Mizuma, H., Tanaka, M., Nozaki, S., Mizuno, K., Tahara, T., Ataka, S., Sugino, T., Shirai, T., Kajimoto, Y., Kuratsune, H., Kajimoto, O., Watanabe, Y.: Daily oral administration of crocetin attenuates physical fatigue in human. Nutr Res, 2009 in press.
■Tanaka, M., Fukuda, S., Mizuno, K., Kuratsune, H., Watanabe, Y.: Stress and coping style are associated with severe fatigue in medical students. Behav Med, 2009 in press.
■Tanaka, M., Mizuno, K., Tajima, S., Sasabe, T., Watanabe, Y.: Central nervous system fatigue alters autonomic nerve activity. Life Sci, 84(7-8): 233-299, 2009.
■Jin, G., Kataoka, Y., Tanaka, M., Mizuma, H., Nozaki, S., Tahara, T., Mizuno, K., Yamato, M., Watanabe, Y.: Changes in plasma and tissue amino acid levels in an animal model of complex fatigue. Nutrition, 2009 in press.
■Tanaka, M., Mizuno, K., Fukuda, S., Tajima, S., Watanabe, Y.: Personality traits associated with intrinsic academic motivation in medical students. Med Educ, 43: 384-387, 2009.
■Nozaki, S., Tanaka, M., Mizuno, K., Ataka, S., Mizuma, H., Tahara, T., Sugino, T., Shirai, T., Eguchi, A., Okuyama, K., Yoshida, K., Kajimoto, Y., Kuratsune, H., Kajimoto, O., Watanabe, Y.: Mental and physical fatigue-related biochemical alterations. Nutrition, 25(1): 51-57, 2009.
■Tajima, K., Tanaka, M., Mizuno, K., Okada, N., Rokushima, K., Watanabe, Y.: Effects of bathing in micro-bubbles on recovery from moderate mental fatigue. Ergonomia, 30(2), 2008.
■Tanaka, M., Fukuda, S., Mizuno, K., Imai-Matsumura, K., Jodoi, T., Kawatani, J., Takano, M., Tomoda, A., Miike, T., Watanabe, Y.: Reliability and validity of the Japanese version of the Chalder Fatigue Scale among youth in Japan. Psychol Rep, 103: 682-690, 2008.
■Yoshida, M., Tanaka, M., Mizuno, K., Ishii, A., Nozaki, K., Urakawa, A., Cho, Y., Kataoka, Y., Watanabe, Y.: Factors influencing the academic motivation of individual college students. Int J Neurosci, 118(10): 1400-1411, 2008.
■Tanaka, M., Mizuno, K., Fukuda, S., Shigihara, Y., Watanabe, Y.: Relationships between dietary habits and the prevalence of fatigue in medical students. Nutrition, 24(10): 985-989, 2008.
■Mizuno, K., Tanaka, M., Ishii, A., Tanabe, H.C., Onoe, H., Sadato, N., Watanabe, Y.: The neural basis of academic achievement motivation. NeuroImage, 42(1): 369-378, 2008.
■Tanaka, M., Baba, Y., Kataoka, Y., Kinbara, N., Sagesaka, Y.M., Kakuda, T., Watanabe, Y.: Effects of (-)-epigallocatechin gallate in liver of an animal model of combined (physical and mental) fatigue. Nutrition, 24(6): 599-603, 2008.
■Tanaka, M., Watanabe, Y.: Reduced energy utilization in the brain is a feature of an animal model of fatigue. Int J Neurosci, 118(5): 683-692, 2008.
■Mizuno, K., Tanaka, M., Nozaki, S., Mizuma, H., Ataka, S., Tahara, T., Sugino, T., Shirai, T., Kajimoto, Y., Kuratsune, H., Kajimoto, O., Watanabe, Y.: Anti-fatigue effects of coenzyme Q10 during physical fatigue. Nutrition, 24(4): 293-299, 2008.
■Ataka, S., Tanaka, M., Nozaki, S., Mizuma, H., Mizuno, K., Tahara, T., Sugino, T., Shirai, T., Kajimoto, Y., Kuratsune, H., Kajimoto, O., Watanabe, Y.: Effects of oral administration of caffeine and D-ribose on mental fatigue. Nutrition, 24(3): 233-238, 2008.
■Ataka, S., Tanaka, M., Nozaki, S., Mizuma, H., Mizuno, K., Tahara, T., Sugino, T., Shirai, T., Kajimoto, Y., Kuratsune, H., Kajimoto, O., Watanabe, Y.: Effects of Applephenon® and ascorbic acid on physical fatigue. Nutrition, 23(5): 419-423, 2007.
■Mizuno, K., Tanaka, M., Nozaki, S., Yamaguti, K., Mizuma, H., Sasabe, T., Sugino, T., Shirai, T., Kataoka, Y., Kajimoto, Y., Kuratsune, H., Kajimoto, O., Watanabe, Y.: Mental fatigue-induced decrease in levels of several plasma amino acids. J Neural Transm, 114: 555-561, 2007.
■Tahara, T., Tanaka, M., Nozaki, S., Jin, G., Onoe, H., Watanabe, Y.: Decrease of hepatic delta-aminolevulinate dehydratase activity in an animal model of fatigue. Biochem Biophys Res Commun, 353(4): 1068-1073, 2007.
■Nozaki S, Tanaka M, Mizuno K, Ataka S, Mizuma H, Tahara T, Sugino T, Shirai T,
Eguchi A, Okuyama K, Yoshida K, Kajimoto Y, Kuratsune H, Kajimoto 0, Watanabe Y,
Mental and physical fatigue-related biochemical alterations.
Nutrition. Jan;25(l):51-7. 2009
■Nakamura S, Kobayashi M, Sugino T, Kajimoto 0, Matoba R, Matsubara K.,Effect of exercise on gene expression profile in unfractionated peripheral blood leukocytes., Biochem Biophys Res Commun.. [Epub ahead of print]
■Mizuma H, Tanaka M, Nozaki S, Mizuno K, Tahara T, Ataka S, Sugino T, Shirai T, Kajimoto Y, Kuratsune H, Kajimoto 0, Watanabe Y., Daily oral administration of crocetin attenuates physical fatigue in human subjects.,Nutr Res. 2009 Mar;29(3) : 145-50.
■Nozaki S, Tanaka M, Mizuno K, Ataka S, Mizuma H, Tahara T, Sugino T, Shirai T, Eguchi A, Okuyama K, Yoshida K, Kajimoto Y, Kuratsune H, Kajimoto 0, Watanabe Y., Mental and physical fatigue-related biochemical alterations., Nutrition, 2009; 25(1): 51-57.
■Ataka S, Tanaka M, Nozaki S, Mizuma H, Mizuno K, Tahara T, Sugino T, Shirai T, Kajimoto Y, KuratsuneH, Kajimoto 0, Watanabe Y., Effects of oral administration of caffeine and D-ribose on mental fatigue., Nutrition, 2008; 24(3): 233-238.
■Mizuno K, Tanaka M, Nozaki S, Mizuma H, Ataka S, Tahara T, Sugino T, Shirai T, Kajimoto Y, Kuratsune H, Kajimoto 0, Watanabe Y., Antifatigue effects of coenzyme Q10 during physical fatigue., Nutrition, 2008; 24(4): 293-299.
■Kajimoto 0, Development of a Method of Evaluation of Fatigue and Its Economic Impacts., Fatigue Science for Human Health, 2008; 33-46.
■Sugino T, Shirai T. Kajimoto Y, Kajimoto O. L-ornithine supplementation attenuates physical fatigue in healthy volunteer by modulating lipid and amino acid metabolism. Nutr Res. ;28(11):738-43. 2008
■Mizuno K, Tanaka M, Nozaki S, Mizuma H, Ataka S, Tahara T, Sugino T, Shirai T, Kajimoto Y, Kuratsune H, Kajimoto O, Watanabe Y. Antifatigue effects of coenzyme Q10 during physical fatigue. Nutrition. Apr;24(4):293-9. 2008
■Ataka S, Tanaka M, Nozaki S, Mizuma H, Mizuno K, Tahara T, Sugino T, Shirai T, Kajimoto Y, Kuratsune H, Kajimoto O, Watanabe Y. Effects of oral administration of caffeine and D-ribose on mental fatigue. Nutrition. Mar;24(3):233-8. 2008
■Sugino T, Aoyagi S, Shirai T, Kajimot Y, Kajimoto O., Effects of Citric Acid and L-Carnitine on Physical Fatigue,. Journal of Clinical Biochemistry and Nutrition., 2007; 41(3): 224-230.
■Ataka S, Tanaka M, Nozaki S, Mizuma H, Mizuno K, Tahara T, Sugino T, Shirai T, Kajimoto Y, Kuratsune H, Kajimoto 0, Watanabe Y., Effects of ApplephenonR and ascorbic acid on physical fatigue. .Nutrition, 2007; 23(5): 419-423.
■MizunoK, Tanaka M, Nozaki S, Yamaguti K, Mizuma H, Sasabe T, Sugino I Shirai T, Kataoka Y, Kajimaoto Y, Kuratsune H, Kajimoto O, Watanabe Y., Mental fatigue-induced decrease in levels of several plasma amino acids. J Neural Transm., 2007;114 (5) :555―61. Epub 2006 Dec 11.
■Nakahachi T, Iwase M, TakahashiH, Honaga E, SekiyamaR, Ukai S, IshiiR, IshigamiW, Kajimoto 0, YamashitaK, Hashimoto R, Tanii H, Shimizu A, Takeda M., , Discrepancy of performance among working memory-related tasks in autism spectrum disorders was caused by task characteristics, apart from working memory, which could interfere with task execution., Psychiatry Clin Neurosci.,2006;60(3) :312-8.
■Ataka S, Tanaka M, Nozaki S, Mizuma H, Mizuno K, Tahara T, Sugino T, Shirai T,Kajimoto Y, Kuratsune H, Kajimoto O, Watanabe Y.Effects of Applephenon and ascorbic acid on physical fatigue.Nutrition.May;23(5):419-23. 2007
■Mizuno K, Tanaka M, Nozaki S, Yamaguti K, Mizuma H, Sasabe T, Sugino T, Shirai T,Kataoka Y, Kajimoto Y, Kuratsune H, Kajimoto O, Watanabe Y.Mental fatigue-induced decrease in levels of several plasma amino acids.J Neural Transm.;114(5):555-61. 2007
■Sugino T, Aoyagi S. Shirai T. Kajimoto Y, Kajimoto O.Effects of Citric Acid arid l-Carnitine on Physical Fatigue.J Clin Biochem Nutr. ;41(3):224-30. 2007
■Aihara K, Kajimoto O, HirataH, Takahashi R, Nakamura Y., Effect of powdered fermented milk with Lactobacillus helveticus on subjects with high-normal blood pressure or mild hypertension.,J Am Coll Nutr., 2005;24(4):257-65
■Ishida Y, Nakamura F, Kanzato H, Sawada D, Hirata H, Nishimura A, Kajimoto O, Fujiwar aS, Clinical Effects of Lactobacillus acidophilus Strain L-92 on Perennial Allergic Rhinitis: A Double-Blind, Placebo-Controlled Study, J. Dairy Sci., 2005;88;527-533
■Yamada Y, Hosoya S, Nishimura S, Tanaka T, Kajimoto Y, Nishimura A, Kajimoto 0,2005;69(3) ;559-566
■Kajimoto 0, Kajimoto Y, Yabune M, Nakamura T, Kotani K, Suzuki Y, Nozawa A, Nagata K, Unno T, Sagesaka YM, Kakuda T, Yoshikawa T, Tea Catechins with a Galloyl Moiety Reduce Body Weight and Fat, Journal of Health Science, 2005;51 (2); 161-171
■Takahashi H, Iwase M, Nakahachi T, Sekiyama R, Tabushi K, Kajimoto 0, Shimizu A, Takeda M, Spatial working memory deficit correlates with disorganization symptoms and social functioning in schizophrenia, Psychiatry and Clinical Neurosciences, 2005;59;453-460
■Sano J, Ohki K, Higuchi T, Aihara K, Mizuno S, Kajimoto O, Nakagawa S, Kajimoto Y, Nakamura Y, Effect of Casein Hydrolysate, Prepared with Protease Derived from Aspergillus oryzae, on Subjects with High-Normal Blood Pressure or Mild Hypertension, JOURNAL OF MEDICINAL FOOD, 2005; 8 (4);423-430
■Aihara K, Kajimoto O, Hirata H, Takahashi R, Nakamura Y, Effect of Powdered Fermented Milk with Lactobacillus helveticus on Subjects with High-Normal Blood Pressure or Mild Hypertension, Journal of the American College of Nutrition, 2005;24(4) ;257-265
■Ishida Y, Nakamura F, Kanzato H, Sawada D, Hirata H, Nishimura A, Kajimoto O, Fujiwara S,Clinical effects of Lactobacillus acidophilus strain L-92 on perennial allergic rhinitis: adouble-blind,placebo-controlled study. ,J Dairy Sci., 2005:88 (2):527-33.
■Sakakibara H, Nakagawa S et al. Effects of Japanese Kelp (Kombu) on life span of benzo[a]pyrene fed mice. J Nutr Sci Vitaminol 51; 369-373. 2005.
■Matsuoka R, Masuda Y, Takeuchi A, Marushima R, Hasegawa M, Sakamoto A, HirataH, Kajimoto 0, Homma Y., A Double-blind, Placebo-Controlled Study on the Effects of Mayonnaise Containing Free Plant Sterol on Serum Cholesterol Concentration; Safety Evaluation for Normocholesterolemic and Mildly Hypercholesterolemic Japanese Subjects, JOURNAL OF 0LE0 SCIENCE, 2004;53 (2) ;79-88
■Horikoshi T, Matsue K, Takahashi T, Ishii H, Yamada K, Hayashi S, Yabune M, Murakami M, Kajimoto 0.,Objective determination of fatigue development following sun exposure using Advanced Trail Making Test, International Journal of Cosmetic Science., 2004;26;9-17
■Shimizu T, Shimizu A, Yamashita K, Iwase M, Kajimoto 0, Kawasaki T., Comparison of eye-movement patterns in schizophrenic and normal adults during examination of facial affect displays. .Percept Mot Skills., 2000;91 (3 Pt 2) : 1045-56.
■Iwase M, YamashitaK, Takahashi K, Kajimoto 0, Shimizu A, Nishikawa T, Shinosaki K, Sugita Y, Takeda M., Diminished facial expression despite the existence of pleasant emotional experience in schizophrenia. .Methods Find Exp Clin Pharmacol. 1999;21 (3) : 189-94.
■Yamamoto S, Yamamoto J, Kawasaki T, YamashitaK, Shimizu T, Kajimoto 0, Hosaka N, Kitawaki K,Shiraishi J, Shimizu A.,, A pathophysiological consideration of 21 cases of reflex epilepsy induced by higher mental activity. Jpn J Psychiatry Neurol., 1992;46 (2) :440-3.
■Koyama H, Fukuda S, Shoji T, Inaba M, Tsujimoto Y, Tabata T, Okuno S, Yamakawa T, Okada S, Okamura M, Kuratsune H, Fujii H, Hirayama Y, Watanabe Y, Nishizawa Y.)
Fatigue is a predictor for cardiovascular outcomes in patients undergoing hemodialyis.
Clinical Journal of American Society of Nephrology, Mar 3 [epub ahead of print]
■Fukuda S, Yamano E, Joudoi T, Mizuno K, Tanaka M, Kawatani J, Takano M, Akemi T,
Imai-Matsumura K, Miike T, Watanabe Y. Effort-reward imbalance for learning is
associated with fatigue in school children. Behavioral Medicine (in press).
■Fukuda S, Hashimoto R, Ohi K,Yamaguti K, Nakatomi Y, Yasuda Y, Kamino K, Takeda M, Tajima S, Kuratsune H, Nishizawa Y, Watanabe Y.A functional polymorphism in
the disrupted-in schizophrennia 1 gene is associated with chronic fatigue syndrome.
Life Sciences (in press).
■西谷真人, 白市幸茂, 大塚雅生, 青柳さやか, 杉野友啓, 梶本佳孝, 梶本修身. つつみ込む気流制御エアコンの暖房使用時における抗疲労・快適および健康維持への有用性の検討～自律神経調節作用および末梢血流改善効果等について～.
日本補完代替医療学会誌 2010, In press.
■西谷真人, 白市幸茂, 大塚雅生, 青柳さやか, 杉野友啓, 梶本佳孝, 梶本修身. つつみ込む気流制御エアコンの健常女性における健康維持および疲労に対する有用性.
日本補完代替医療学会誌6(1): 27-34, 2009.
■青柳さやか, 杉野友啓, 梶本佳孝, 西谷真人. 健常者を対象としたCBEX-Dr 配合飲料の長期摂取における安全性.
薬理と治療 36: 213-24, 2008
■青柳さやか, 杉野友啓, 梶本佳孝, 西谷真人. 健常者を対象としたCBEX-Dr 配合飲料の過剰摂取における安全性.
薬理と治療 36: 225-36, 2008.
■山越純, 下條亮, 中川聡史. 乳酸菌発酵により生産したγ-アミノ酪酸の過剰摂取時の安全性. 薬理と治療34; 711-721 2006.
■山越純, 下條亮, 中川聡史 他. γ-アミノ酪酸含有減塩しょうゆの長期摂取時の正常高値血圧者および軽症高血圧者に対する有効性および安全性の検討. 薬理と治療 34; 691-709, 2006.
■波多野健二, 林田賢治, 中川聡史 他. N-アセチルグルコサミン配合調製豆乳の変形性膝関節症に対する長期摂取時の有効性および安全性の検討. 薬理と治療 34; 149-165, 2006.
【英文書籍】
■Tanaka, M., Watanabe, Y.: Mechanism of fatigue studied in a newly developed animal model of combined (mental and physical) fatigue. Fatigue Science for Human Health. Watanabe, Y., Evengård, B., Natelson, B.H., Jason, L.A., Kuratsune, H., eds. Springer. pp 203-212, 2007年11月.
■Tanaka, M., Watanabe, Y.: Lactate is not a cause of fatigue. Fatigue Science for Human Health. Watanabe, Y., Evengård, B., Natelson, B.H., Jason, L.A., Kuratsune, H., eds. Springer. pp 213-218, 2007年11月.
【和文総説（依頼原稿）】
■過労モデル動物を用いた研究からわかってきた疲労のメカニズム、田中雅彰、医学のあゆみ Vol.228(6) 最新・疲労の科学-日本発:抗疲労・抗過労への提言、610-614頁、医歯薬出版株式会社、2009.
■ヒト脳疲労、田中雅彰、医学のあゆみ Vol.228(6) 最新・疲労の科学-日本発:抗疲労・抗過労への提言、621-625頁、医歯薬出版株式会社、2009.
■疲労の分子神経メカニズム 脳機能イメージングを用いて、田中雅彰、渡辺恭良、メディカルバイオ Vol.5(4) 特集: 疲労の科学と疲労克服、36-41頁、オーム社、2008.
■疲労の脳内機序、渡辺恭良、田中雅彰、水野敬、精神医学 Vol.50(6) 特集: 疲労と精神障害 ストレス-疲労-精神障害について、527-532頁、医学書院、2008
■慢性疲労状態の脳機能・分子イメージング、田中雅彰、渡辺恭良、治療 Vol.90(3) 特集: 疲労の診かた、473-479頁、南山堂、2008.
■疲れのメカニズムはどこまでわかったか？、田中雅彰、渡辺恭良、現代化学 Vol.444(3) 特集: 疲労の科学、24-28頁、東京化学同人社、2008.
■乳酸疲労原因物質は誤り！、田中雅彰、渡辺恭良、現代化学 Vol.444(3) 特集: 疲労の科学、29頁、東京化学同人社、2008.
■乳酸は疲労原因物質でないというのは本当か？、田中雅彰、渡辺恭良、Clinical Neuroscience Vol.26(1) 108頁、中外医学社、2008.
■西谷真人,宗清芳美,杉野友啓,梶本修身,新規抗疲労成分：イミダゾールペプチド,日本補完代替医療学会誌,2009;6(3):123-129
■梶本修身,天野浩之,ストレスと眼精疲労 －Fatigue and asthenopia－,眼科,2009;51(4): 397-407.
■梶本修身, 疲労の生化学的バイオマーカー（血液、尿）,医学のあゆみ, 2009; 228(6): 659-663.
■梶本修身,杉野友啓,青柳さやか,抗疲労食品開発プロジェクト, 医学のあゆみ, 2009; 228(6): 722-726.
■梶本修身,抗疲労食薬開発, 治療,2008; 90(3): 503-508.
■梶本修身, 野﨑聡,疲労のバイオマーカー開発と抗疲労食薬の開発,現代化学,2008; 3: 35-37.
■梶本修身, エビデンスに基づくサプリメントの選択と新医療ビジネス, 病院設備,2008;50(2): 145-146.
■梶本修身,慢性疲労症候群(CFS)研究の進歩と診療への手引き 疲労研究における最近の進歩 疲労の定量化,Progress in Medicine,2005;25(5);1327-1332
■梶本修身,疲労の定量化とバイオマーカー,脳21, 2004;7(1);32-35
■梶本修身,疲労の経済学,脳21, 2004;(1);64-67
■梶本修身,疲労の分子神経メカニズム 疲労の定量化と前頭葉機能,自立神経機能,Molecular Medicine, 2004;41(10);1277-1282
■梶本修身,疲労の客観的評価 疲労の定量化法,医学のあゆみ,2003;204(5);377-380
【和文原著】
■CBEX-Dr配合飲料の健常者における抗疲労効果、田中雅彰、鴫原良仁、藤井比佐子、平山佳伸、渡辺恭良、薬理と治療、Vol.36(3) 199-212頁、2008.
【学会誌】
■疲労が生体に及ぼす影響、ならびに胃発がんを助長する可能性について、土井賢一郎、田中雅彰、金光華、渡辺恭良、福島昭治、鰐渕英機、日本疲労学会誌 Vol.2(2) 8-16頁、2007.
